DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flz and F10

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	347	Identity:	98/347 - (28%)
Similarity:	151/347 - (43%)	Gaps:	69/347 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1354 PATKKPTRRVSSTVKTTTVSSARPADDEIVDEEDEEDVNP--NPSDNEIDQGATLSSYGGANGRK 1416
            |..|:...|...:|...|.||....|.......|..|::|  ||.| .:|...|....|..|
Human   171 PCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFD-LLDFNQTQPERGDNN--- 231

  Fly  1417 IHSTSRTLPTPNLAFHSPSTECGVRPHVKSGRIVGGKGSTFGAYPWQ-VLVRESTWLGLFTKNKC 1480
                                         ..|||||:....|..||| :|:.|.      .:..|
Human   232 -----------------------------LTRIVGGQECKDGECPWQALLINEE------NEGFC 261

  Fly  1481 GGVLITSRYVITAAHCQPGFLASLVAV-MGEFDISGDLESKRSVTKNVKRVIVHRQYDPATFEND 1544
            ||.:::..|::|||||.  :.|....| :|  |.:.:.|........|:.||.|.::...|::.|
Human   262 GGTILSEFYILTAAHCL--YQAKRFKVRVG--DRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFD 322

  Fly  1545 LALLELDSPVQFDTHIVPICMP-NDVAD---FTGRMATVTGWGRLKYGGGVPSVLQEVQVPIIEN 1605
            :|:|.|.:|:.|..::.|.|:| .|.|:   .|.:...|:|:||....|...:.|:.::||.::.
Human   323 IAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDR 387

  Fly  1606 SVCQEMFHTAGHNKKILTSFL------CAGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSHG 1664
            :.|           |:.:||:      ||||...|:|:|:||||||.|.:..| .|.:.|.||.|
Human   388 NSC-----------KLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKD-TYFVTGIVSWG 440

  Fly  1665 IKCAAPYLPGVYMRTTFYKPWL 1686
            ..||.....|:|.:.|.:..|:
Human   441 EGCARKGKYGIYTKVTAFLKWI 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	79/250 (32%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:317114
		O-glycosylated at one site	183..203		5/19 (26%)
		Tryp_SPc	235..464	CDD:238113	79/250 (32%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910