DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flz and F2

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_075213.2	Gene:	F2 / 29251	RGDID:	61996	Length:	617	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	132/500 - (26%)
Similarity:	199/500 - (39%)	Gaps:	144/500 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1302 TTTRPKVTTKKPVTRVTTKAPNKKTSAVSTTTRKPATRRTTVAAKV------TTTTRRPATKKPT 1360
            :||.|....|:...|    .|:..||.....|..|..||...:..|      ||....|.::...
  Rat   145 STTHPGADLKENFCR----NPDSSTSGPWCYTTDPTVRREECSIPVCGQEGRTTVKMTPRSRGSK 205

  Fly  1361 RRVS------------------------------STVKTTTVSSARPADDEIVDEEDEEDVNPNP 1395
            ..:|                              .::.|.|:|..:..|.|:   :..::...||
  Rat   206 ENLSPPLGECLLERGRLYQGNLAVTTLGSPCLAWDSLPTKTLSKYQNFDPEV---KLVQNFCRNP 267

  Fly  1396 SDNEIDQGA-------------TLSSYGGANGRKIHSTSRTLP--TPNLAFHS---------PST 1436
            ..:|  :||             :|:....|.|.:.|....::.  |.:..||:         ...
  Rat   268 DRDE--EGAWCFVAQQPGFEYCSLNYCDEAVGEENHDGDESIAGRTTDAEFHTFFDERTFGLGEA 330

  Fly  1437 ECGVRP--HVKS---------------GRIVGGKGSTFGAYPWQVLVRESTWLGLFTKNK----C 1480
            :||:||  ..||               ||||.|..:..|..||||:        ||.|:.    |
  Rat   331 DCGLRPLFEKKSLTDKTEKELLDSYIDGRIVEGWDAEKGIAPWQVM--------LFRKSPQELLC 387

  Fly  1481 GGVLITSRYVITAAHC------QPGFLAS-LVAVMGEFDISGDLESKRSVTKNV------KRVIV 1532
            |..||:.|:|:|||||      ...|..: |:..:|:       .|:....:||      :::.:
  Rat   388 GASLISDRWVLTAAHCILYPPWDKNFTENDLLVRIGK-------HSRTRYERNVEKISMLEKIYI 445

  Fly  1533 HRQYD-PATFENDLALLELDSPVQFDTHIVPICMPND-------VADFTGRMATVTGWGRLKYGG 1589
            |.:|: ....:.|:|||:|..||.|..:|.|:|:|:.       .|.:.||   |||||.|:...
  Rat   446 HPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLQAGYKGR---VTGWGNLRETW 507

  Fly  1590 GV------PSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGY-ANGQK--DSCEGDSGGP 1645
            ..      |||||.|.:||:|..||:     |....:|..:..|||: .|..|  |:||||||||
  Rat   508 TTNINEIQPSVLQVVNLPIVERPVCK-----ASTRIRITDNMFCAGFKVNDTKRGDACEGDSGGP 567

  Fly  1646 LVLQRP-DGRYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRSI 1689
            .|::.| :.|:...|.||.|..|......|.|......|.|::.:
  Rat   568 FVMKSPYNHRWYQMGIVSWGEGCDRNGKYGFYTHVFRLKRWMQKV 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	90/274 (33%)
F2	NP_075213.2	GLA	25..89	CDD:214503
		KR	107..189	CDD:214527	13/47 (28%)
		Kringle	215..292	CDD:278480	11/81 (14%)
		Thrombin_light	312..359	CDD:286482	8/46 (17%)
		Tryp_SPc	359..608	CDD:214473	90/271 (33%)
		Tryp_SPc	360..612	CDD:238113	90/274 (33%)
		High affinity receptor-binding region which is also known as the TP508 peptide	547..569		13/21 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000