DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and PRSS50

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_037402.1	Gene:	PRSS50 / 29122	HGNCID:	17910	Length:	385	Species:	Homo sapiens

Alignment Length:	384	Identity:	91/384 - (23%)
Similarity:	147/384 - (38%)	Gaps:	107/384 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1332 TTRKPATRRTTVAAKVTTTTRRPAT--KKPTRRVSSTVKTTTVSSARPADDEIVDEEDEEDVNPN 1394
            :|..||.:......|.|..:.||..  :.||   :.|:.:||:.:..|..:..||
Human    48 STADPADQSVQCVPKATCPSSRPRLLWQTPT---TQTLPSTTMETQFPVSEGKVD---------- 99

  Fly  1395 PSDNEIDQGATLSSYGGANGRKIHSTSRTLPTPNLAFHSPSTECGVR----PHVKSGRIVGGKGS 1455
                                                   |...||..    |.::....|..:
Human   100 ---------------------------------------PYRSCGFSYEQDPTLRDPEAVARR-- 123

  Fly  1456 TFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHCQPGFLASLV--AVMGEFDISGDLE 1518
                :||.|.||.:      ..:.|.|.:|.|::|:|.|||       |:  .|:....:.....
Human   124 ----WPWMVSVRAN------GTHICAGTIIASQWVLTVAHC-------LIWRDVIYSVRVGSPWI 171

  Fly  1519 SKRSVTKN---VKRVIVHRQYDPATF------ENDLALLELDSPVQFDTHIVPICMPNDVADFTG 1574
            .:.:.|.:   |.:||:|.:|....|      .||:.||:|...:::..::.|||:|.  .|:..
Human   172 DQMTQTASDVPVLQVIMHSRYRAQRFWSWVGQANDIGLLKLKQELKYSNYVRPICLPG--TDYVL 234

  Fly  1575 R---MATVTGWGRLKYGGGVPS--VLQEVQVPIIENSVCQEMFHTAGHNKKILT-------SFLC 1627
            :   ..||||||..|..|..|.  .:||.:|.|:.|..|...:|   :..||.|       ..:|
Human   235 KDHSRCTVTGWGLSKADGMWPQFRTIQEKEVIILNNKECDNFYH---NFTKIPTLVQIIKSQMMC 296

  Fly  1628 AGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWL 1686
            |...:.:| .|...:|.|||... :|.:.|.|.||.|..|.....|.:|::.:.|:.|:
Human   297 AEDTHREK-FCYELTGEPLVCSM-EGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWI 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	72/261 (28%)
PRSS50	NP_037402.1	Tryp_SPc	118..353	CDD:238113	71/260 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910