DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and HPN

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_001362370.1	Gene:	HPN / 3249	HGNCID:	5155	Length:	417	Species:	Homo sapiens

Alignment Length:	318	Identity:	107/318 - (33%)
Similarity:	148/318 - (46%)	Gaps:	69/318 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1411 GANGR---------KIHSTSRTLPT------PNLAFHSP-STECGVRPHVKSGRIVGGKGSTFGA 1459
            ||||.         ::..|.|.|..      |...|.:. ..:|| |..:...|||||:.::.|.
Human   110 GANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCG-RRKLPVDRIVGGRDTSLGR 173

  Fly  1460 YPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHCQP---------GFLASLVAVMGEFDISG 1515
            :||||.:|..      ..:.|||.|::..:|:|||||.|         ...|..||
Human   174 WPWQVSLRYD------GAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVA--------- 223

  Fly  1516 DLESKRSVTKNVKRVIVHRQY----DPATFE--NDLALLELDSPVQFDTHIVPICMP---NDVAD 1571
             ..|...:...|:.|:.|..|    ||.:.|  ||:||:.|.||:....:|.|:|:|   ..:.|
Human   224 -QASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVD 287

  Fly  1572 FTGRMATVTGWGRLKYGGGVPSVLQEVQVPIIENSVCQEMFHTAG---HNKKILTSFLCAGYANG 1633
              |::.||||||..:|.|....||||.:||||.|.||.      |   :..:|.....||||..|
Human   288 --GKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCN------GADFYGNQIKPKMFCAGYPEG 344

  Fly  1634 QKDSCEGDSGGPLVLQRPDG-----RYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWL 1686
            ..|:|:||||||.|.:  |.     |:.|.|.||.|..||....||||.:.:.::.|:
Human   345 GIDACQGDSGGPFVCE--DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	94/264 (36%)
HPN	NP_001362370.1	Hepsin-SRCR	51..159	CDD:401275	12/49 (24%)
HPN	NP_001362370.1	Tryp_SPc	163..400	CDD:238113	93/262 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910