Protein Alignment flz and Corin

DIOPT Version :9

• Sequence 1: NP_001137622.1
• Gene: flz / 35902
• FlyBaseID: FBgn0286782
• Length: 1693
• Species: Drosophila melanogaster
• Sequence 2: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Alignment Length: 1777
• Identity: 362/1777 - (20%)
• Similarity: 564/1777 - (31%)
• Gaps: 697/1777 - (39%)

  Fly   161 QQHQQQTKLQQSAAQSSFESYGEQQQSLSEEQVAQQPSQNIYDQQNLDKVYQQLDSSSSISPPNG 225
            |.||.||                        .||.|.|::            :.:.:||::.|..
  Fly    15 QDHQHQT------------------------SVADQRSRS------------RSERASSLALPLN 43

  Fly   226 AYGD--EPQQQEYQSESEQPVRDENAYPTSSSSTEATQSQSSSASV------------EFEQEPS 276
            :..|  :.||::.:|.:..|:      |::|.|...:.|.|||.|:            |.:|:||
  Fly    44 SLLDFYDKQQEQCKSVTLLPL------PSNSGSISESSSLSSSNSIVRRHSSHYYPMLEDKQKPS 102

  Fly   277 QPADASND----QTTQKINKQPVQPPNF-------HVHKHSVTINSPSSPPQNDDFVMQVLSTLP 330
            |...|:.:    .|.||..:...|..:.       |..:|.|.:::|.:||             |
  Fly   103 QLPQAATEMLVNMTEQKYCQSAHQGASIAGGRQVHHQQQHLVRVDTPVTPP-------------P 154

  Fly   331 PEHADDHHIVFTTEVPTKITSGLQDQTSSESNSFEEVSSTPAATQKPKPKPTQMPTQKTTQKATQ 395
            |             :|.::..|
  Fly   155 P-------------IPRRLLRG------------------------------------------- 163

  Fly   396 KPTPKPTQKAKPKPVPQLAESMKRPIQQKPQQVAKPKPSPKPAQSTNNHHHNHLILDGGEFTHSD 460
                                       :...|.:.|.|.|..|              ||:    |
  Fly   164 ---------------------------KSAWQASSPHPLPLSA--------------GGQ----D 183

  Fly   461 ITHPGADADLVEDLQFSTGYGPQPVYAEPPKQQQQQQPAEQSYISSSTS---------------- 509
            ..|             .||.|...||.:|     :...||.....|...
  Fly   184 GAH-------------GTGTGTVFVYPQP-----ENVTAEAVVRGSGDGQGGGGAGLQSALLVDI 230

  Fly   510 AKRPTTGHNSPTTVSSITTHVDSIESIILQLNNTSHGPSYNVVSQQTPSY---GYPGAAVVQTEP 571
            |.||.:|:.....:|         :...:.|.|:....|......:...|   .|.|.:
  Fly   231 ATRPASGYADADGIS---------DDDRMSLENSVFDESLTSTPVKVAGYLAGRYAGLS------ 280

  Fly   572 AAQNPTFYQENESEKVQESDSQSDYG------------YTTTVNYESFYDKVSDEQDA--SAAVS 622
                   :....:::...|...|.||            .:|:|::.|.:..| |.|.:  ...:|
  Fly   281 -------HMAKRAQRSSSSTVDSAYGSSLGGHSERFASSSTSVDFRSRFSSV-DTQSSLDEKPLS 337

  Fly   623 QSAEMPTA---RPGYGEDVSAVLEDHTMPANGYHDAEAPVAPQTSEFNKMPVMGIAYPVDMSYME 684
            .|.:.|.|   |..|.|  .|||.|.....|                |....:|:|.
  Fly   338 SSIDSPLARDPRDAYRE--RAVLNDAMHKLN----------------NNNTSLGLAL-------- 376

  Fly   685 EEGNLPATAAGYGQMSSDSYEASTESTYQKLSTVQTEEPQPTYVRPTTNANKQNRPVASYIGMVT 749
                               |.||..:..   |:|.::..|    .|...|.||..||..
  Fly   377 -------------------YSASNNNNG---SSVASDGSQ----LPVVPARKQPPPVKG------ 409

  Fly   750 MQHYNPQPGNGDYQAQ---VPPEVSVSSHTTKVQEQMDETSNGYQQSETTSGYVSPPTAVPAPAQ 811
              ..|.....|:.|:|   .|..||.|:.|:..      .|.|  .|..:||.:|..:. |.||.
  Fly   410 --SSNSSNSIGETQSQSSKEPSSVSASASTSSA------ASAG--SSTISSGTMSSMSG-PCPAV 463

  Fly   812 RPQYDAVQGDASSERPVLVTASPRPRPKPSTKRPAVKRPISGESTKKKPQPQPSAGAYNQEKISE 876
            .|..||            :|..|.| |:|..::..|..|:   .|..:..|.|.....|:
  Fly   464 VPPTDA------------ITKRPGP-PEPPLRQANVFDPV---ETGSRGHPPPPLTVRNK----- 507

  Fly   877 HSTRKPVSNGYDKVPESPITHIQIKKPSATQHKEQEQTGYPRPASPAGYEQTTAAAPAPAAPSLN 941
                    .|.:|.|  |||:.::::   .|........|...:|| ||......||...:.. .
  Fly   508 --------LGRNKPP--PITYPRMQQ---RQDSTLSSDSYSISSSP-GYNSKLMEAPLLGSQQ-G 557

  Fly   942 YDKPDAPPSQYDQPSAPSASYDQLAPMPSLNYNEQHASSPGRKPSTAKPISTSYVTGPSTPRPPA 1006
            ..|.:||.|...|           .|:..|        :|.|....|...:.|...||:.|.|.:
  Fly   558 GRKSNAPGSAQRQ-----------TPLMDL--------APTRFLGGAGGGTGSGKQGPAMPPPRS 603

  Fly  1007 TVDYHYDNVPPLFMADDKLDAFIQSTAENIVGSTPGNYQPPLVATASTPAYAHR----------- 1060
            .:::..|:.       ...|:|.|:       |:|| |.|.|:.....|:.:.:
  Fly   604 KINFRQDST-------ISSDSFSQT-------SSPG-YNPKLMEAPLLPSLSAKRLCSAPAPIVC 653

  Fly  1061 -------------PTSSGSYGHK---KPGFVQI-----NGTP-------------KPPRPTVL-- 1089
                         |..:.|..||   :|..:|.     ||.|             |...|.:.
  Fly   654 RQGVQHEPIEELEPPQTISPLHKAAGQPSSLQTIVRFQNGAPHTMSLQHQIINRRKSSNPYITNG 718

  Fly  1090 -ITPKPTAINLVTYSSLSDDSNKLASSTSSYVTGRPGVQGVSSN-----DFKDPGYFGSS----- 1143
             :..:...|.:..::.|:     :|...::|....|.::.|:..     ..:|...||.:
  Fly   719 RLKFRLFQILINAFALLA-----IAGGLAAYFNAYPTIKFVNKTIINTIHVEDTTSFGKNPAPGT 778

  Fly  1144 --PVHVAFTQSTTEAVYAVPSDDKPAFPGYFGPTPSYPAFSVPGEKVGQNVMEETYTSPNDFVNF 1206
              |:.|.|.|.             |..|..:...|:|         :|.....||.|..:.:...
  Fly   779 CLPIIVRFCQG-------------PQIPYNYTVFPNY---------IGHFGQLETQTDLDSYEAL 821

  Fly  1207 PPVR-------------NPNLNMSAASSAVTSDL---------------DLSTPAFV-------- 1235
            ..||             .|....|.|:......|               .||.|.::
  Fly   822 VDVRCYELVSLFLCTLFVPKCGQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDF 886

  Fly  1236 ---EDVV----LKDKMHTLVHKLVASLQ--------------GNFEALADMIEEP---------- 1269
               ||.|    :::.|....|......|              |:.:.: |..:|.
  Fly   887 PSSEDCVGLDEVREVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCM-DQADEAKCERCGPDEI 950

  Fly  1270 --GSNKTVATYQAGAGGTAKP--------VRVVTTRKPVRTATTTRPKVTTK-------KPVTRV 1317
              |.::.:.|.....|....|        :|:......|.|......::..:       |...|.
  Fly   951 YCGDSQCIGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRA 1015

  Fly  1318 TTKAPNKKTSAVSTTTRKPATRRTTVAAKVTTTTRRPATKKPTRRVSSTV-------KTTTVSSA 1375
            .:      .|||.:.....|...|:|   :|..|.||..  .|..||:.:       |:|.:
  Fly  1016 VS------PSAVCSILGYSAVNATSV---LTQLTHRPLL--ATVNVSTDIWKMYAKRKSTLM--- 1066

  Fly  1376 RPADDEIVDEEDEEDVNPNPSDNEIDQGATLSSYGGANGRKIHSTSRTLPTPNLAFHSPSTECG- 1439
                        :|..|...:::......|.|:|                           |||
  Fly  1067 ------------QEFANCKKTEDYPMADLTCSNY---------------------------ECGR 1092

  Fly  1440 VR--PHVKSGRIVGGKGSTFGAYPWQVLVRESTWLG----LFTKNKCGGVLITSRYVITAAHCQP 1498
            |:  .|..|.||:||..::.|.:|:...:     ||    :|   .|.||||:.::|:||:||
  Fly  1093 VKRGRHKPSRRIIGGTQASPGNWPFLAAI-----LGGPEKIF---YCAGVLISDQWVLTASHC-- 1147

  Fly  1499 GFLASLVAVMGEFDISGDLES---KRSVTK-----------NVKRVIVHRQYDPA-TFENDLALL 1548
                     :|.:.:. |||.   :..||:           .||.||.|.||:.| ..:||:||.
  Fly  1148 ---------VGNYSVI-DLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALF 1202

  Fly  1549 ELDSPVQFDTHIVPICM-PNDVADF-TGRMATVTGWGR---------LKYGGGVPSVLQEVQVPI 1602
            :|.:.|.|..|::|:|: |..|.:. .|.:.||.|||:         .:|      ::.||||||
  Fly  1203 QLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEY------IVNEVQVPI 1261

  Fly  1603 IENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRP--DGRYELAGTVSHGI 1665
            |..:.|.|..    .|..:....:|||:.:|.||:|:|||||||:...|  ..|:.:.|.||.||
  Fly  1262 ITRNQCDEWL----DNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGI 1322

  Fly  1666 KCAAPYLPGVYMRTTFYKPWLR 1687
            .||.|.|||||.....|.||::
  Fly  1323 MCAHPRLPGVYANVVQYVPWIQ 1344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862	24/190 (13%)
		PRK11633	<365..>439	CDD:236940	4/73 (5%)
		PRK10263	<547..>1005	CDD:236669	101/480 (21%)
		PHA03247	<792..1096	CDD:223021	72/351 (21%)
		Tryp_SPc	1449..1689	CDD:238113	93/271 (34%)
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	23/137 (17%)
		LDLa	911..942	CDD:238060	4/31 (13%)
		LDLa	945..979	CDD:238060	4/33 (12%)
		SR	980..>1034	CDD:214555	9/59 (15%)
		SRCR	992..1086	CDD:278931	20/119 (17%)
		Tryp_SPc	1103..1343	CDD:214473	93/269 (35%)
		Tryp_SPc	1104..1346	CDD:238113	93/271 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010