DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and Tmprss11d

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_663536.1	Gene:	Tmprss11d / 231382	MGIID:	2385221	Length:	417	Species:	Mus musculus

Alignment Length:	378	Identity:	113/378 - (29%)
Similarity:	172/378 - (45%)	Gaps:	64/378 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1325 KTSAVSTTTRKPATRRTTVAAKVTTTTRRPATKKPTRRVSST-VKTTTVSSARPADDEIVDEEDE 1388
            |:..:.|...|.....|.|.|.|....|  ::|:..|:|..| :::.....:...:.||....:.
Mouse    94 KSEFIRTHVVKLRKEGTGVVADVVMKFR--SSKRNNRKVMKTRIQSVLRRLSSSGNLEIAPSNEI 156

  Fly  1389 EDVNPNPSDNEIDQGATLSSYGGANGRKIHSTSRTLPTPNLAFHSPSTECGVRPH---VKSGRIV 1450
            ..:....::|.:.|                                  |||.||.   :...||:
Mouse   157 TSLTDQDTENVLTQ----------------------------------ECGARPDLITLSEERII 187

  Fly  1451 GGKGSTFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHC-----QPGFLASLVAVMGE 1510
            ||..:..|.:||||.      |.|...:.|||.||::.:|:|||||     .|.:   ..|..|.
Mouse   188 GGMQAEPGDWPWQVS------LQLNNVHHCGGALISNMWVLTAAHCFKSYPNPQY---WTATFGV 243

  Fly  1511 FDISGDLESKRSVTKNVKRVIVHRQYDPATFENDLALLELDSPVQFDTHIVPICMPNDVAD-FTG 1574
            ..:|..|..:      |:.::.|..|...|.:||:|:::||..|.|..:|..:|:|....: ..|
Mouse   244 STMSPRLRVR------VRAILAHDGYSSVTRDNDIAVVQLDRSVAFSRNIHRVCLPAATQNIIPG 302

  Fly  1575 RMATVTGWGRLKYGGGVPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCE 1639
            .:|.|||||.|.|||...:.|::.:|.||.:..|..   .||::..:|...||||..:|..|:|:
Mouse   303 SVAYVTGWGSLTYGGNAVTNLRQGEVRIISSEECNT---PAGYSGSVLPGMLCAGMRSGAVDACQ 364

  Fly  1640 GDSGGPLVLQRPDGRYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRSITGV 1692
            ||||||||.:.....:.:.|.||.|.:|..|..||||.|.|.|:.|:|..||:
Mouse   365 GDSGGPLVQEDSRRLWFVVGIVSWGYQCGLPNKPGVYTRVTAYRNWIRQQTGI 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	89/245 (36%)
Tmprss11d	NP_663536.1	SEA	48..140	CDD:279699	12/47 (26%)
		Tryp_SPc	185..411	CDD:214473	88/243 (36%)
		Tryp_SPc	186..414	CDD:238113	89/245 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BKY1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810