DRSC/TRiP Functional Genomics Resources

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Protein Alignment flz and LPA

DIOPT Version :10

Sequence 1:NP_001137622.1 Gene:flz / 35902 FlyBaseID:FBgn0286782 Length:1693 Species:Drosophila melanogaster
Sequence 2:NP_005568.2 Gene:LPA / 4018 HGNCID:6667 Length:2040 Species:Homo sapiens


Alignment Length:2115 Identity:419/2115 - (19%)
Similarity:628/2115 - (29%) Gaps:798/2115 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 PTTSGFRSIET-----------------NGGGRKLFGGY--RITPKHCRATKTL-PSSDPRANG- 108
            ||.:...|:|.                 :|.|:...|.|  .:|.:.|:|..:: |.|..|... 
Human   230 PTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEY 294

  Fly   109 -PTICMFNHECAQRGGEVVGA-------------------CMDGFLFGACCQIPPTHELASTLIN 153
             |...:..:.|  |..:.|.|                   |.|.   ......|||.....:|  
Human   295 YPNAGLIMNYC--RNPDAVAAPYCYTRDPGVRWEYCNLTQCSDA---EGTAVAPPTVTPVPSL-- 352

  Fly   154 EAQNAYFQQHQQQTKLQQSAAQSSFESYGEQQQSLSEEQVAQQPSQNIYDQQNLDKVYQQLDSSS 218
            ||.:      :|....|:...|..:...|:..:......|..:..|                :.|
Human   353 EAPS------EQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQ----------------AWS 395

  Fly   219 SISPPNGAYGDEPQQQEYQSESEQPVRDENA-----YPTSSSSTEATQSQSSSASVEFEQ-EPSQ 277
            |::|              .|.|..|....||     |..:..:..|....:....|.:|. ..:|
Human   396 SMTP--------------HSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQ 446

  Fly   278 PADASNDQTTQKINKQPVQPPNFHVHKHSVT-INSPSSPPQNDDFVMQVLSTLPPEHADDHHIVF 341
            .:||..         ..|.||       :|| :.|..:|.:                        
Human   447 CSDAEG---------TAVAPP-------TVTPVPSLEAPSE------------------------ 471

  Fly   342 TTEVPTKITSGLQDQTSSESNSFEEVSSTPAA---------------TQKPKPKP---------- 381
              :.||:...|:|:.......|:....||...               ::.|:..|          
Human   472 --QAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCR 534

  Fly   382 -----------TQMP---------TQKTTQKATQKPTPKPTQKAKPKPVPQL-AESMKRPIQQKP 425
                       |:.|         ||.:..:.|....|..|      |||.| |.|.:.|.:|:|
Human   535 NPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVT------PVPSLEAPSEQAPTEQRP 593

  Fly   426 --QQV----------------------AKPKPSPKPAQSTNNHHHN-HLIL------DGGEFTHS 459
              |:.                      |....:|.....|..::.| .||:      |.....:.
Human   594 GVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYC 658

  Fly   460 DITHPGADADLVEDLQFSTGYG---------PQPVYAEPPKQ-QQQQQPAEQSYISSSTSAKRPT 514
            ....||...:.....|.|...|         |.|....|.:| ..:|:|..|.....:..:.|.|
Human   659 YTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGT 723

  Fly   515 TGHNSPTTV--------SSITTHVDSIESIILQLNNTSHGPSYNVVSQQTPSYGYPGAAVVQT-- 569
            ..    |||        ||:|.|              ||        .:||.| ||.|.::..  
Human   724 YS----TTVTGRTCQAWSSMTPH--------------SH--------SRTPEY-YPNAGLIMNYC 761

  Fly   570 ------------------------------------------------EPAAQNPTFYQENESEK 586
                                                            .|:.|.||    .:...
Human   762 RNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPT----EQRPG 822

  Fly   587 VQE---SDSQSDYG-YTTTVNYESFYDKVSDEQDASAAVSQSAEMPTARPGYGEDVSAVLEDHTM 647
            |||   .:.||..| |:|||.          .:...|..|.:....:..|.|..:...::.....
Human   823 VQECYHGNGQSYRGTYSTTVT----------GRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRN 877

  Fly   648 P---ANGY------------------HDAE-APVAPQTSEFNKMPVMGIAYPVDMSYMEEEGNLP 690
            |   |..|                  .||| ..|||.|.    .|:..:..|.:.:..|:...:.
Human   878 PDPVAAPYCYTRDPSVRWEYCNLTQCSDAEGTAVAPPTI----TPIPSLEAPSEQAPTEQRPGVQ 938

  Fly   691 ATAAGYGQMSSDSYEAS-TESTYQKLSTVQTEEPQPTYVRPTTNANKQNRPVASYIGMVTMQHY- 753
            ....|.||....:|..: |..|.|..|::              ..:..:|..|.|.....:::| 
Human   939 ECYHGNGQSYQGTYFITVTGRTCQAWSSM--------------TPHSHSRTPAYYPNAGLIKNYC 989

  Fly   754 -NPQP-----------------------GNGDYQAQVPPEV------------SVSSHTTKVQE- 781
             ||.|                       .:.::.|.|||.|            :::..|..||: 
Human   990 RNPDPVAAPWCYTTDPSVRWEYCNLTRCSDAEWTAFVPPNVILAPSLEAFFEQALTEETPGVQDC 1054

  Fly   782 ------------------------------QMDETSNGYQQSETTSGYVSPPTA-------VPAP 809
                                          |...|...|..:..|..|...|.|       ...|
Human  1055 YYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPENYPNAGLTRNYCRNPDAEIRPWCYTMDP 1119

  Fly   810 AQRPQYDAVQGDASSERPVLVTASPRPRPKPSTKRPAVKRPISGESTKKKPQPQPSAGAYNQEKI 874
            :.|.:|..:.....:|..||.|.:  ..|.|||:..:.:.|     |::.|..|.......|...
Human  1120 SVRWEYCNLTQCLVTESSVLATLT--VVPDPSTEASSEEAP-----TEQSPGVQDCYHGDGQSYR 1177

  Fly   875 SEHSTRKPVSNGYDKVPESPITHIQIKK-PSATQHKEQEQTGYPRPASPAGYEQTTAAAPAPAAP 938
            ...||              .:|....:. .|.|.|..|..|.|    .|.|            ..
Human  1178 GSFST--------------TVTGRTCQSWSSMTPHWHQRTTEY----YPNG------------GL 1212

  Fly   939 SLNYDK-PDAPPSQYDQPSAPSA--SYDQLAPMPSLNYNEQHASSPGRKPSTAKPISTSYVTGPS 1000
            :.||.: |||..|.:.....|:.  .|..|...|...             |:....||:......
Human  1213 TRNYCRNPDAEISPWCYTMDPNVRWEYCNLTQCPVTE-------------SSVLATSTAVSEQAP 1264

  Fly  1001 TPRPPATVD-YHYDNVPPLFMADDKLDAFIQSTAENIVGSTPGNYQPPLVATASTPAYAHRPTSS 1064
            |.:.|...| ||.|.           .::..|.:..:.|.|..::      ::.||.:..|.|..
Human  1265 TEQSPTVQDCYHGDG-----------QSYRGSFSTTVTGRTCQSW------SSMTPHWHQRTTEY 1312

  Fly  1065 GSYGHKKPGFVQ---------------------INGTPKP-------PRPTVLITPK-------- 1093
            ...|.....:.:                     .|.|..|       ..|||:..|.        
Human  1313 YPNGGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTVVPVPSTELPSEEA 1377

  Fly  1094 PTAINLVTYSSLSDDSNKLASSTSSYVTGR--------------------PGVQGVSSNDFKDPG 1138
            ||..:.........|......:.|:.:|||                    |.. |::.|..::|.
Human  1378 PTENSTGVQDCYRGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNA-GLTRNYCRNPD 1441

  Fly  1139 -------YFGSSPVHVAF--------TQS---TTEAVYAVPSDDKPAFPG-----------YFGP 1174
                   |.....|...:        |:|   ||..|..|||.:.|:...           |.|.
Human  1442 AEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAPPEKSPVVQDCYHGD 1506

  Fly  1175 TPSYPAFS---VPG--------------EKVGQNV----MEETYTSPND-------FVNFPPVRN 1211
            ..||...|   |.|              ::..:|.    :.|.|....|       :...|.||.
Human  1507 GRSYRGISSTTVTGRTCQSWSSMIPHWHQRTPENYPNAGLTENYCRNPDSGKQPWCYTTDPCVRW 1571

  Fly  1212 PNLNMSAASSAVTSDLDLSTPAFVEDVVLKDKMHTLVHKLVASLQGNFEALADMIEEP------- 1269
            ...|::..|.  |....|.||..|.               |.|::.:.|| |...:.|       
Human  1572 EYCNLTQCSE--TESGVLETPTVVP---------------VPSMEAHSEA-APTEQTPVVRQCYH 1618

  Fly  1270 -------GSNKTVATYQAGAGGTAKPVRVVTTRKPVRTATTTRPKVTTKKPVTRVTTKAPNKKTS 1327
                   |:..|..|     |.|.:....:|..:..||     |:......:|....:.|:..|.
Human  1619 GNGQSYRGTFSTTVT-----GRTCQSWSSMTPHRHQRT-----PENYPNDGLTMNYCRNPDADTG 1673

  Fly  1328 AVSTT------------TRKPATRRTTVA----------------------------AKVTTTTR 1352
            ....|            ||...|..|.||                            .|.||.|.
Human  1674 PWCFTMDPSIRWEYCNLTRCSDTEGTVVAPPTVIQVPSLGPPSEQDCMFGNGKGYRGKKATTVTG 1738

  Fly  1353 RP----ATKKPTRRVSSTVKTTTVSSARPADDEIVDEEDEEDVNPNPSDNEIDQGATLSSYGGAN 1413
            .|    |.::|.|.          |:..|..::....|.....||:               |..|
Human  1739 TPCQEWAAQEPHRH----------STFIPGTNKWAGLEKNYCRNPD---------------GDIN 1778

  Fly  1414 GRKIHSTSRTLPTPNLAFH--------SPSTECG---VRPHVKSGRIVGGKGSTFGAYPWQVLVR 1467
            |...::.:     |...|.        |.|.:||   |.|....|.||||..:...::||||.:|
Human  1779 GPWCYTMN-----PRKLFDYCDIPLCASSSFDCGKPQVEPKKCPGSIVGGCVAHPHSWPWQVSLR 1838

  Fly  1468 ESTWLGLFTKNKCGGVLITSRYVITAAHC-----QPGFLASLVAVMGEFDISGDLESKRSVTKNV 1527
            ..     |.|:.|||.||:..:|:|||||     :|   :|...::|... ..:|||      :|
Human  1839 TR-----FGKHFCGGTLISPEWVLTAAHCLKKSSRP---SSYKVILGAHQ-EVNLES------HV 1888

  Fly  1528 KRVIVHRQYDPATFENDLALLELDSPVQFDTHIVPICMPNDVADFTGRM-ATVTGWGRLK--YGG 1589
            :.:.|.|.:...| :.|:|||:|..|......::|.|:|:.....|.|. ..:||||..:  :|.
Human  1889 QEIEVSRLFLEPT-QADIALLKLSRPAVITDKVMPACLPSPDYMVTARTECYITGWGETQGTFGT 1952

  Fly  1590 GVPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGR 1654
            |   :|:|.|:.:|||.||       .|.|     ::||.:.....|||:||||||||....| :
Human  1953 G---LLKEAQLLVIENEVC-------NHYK-----YICAEHLARGTDSCQGDSGGPLVCFEKD-K 2001

  Fly  1655 YELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRSI 1689
            |.|.|..|.|:.||.|..||||.|.:.:..|:..:
Human  2002 YILQGVTSWGLGCARPNKPGVYARVSRFVTWIEGM 2036

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
flzNP_001137622.1 PRK11633 <365..>439 CDD:236940 23/143 (16%)
PRK10263 <547..>1005 CDD:236669 108/613 (18%)
PHA03247 <792..1096 CDD:223021 66/351 (19%)
Tryp_SPc 1449..1689 CDD:238113 87/247 (35%)
LPANP_005568.2 Kringle 28..105 CDD:395005
Kringle 142..219 CDD:395005
Kringle 256..333 CDD:395005 15/78 (19%)
Kringle 370..447 CDD:395005 15/106 (14%)
Kringle 484..561 CDD:395005 8/76 (11%)
Kringle 598..675 CDD:395005 9/76 (12%)
Kringle 712..789 CDD:395005 17/103 (17%)
Kringle 826..903 CDD:395005 14/86 (16%)
KR 938..1019 CDD:214527 15/94 (16%)
Kringle 1054..1131 CDD:395005 10/76 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1147..1166 6/23 (26%)
KR 1166..1246 CDD:214527 22/109 (20%)
KR 1272..1352 CDD:214527 14/96 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1365..1388 3/22 (14%)
KR 1386..1466 CDD:214527 11/80 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1476..1497 5/20 (25%)
KR 1500..1581 CDD:214527 15/80 (19%)
KR 1614..1695 CDD:214527 15/90 (17%)
Kringle 1720..1799 CDD:395005 18/108 (17%)
Tryp_SPc 1820..2034 CDD:238113 87/245 (36%)
Blue background indicates that the domain is not in the aligned region.

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