DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and TMPRSS11F

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_997290.2	Gene:	TMPRSS11F / 389208	HGNCID:	29994	Length:	438	Species:	Homo sapiens

Alignment Length:	403	Identity:	110/403 - (27%)
Similarity:	173/403 - (42%)	Gaps:	114/403 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1306 PKVTTKKPVTRVTTKA--PNKKTSAVSTTTRKPATRRTTVAAKVTTTTRRPATKKPTRRVSSTVK 1368
            |...:.:.:.:...||  .:.||..:|.|..||:.|.|            |...|..|.:
Human   134 PSTDSAEQIKKKIEKALYQSLKTKQLSLTINKPSFRLT------------PIDSKKMRNL----- 181

  Fly  1369 TTTVSSARPADDEIVDEEDEEDVNPNPSDNEIDQGATLSSYGGANGRKIHSTSRTLPTPNLAFHS 1433
                                                 |:|..|     |..||..:|.|    .|
Human   182 -------------------------------------LNSRCG-----IRMTSSNMPLP----AS 200

  Fly  1434 PSTECGVRPHVKSGRIVGGKGSTF-GAYPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHC- 1496
            .||:          |||.|:.:.. |.:|||..::   .:|  :.::||..||::.:::|||||
Human   201 SSTQ----------RIVQGRETAMEGEWPWQASLQ---LIG--SGHQCGASLISNTWLLTAAHCF 250

  Fly  1497 -----QPGFLASLVAVMGEFDISGDLESKRSVTKNVKRVIVHRQYDPATFENDLALLELDSPVQF 1556
                 ...::|:..|.:          :..:|.:||:::|:|..|...|.|||:||::|.:.|:|
Human   251 WKNKDPTQWIATFGATI----------TPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEF 305

  Fly  1557 DTHIVPICMPNDVADFTGRMAT-VTGWGRLKYGGGVPSVLQEVQVPIIENSVCQEMFHTAGHNKK 1620
            ...:..:|:|:.......:.:. |||:|.:...|.:.:.|::.:|..|...||         |:|
Human   306 SNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVC---------NRK 361

  Fly  1621 ------ILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSHGIKCAAPYLPGVYMRT 1679
                  |....||||:..|:.|:|:||||||||....|..| :.|.||.|..||.|..||||.|.
Human   362 DVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWY-IVGIVSWGQSCALPKKPGVYTRV 425

  Fly  1680 TFYKPWLRSITGV 1692
            |.|:.|:.|.||:
Human   426 TKYRDWIASKTGM 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	81/253 (32%)
TMPRSS11F	NP_997290.2	SEA	59..154	CDD:279699	3/19 (16%)
		Tryp_SPc	205..432	CDD:214473	81/251 (32%)
		Tryp_SPc	206..435	CDD:238113	81/253 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4955
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940