DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and Tmprss6

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	261	Identity:	97/261 - (37%)
Similarity:	142/261 - (54%)	Gaps:	26/261 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1437 ECGVRPHVKSGRIVGGKGSTFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHC-QPGF 1500
            :||::.  .|.|||||..|:.|.:|||..      |.:..::.|||.||..|:||||||| |...
  Rat   567 DCGLQG--PSSRIVGGAMSSEGEWPWQAS------LQIRGRHICGGALIADRWVITAAHCFQEDS 623

  Fly  1501 LAS---LVAVMGEFDISGDLESKR---SVTKNVKRVIVHRQYDPATFENDLALLELDSPVQFDTH 1559
            :||   ....:|:.     .::.|   .|:..|.|:.:|..::..:.:.|:|||:||.||.:...
  Rat   624 MASPRLWTVFLGKM-----RQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSAT 683

  Fly  1560 IVPICMPNDVADF-TGRMATVTGWGRLKYGGGVPSVLQEVQVPIIENSVCQEMFHTAGHNKKILT 1623
            :.|:|:|.....| .|:...:||||..:.||...|.||:|.|.:|...:|.|     .:..::..
  Rat   684 VRPVCLPARSHFFEPGQHCWITGWGAQREGGPGSSTLQKVDVQLIPQDLCNE-----AYRYQVTP 743

  Fly  1624 SFLCAGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRS 1688
            ..|||||..|:||:|:||||||||.:.|.||:.|||.||.|:.|..|...|||.|.|....|::.
  Rat   744 RMLCAGYRKGKKDACQGDSGGPLVCKEPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVVNWIQQ 808

  Fly  1689 I 1689
            :
  Rat   809 V 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	93/247 (38%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486
		Tryp_SPc	576..806	CDD:214473	93/245 (38%)
		Tryp_SPc	577..809	CDD:238113	93/247 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910