DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and Habp2

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_001316864.1	Gene:	Habp2 / 226243	MGIID:	1196378	Length:	554	Species:	Mus musculus

Alignment Length:	294	Identity:	102/294 - (34%)
Similarity:	150/294 - (51%)	Gaps:	53/294 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1425 PTPNLAFHSPSTE------CG---VRPH-VKSGRIVGGKGSTFGAYPWQVLVRESTWLGLFTK-- 1477
            |.|..:...|..|      ||   |..| ||  ||.||..||.|.:||||.::.|  |.|.|.
Mouse   276 PNPVESLLEPVMELPGFESCGKTEVAEHAVK--RIYGGFKSTAGKHPWQVSLQTS--LPLTTSMP 336

  Fly  1478 --NKCGGVLITSRYVITAAHCQPGFLASLVAVMGEFDISGDLESKRSVTKNVKRVIVHRQYD--- 1537
              :.|||.||...:|:|||||.......|..|:|:.|:. ..||... |..|::::.:.||:
Mouse   337 QGHFCGGALIHPCWVLTAAHCTDINTKHLKVVLGDQDLK-KTESHEQ-TFRVEKILKYSQYNERD 399

  Fly  1538 --PATFENDLALLELDSPV-----QFDTHIVPICMPNDVADFTGRMATVTGWGRLKYGGGVPSVL 1595
              |   .||:|||:| .||     ....::..:|:|:|... :|....::|||..:.|.|...:|
Mouse   400 EIP---HNDIALLKL-KPVGGHCALESRYVKTVCLPSDPFP-SGTECHISGWGVTETGEGSRQLL 459

  Fly  1596 QEVQVPIIENSVC--QEMF-HTAGHNKKILTSFLCAGYANGQK---DSCEGDSGGPLVLQRPDGR 1654
             :.:|.:|.|.:|  :::: ||      |..|.:|||  |.||   |:|:|||||||..:: ||.
Mouse   460 -DAKVKLIANPLCNSRQLYDHT------IDDSMICAG--NLQKPGSDTCQGDSGGPLTCEK-DGT 514

  Fly  1655 YELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRS 1688
            |.:.|.||.|.:|...  ||||.:.|.:..|:::
Mouse   515 YYVYGIVSWGQECGKK--PGVYTQVTKFLNWIKT 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	91/260 (35%)
Habp2	NP_001316864.1	EGF_CA	67..103	CDD:238011
		EGF_CA	150..182	CDD:238011
		KR	187..271	CDD:238056
		Tryp_SPc	308..547	CDD:238113	91/260 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910