DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flz and plg

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_958880.2	Gene:	plg / 322691	ZFINID:	ZDB-GENE-030131-1411	Length:	818	Species:	Danio rerio

Alignment Length:	751	Identity:	175/751 - (23%)
Similarity:	268/751 - (35%)	Gaps:	210/751 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1029 IQSTAENIVGSTPGNYQPPLVATASTPAY----AHRPTSSGSYGHKKPG-FVQIN------GTPK 1082
            ||...|..:..:..||:..:..|.|....    :.:|.:.|......|. :::.|      |.|:
Zfish   185 IQDCTEECMQCSGENYRGKISTTVSGFTCQRWDSQQPQNHGYLPSALPDKYLEENYCRNPDGEPR 249

  Fly  1083 P----------------PRPTVLITPKPTAINLVTYSSLSDDSNKLASSTSSYVTGRPGVQGVSS 1131
            |                ||.|   |..||.:..:|.:  |.:.:....:.|..:||:...|..|.
Zfish   250 PWCFTTSPSKRWEACAIPRCT---TEPPTIVPELTCA--SGEGSSYRGTISVTITGKTCQQWTSQ 309

  Fly  1132 NDFK-------------DPGYFGS-----SPVHVAFTQSTTEAVYAVPS------DDKPAFPG-- 1170
            :..|             |..|..:     ||........|.....:|||      .::|..|.
Zfish   310 SPHKHSRSPENYPCKGLDGNYCRNPDNERSPWCYTTDPETRWEYCSVPSCGDQPRPEEPVIPQGE 374

  Fly  1171 --YFGPTPSYPAFSVPGEKVGQNVMEETYTSPNDFVNFPPVRNPNLNMSAASSAVTSDLDLSTPA 1233
              |.|...||           :.||.||.:...  ..|.....|:.:.....:...:||
Zfish   375 ECYEGDGSSY-----------RGVMSETISGKK--CQFWTSMEPHRHSKTPQNFPKADL------ 420

  Fly  1234 FVEDVVLKDKMHTLVHKLVASLQGNFEALADMIEEPGSNKTVATYQAGAGGTAKPVRVVTTRKPV 1298
                                        ..::...|..::....|              ||...|
Zfish   421 ----------------------------RRNLCRNPDGDRAPWCY--------------TTDPTV 443

  Fly  1299 R------TATTTRPKVTTKKPVTRVTTKAPNKKTSAVSTTTRKPAT------------RRTTVAA 1345
            |      .....||.:  ::|..:.....|.:.|.|.||..:...:            |.:|...
Zfish   444 RWEYCNIERCDNRPNI--QEPPAKPAATTPTQSTPAQSTPDQSAPSEKDCKNGNGAEYRGSTSMT 506

  Fly  1346 KVTTTTRRPATKKPTRRVSSTVKTTTVSSARPADDEIVDEEDEEDVNPNPSDNEIDQGATLSSYG 1410
            .:..|.:...:..|.:..|.|.:|      .|      |:..|.:...|| |:::
Zfish   507 VMGVTCQAWRSMTPHQHASFTPET------HP------DKGLESNQCRNP-DSDV---------- 548

  Fly  1411 GANGRKIHSTSRTLPTPNLAF----HSPSTECG---VRPHVKSGRIVGGKGSTFGAYPWQVLVRE 1468
              ||...::|.   |:....:    ...|.:||   .:|....||||||..|...::|||:.:|
Zfish   549 --NGPWCYTTD---PSKKWDYCQIPDCESLKCGQPATKPKRCFGRIVGGCVSKPHSWPWQISLR- 607

  Fly  1469 STWLGLFTKNK---CGGVLITSRYVITAAHC-----QPGFLASLVAVMGEFDISGDLESKRSVTK 1525
                   |:.|   |||.||..::|:|||||     .|.....::.:..| ..:...:.:|.|||
Zfish   608 -------TRGKIHFCGGTLIDPQWVVTAAHCLERSDSPSAYKIMLGIHTE-RATESSKQERDVTK 664

  Fly  1526 NVKRVIVHRQYDPATFENDLALLELDSPVQFDTHIVPICMP-NDVADFTGRMATVTGWGRLKYGG 1589
            .:|        .||  ..|:|||:||.|...:..:.|:|:| .|....:.....|||||..:..|
Zfish   665 IIK--------GPA--GTDIALLKLDRPALINDKVSPVCLPEKDYIVPSNTECYVTGWGETQDTG 719

  Fly  1590 GVPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGR 1654
            | ...|:|...|:|||.||.   ..:..|.::....:|||...|..|||:||||||||.. ....
Zfish   720 G-EGYLKETGFPVIENKVCN---RPSFLNGRVKDHEMCAGNIEGGNDSCQGDSGGPLVCY-AQNT 779

  Fly  1655 YELAGTVSHGIKCAAPYLPGVYMRTTFYKPWL-RSI 1689
            :.|.|..|.|:.||....||||.|.:.:..|: |||
Zfish   780 FVLQGVTSWGLGCANAMKPGVYTRVSKFVDWIERSI 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021	19/93 (20%)
		Tryp_SPc	1449..1689	CDD:238113	86/249 (35%)
plg	NP_958880.2	PAN_AP_HGF	31..104	CDD:238532
		KR	109..190	CDD:214527	2/4 (50%)
		KR	190..270	CDD:214527	14/79 (18%)
		KR	281..361	CDD:214527	16/81 (20%)
		Kringle	376..453	CDD:306546	18/137 (13%)
		KR	490..572	CDD:214527	17/109 (16%)
		Tryp_SPc	589..813	CDD:238113	85/247 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910