Protein Alignment flz and Tmprss9

DIOPT Version :10

• Sequence 1: NP_001137622.1
• Gene: flz / 35902
• FlyBaseID: FBgn0286782
• Length: 1693
• Species: Drosophila melanogaster
• Sequence 2: XP_006513905.2
• Gene: Tmprss9 / 432478
• MGIID: 3612246
• Length: 1342
• Species: Mus musculus
• Alignment Length: 998
• Identity: 239/998 - (23%)
• Similarity: 341/998 - (34%)
• Gaps: 302/998 - (30%)

  Fly   804 TAVPAPAQRPQYDAVQGDASSERPVLVTASPRP-----RPK--PSTKR---PAVKRPISG----- 853
            |.|...|:.|.|||  ..|..:..||..|.|.|     :|.  |:...   |..|..|||
Mouse   526 TRVLRIAKHPAYDA--DTADFDVAVLELARPLPFGRYVQPACLPAATHVFPPGKKCLISGWGYLK 588

  Fly   854 ESTKKKPQ--PQPSAGAYNQEKISE---HS-TRKPVSNGY--------------DKVPESP---- 894
            |....||:  .:.:....:|...|.   || |.:.|..||              ..|.|.|
Mouse   589 EDFLVKPEVLQKATVELLDQSLCSSLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRF 653

  Fly   895 ---------ITHIQIKKPSATQHKEQEQTGYPRPASPAGYEQTTAAAPAPAAPSLNYDKPDAP-- 948
                     |...:.::|.......:.:.......|.|.......|.||||.||..:  |.:|
Mouse   654 FLAGIVSWGIGCAEARRPGVYTRVTRLRDWILEVTSAADMPVVPTATPAPATPSTPW--PTSPES 716

  Fly   949 --PSQYDQP-SAPSASYDQLAPM-PSLNYNEQHASSPGRKPSTAKPISTSYVTGPSTPRPPATVD 1009
              |:.:.:| :|||.     .|: ||.....|..   |.:|:..||  |..|.|.|...
Mouse   717 WAPNTFAKPTAAPSP-----VPLHPSTTAKPQEC---GARPAMDKP--TRIVGGISAVS------ 765

  Fly  1010 YHYDNVPPLFMADDKLDAFIQSTAENIVGSTPGNYQPPLVATASTPAYAHRPTSSGSYGHKKPGF 1074
               ..||        ..|.::....:..|:|       :|......:.||      .:.|.|...
Mouse   766 ---GEVP--------WQASLKEGPRHFCGAT-------VVGDRWLLSAAH------CFNHTKVEQ 806

  Fly  1075 VQINGTPKPPRPTVLITPKPTAINLVTYSSLSDDSNKLASSTSSYVTGRPGVQGVSSNDFKDPGY 1139
            ||                    .:|.|.|.|                      ||
Mouse   807 VQ--------------------AHLGTVSLL----------------------GV---------- 819

  Fly  1140 FGSSPVHVAFTQSTTEAVYAVPSDDKPAFPGYFGPTPSYPAFSVPGEKVGQNVMEETYTSPNDFV 1204
             |.|||.:...:......|                .|....|.|...::.|.::...|..|   |
Mouse   820 -GGSPVKLGLRRVALHPRY----------------NPGILDFDVALLELAQPLVFNKYIQP---V 864

  Fly  1205 NFP------PVRNPNL-----NMSAASSAVTSDLDLSTPAFVEDVV--------LKDKM--HTLV 1248
            ..|      ||....:     ||...::.....|..::...:|..:        |.|:|  ...:
Mouse   865 CLPLAIHKFPVGRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALYNFSLTDRMLCAGFL 929

  Fly  1249 HKLVASLQGNFEALADMIEEPGSNKTVATYQAGAGGTAKPVRVVTTRKPVRTATTTRPKVTTKKP 1313
            ...|.|.||:........|.||     ..|.||.  .:..:.....:||...|..||.|....|.
Mouse   930 EGRVDSCQGDSGGPLACEETPG-----VFYLAGI--VSWGIGCAQAKKPGVYARITRLKDWILKA 987

  Fly  1314 VTRVTTKAPNKKTSAVSTTTRKPATRRTTVAAKV--TTTTRRPATKKPTRRVSSTVKTTTVSSAR 1376
            ::...:......||:......:|.  :||.|..:  ..||.|.||.:.|.||::....||:|:.
Mouse   988 MSSDPSSMARPHTSSTRLIPSEPP--KTTAAGLIIPEATTSRLATPRATIRVTTRPLNTTLSAR- 1049

  Fly  1377 PADDEIVDEEDEEDVNPNPSDNEIDQGATLSSYGGANGRKIHSTSRTLPTPNLAFHSPSTECGVR 1441
                                 :...:|.|.:.  .|.|..|||            |.|  :||:.
Mouse  1050 ---------------------STTTRGQTAAP--SAPGTTIHS------------HLP--DCGLA 1077

  Fly  1442 PHVKSGRIVGGKGSTFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHCQPGFLASLVA 1506
            |.....|||||..::.|.:||||    |.||.. .:::||.||:..|::::||||
Mouse  1078 PPGALTRIVGGSAASLGEWPWQV----SLWLRR-REHRCGAVLVAERWLLSAAHC---------- 1127

  Fly  1507 VMGEFDISGD------------LESKRSVTKNVKRVIVHRQYDPATFENDLALLELDSPVQFDTH 1559
                |||.||            |.|.....:.|.|:..|..|:..|.:.|:|||||..||:....
Mouse  1128 ----FDIYGDPMQWAAFLGTPFLSSTEGQLERVARIYRHPFYNIYTLDYDVALLELAGPVRRSRL 1188

  Fly  1560 IVPICMPNDVADFTGRMATVTGWGRLKYG----------GGVPSV----------------LQEV 1598
            :.|||:|.......|....:||||.|:.|          |||...                ||:.
Mouse  1189 VRPICLPGPARPPDGARCVITGWGSLREGGIHACVRRSPGGVGDTPHLHLSPDPTGSMARQLQKA 1253

  Fly  1599 QVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSH 1663
            .|.::....|:..:..     :|.:..||||:..|..|||.||:||||..:.|.|::.|.|..|.
Mouse  1254 AVRVLSEQTCRRFYPV-----QISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGQWVLTGVTSW 1313

  Fly  1664 GIKCAAPYLPGVYMRTTFYKPWL 1686
            |..|..|:.||||.|......|:
Mouse  1314 GYGCGRPHFPGVYTRVAAVLGWI 1336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669	64/254 (25%)
		PHA03247	<792..1096	CDD:223021	76/345 (22%)
		Tryp_SPc	1449..1689	CDD:238113	88/276 (32%)
Tmprss9	XP_006513905.2	SEA	285..365	CDD:460188
		LDLa	407..442	CDD:238060
		Tryp_SPc	455..684	CDD:214473	36/159 (23%)
		Tryp_SPc	756..984	CDD:214473	59/336 (18%)
		Tryp_SPc	1085..1336	CDD:238113	87/274 (32%)