DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and HABP2

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_004123.1	Gene:	HABP2 / 3026	HGNCID:	4798	Length:	560	Species:	Homo sapiens

Alignment Length:	293	Identity:	98/293 - (33%)
Similarity:	149/293 - (50%)	Gaps:	52/293 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1421 SRTLPTPNL-AFHS-PSTECGVRPHVKSGRIVGGKGSTFGAYPWQVLVRESTWL------GLFTK 1477
            |.|.|:..| .|.| ..||...|   |..||.||..||.|.:|||..::.|..|      |.|
Human   287 SPTEPSTKLPGFDSCGKTEIAER---KIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHF-- 346

  Fly  1478 NKCGGVLITSRYVITAAHCQPGFLASLVAVMGEFDISGDLESKRSVTKNVKRVIVHRQYD----- 1537
              |||.||...:|:|||||.......|..|:|:.|:..:...::|.  .|:::..:..|:
Human   347 --CGGALIHPCWVLTAAHCTDIKTRHLKVVLGDQDLKKEEFHEQSF--RVEKIFKYSHYNERDEI 407

  Fly  1538 PATFENDLALLELDSPVQFDTH-------IVPICMPNDVADFTGRMATVTGWGRLKYGGGVPSVL 1595
            |   .||:|||:| .||  |.|       :..:|:| |.:..:|....::|||..:.|.|...:|
Human   408 P---HNDIALLKL-KPV--DGHCALESKYVKTVCLP-DGSFPSGSECHISGWGVTETGKGSRQLL 465

  Fly  1596 QEVQVPIIENSVC--QEMFHTAGHNKKILTSFLCAGYANGQK---DSCEGDSGGPLVLQRPDGRY 1655
             :.:|.:|.|::|  ::::     :..|..|.:|||  |.||   |:|:|||||||..:: ||.|
Human   466 -DAKVKLIANTLCNSRQLY-----DHMIDDSMICAG--NLQKPGQDTCQGDSGGPLTCEK-DGTY 521

  Fly  1656 ELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRS 1688
            .:.|.||.|::|..  .||||.:.|.:..|:::
Human   522 YVYGIVSWGLECGK--RPGVYTQVTKFLNWIKA 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	87/263 (33%)
HABP2	NP_004123.1	EGF	77..106	CDD:306513
		KR	191..277	CDD:238056
		Tryp_SPc	314..553	CDD:238113	87/263 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910