DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and F12

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_000496.2	Gene:	F12 / 2161	HGNCID:	3530	Length:	615	Species:	Homo sapiens

Alignment Length:	306	Identity:	97/306 - (31%)
Similarity:	139/306 - (45%)	Gaps:	47/306 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1416 KIHSTSRTLP--------------TPNLAFHSPSTECG--VRPHVKS-GRIVGGKGSTFGAYPWQ 1463
            |...|:||.|              .|:|..:.| ..||  :|..:.| .|:|||..:..||:|:
Human   324 KPQPTTRTPPQSQTPGALPAKREQPPSLTRNGP-LSCGQRLRKSLSSMTRVVGGLVALRGAHPY- 386

  Fly  1464 VLVRESTWLGLFTKNKCGGVLITSRYVITAAHCQPGFLA--SLVAVMGEFDISGDLESKRSVTKN 1526
              :....|...|    |.|.||...:|:|||||.....|  .|..|:|:...:...|..:::.
Human   387 --IAALYWGHSF----CAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLA-- 443

  Fly  1527 VKRVIVHRQYDPATFENDLALLELD-----SPVQFDTHIVPICMPNDVA---DFTGRMATVTGWG 1583
            |:...:|..:.|.::::|||||.|.     |......::.|:|:|:..|   :.|  :..|.|||
Human   444 VRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETT--LCQVAGWG 506

  Fly  1584 RLKYGGG--VPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPL 1646
            . ::.|.  ..|.|||.|||.:....|..   ...|...||...||||:..|..|:|:|||||||
Human   507 H-QFEGAEEYASFLQEAQVPFLSLERCSA---PDVHGSSILPGMLCAGFLEGGTDACQGDSGGPL 567

  Fly  1647 VL--QRPDGRYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRSIT 1690
            |.  |..:.|..|.|.:|.|..|.....||||....:|..|:|..|
Human   568 VCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHT 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	83/253 (33%)
F12	NP_000496.2	FN2	41..88	CDD:128373
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:278437
		Kringle	217..295	CDD:278480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..359		8/35 (23%)
		Tryp_SPc	372..609	CDD:214473	82/251 (33%)
		Tryp_SPc	373..612	CDD:238113	83/253 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910