DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment flz and F7

DIOPT Version :9

Sequence 1:NP_001137622.1 Gene:flz / 35902 FlyBaseID:FBgn0286782 Length:1693 Species:Drosophila melanogaster
Sequence 2:XP_011535776.2 Gene:F7 / 2155 HGNCID:3544 Length:495 Species:Homo sapiens


Alignment Length:369 Identity:119/369 - (32%)
Similarity:163/369 - (44%) Gaps:54/369 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly  1350 TTRRPATKKPTRRVSSTVKTTTVSSARPAD--DEIVDEEDEED-----VNPNPSDNEIDQGATLS 1407
            |...||:   .||:.......:..|..|.|  ..:|....::|     ||.|....:.....|  
Human   136 TQESPAS---WRRLKREASCWSSGSRMPGDLCSALVPSSPDKDDQLICVNENGGCEQYCSDHT-- 195

  Fly  1408 SYGGANGRKIHSTSRTLP-----TPNLAFHSPSTECGVRPHVK-------SGRIVGGKGSTFGAY 1460
              |.....:.|.....|.     ||.:.:     .||..|.::       .|||||||....|..
Human   196 --GTKRSCRCHEGYSLLADGVSCTPTVEY-----PCGKIPILEKRNASKPQGRIVGGKVCPKGEC 253

  Fly  1461 PWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHCQPGF--LASLVAVMGEFDIS---GDLESK 1520
            |||||      |.:.....|||.||.:.:|::||||....  ..:|:||:||.|:|   ||.:|:
Human   254 PWQVL------LLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSR 312

  Fly  1521 RSVTKNVKRVIVHRQYDPATFENDLALLELDSPVQFDTHIVPICMPNDVAD-----FTGRMATVT 1580
            |     |.:||:...|.|.|..:|:|||.|..||....|:||:|:|.....     |. |.:.|:
Human   313 R-----VAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFV-RFSLVS 371

  Fly  1581 GWGRLKYGGGVPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGP 1645
            |||:|...|.....|..:.||.:....|.:.....|.:..|.....||||::|.||||:||||||
Human   372 GWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGP 436

  Fly  1646 LVLQRPDGRYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRSI 1689
            ..... .|.:.|.|.||.|..||.....|||.|.:.|..||:.:
Human   437 HATHY-RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKL 479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
flzNP_001137622.1 PRK14948 <272..452 CDD:237862
PRK11633 <365..>439 CDD:236940
PRK10263 <547..>1005 CDD:236669
PHA03247 <792..1096 CDD:223021
Tryp_SPc 1449..1689 CDD:238113 95/249 (38%)
F7XP_011535776.2 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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