DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flz and HGF

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_000592.3	Gene:	HGF / 3082	HGNCID:	4893	Length:	728	Species:	Homo sapiens

Alignment Length:	331	Identity:	90/331 - (27%)
Similarity:	135/331 - (40%)	Gaps:	66/331 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1385 EEDEEDVNPNPSDNEIDQGATLSSYGGANGRKIHSTSRTLP-------------TPNLA-FHSPS 1435
            |.|...:|.|...|..|.         |:|...::.:..:|             ||.:. ...|.
Human   429 EPDASKLNENYCRNPDDD---------AHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPV 484

  Fly  1436 TECGVRPHVKSGRIVGG--KGSTFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHCQP 1498
            ..|.   ..|..|:|.|  ..:..|   |.|.:|..      .|:.|||.||...:|:||..|.|
Human   485 ISCA---KTKQLRVVNGIPTRTNIG---WMVSLRYR------NKHICGGSLIKESWVLTARQCFP 537

  Fly  1499 G-FLASLVAVMGEFDISGDLESKRSVTKNVKRVIVHRQYDPATFENDLALLELDSPVQFDTHIVP 1562
            . .|....|.:|..|:.|..:.|.....||.:::    |.|.  .:||.|::|..|...|..:..
Human   538 SRDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLV----YGPE--GSDLVLMKLARPAVLDDFVST 596

  Fly  1563 ICMPN---DVADFTGRMATVTGW---GRLKYGGGVPSVLQEVQVPIIENSVCQEMFHTAGHNKKI 1621
            |.:||   .:.:.|.  .:|.||   |.:.|.|    :|:...:.|:.|..|.:      |::..
Human   597 IDLPNYGCTIPEKTS--CSVYGWGYTGLINYDG----LLRVAHLYIMGNEKCSQ------HHRGK 649

  Fly  1622 LT---SFLCAGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSHGIKCAAPYLPGVYMRTTFYK 1683
            :|   |.:|||........||||.|||||.::...|..| |.:..|..||.|..||:::|..:|.
Human   650 VTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVL-GVIVPGRGCAIPNRPGIFVRVAYYA 713

  Fly  1684 PWLRSI 1689
            .|:..|
Human   714 KWIHKI 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	74/251 (29%)
HGF	NP_000592.3	PAN_APPLE	39..122	CDD:238074
		KR	126..208	CDD:214527
		KR	210..290	CDD:214527
		KR	304..384	CDD:214527
		KR	388..470	CDD:238056	9/49 (18%)
		Tryp_SPc	494..716	CDD:214473	74/249 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000