DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flz and Tmprss13

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	XP_006510195.1	Gene:	Tmprss13 / 214531	MGIID:	2682935	Length:	561	Species:	Mus musculus

Alignment Length:	742	Identity:	159/742 - (21%)
Similarity:	245/742 - (33%)	Gaps:	236/742 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   979 SSPGRKPSTAKPISTSYVTGPSTPRPPATVDYHYDNVPPLFMADDKLDAFIQSTAENIVGSTPGN 1043
            |||.|.|..|.|..||          ||..
Mouse     9 SSPARTPPQASPARTS----------PARA----------------------------------- 28

  Fly  1044 YQPPLVATASTPAYAHRPTSSGSYGHKKPGFVQINGTPKPPRPTVLITPKPTAINLVTYSSLSDD 1108
              ||..:.|.||.                   |.:.|..||:.:....|.|.|
Mouse    29 --PPQASPARTPP-------------------QASPTRTPPQASPARAPPPQA------------ 60

  Fly  1109 SNKLASSTSSYVTGRPGVQGVSSNDFKDPGYFGSSPVHVAFTQSTTEAVYAVPSDDKPAFPGYFG 1173
            |...||...:.:...|..:..|..         ||....|.|.|:...||.|.:....|.|....
Mouse    61 SPARASPARASLARAPPSRSSSGR---------SSSARSASTTSSPTRVYLVRATPVGAVPIRAS 116

  Fly  1174 PTPSYPAFSVPGEKVGQNVMEETYTSPNDFVNFPPVRNPNLNMSAASSAVTSDLDLSTPAF---- 1234
            |..|.||.....|..|                                       ||.|.|
Mouse   117 PARSAPATRATRESPG---------------------------------------LSFPKFSWQE 142

  Fly  1235 -------VEDVVLKDKMHTLVHKLVASLQGNFEALADMIEEPGSNKTVATYQAGAGGTAKPVRVV 1292
                   :..|:|   :.:||..|:....|.        |......|...:..|..|       :
Mouse   143 TQRQLPLIGCVIL---LISLVISLILLYGGR--------ETQSPRGTAVYFWRGHTG-------I 189

  Fly  1293 TTRKPVRT----ATTTRPKVTTK--------------KPVTRVTTKAPNKKTSAVSTTTRKPATR 1339
            ..::|:.:    |......|..|              |.:.:|.:.:..:.....|::.....::
Mouse   190 KYKEPLESCPIHAVRCDGVVDCKMKSDELGCVRFDWDKSLLKVYSGSSGEWLPVCSSSWNDTDSK 254

  Fly  1340 RTTVAAKVTTTTRRPATKKPTRRVSSTVKTTTVSSARPADDEIVDEEDEEDVNPNPSDNEIDQGA 1404
            ||.                ......|..:||.|                       :..:|....
Mouse   255 RTC----------------QQLGFDSAYRTTEV-----------------------AHRDITSSF 280

  Fly  1405 TLSSYGGANGRKIHSTSRTLPTPNLAFHS-PSTECGVRPHVKSGRIVGGKGSTFGAYPWQVLVRE 1468
            .||.|.......::.:.    .|:..:.| ..:.||:|  ..:||||||..::...:||||
Mouse   281 LLSEYNTTIQESLYRSQ----CPSRRYVSLQCSHCGLR--AMTGRIVGGALTSESKWPWQV---- 335

  Fly  1469 STWLGLFTKNKCGGVLITSRYVITAAHCQPGFLASLVAVMGEFDISGDLESKRSVTK--NVKRVI 1531
            |...|  |.:.|||.||.:::|:|||||   |..:...::..:.:.....:...:.:  ::.::|
Mouse   336 SLHFG--TTHICGGTLIDAQWVLTAAHC---FFVTREKLLEGWKVYAGTSNLHQLPEAASISQII 395

  Fly  1532 VHRQYDPATFENDLALLELDSPVQFDTHIVPICMPNDVADF-TGRMATVTGWGRLKYGGGVPS-V 1594
            ::..|.....:.|:||:.|..|:....||.|.|:|.....| ......:||:|:.|......| .
Mouse   396 INGNYTDEQDDYDIALIRLSKPLTLSAHIHPACLPMHGQTFGLNETCWITGFGKTKETDEKTSPF 460

  Fly  1595 LQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGRYELAG 1659
            |:||||.:|:...|.:..   .::..:....:|||...|.:|||:||||||||.:: :.|:.|||
Mouse   461 LREVQVNLIDFKKCNDYL---VYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQ-NNRWYLAG 521

  Fly  1660 TVSHGIKCAAPYLPGVYMRTTFYKPWL 1686
            ..|.|..|.....||||.:.|...||:
Mouse   522 VTSWGTGCGQKNKPGVYTKVTEVLPWI 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669	9/25 (36%)
		PHA03247	<792..1096	CDD:223021	22/116 (19%)
		Tryp_SPc	1449..1689	CDD:238113	77/242 (32%)
Tmprss13	XP_006510195.1	PHA03378	<6..>122	CDD:223065	40/199 (20%)
		LDLa	<204..220	CDD:238060	2/15 (13%)
		SRCR_2	225..314	CDD:373897	17/131 (13%)
		Tryp_SPc	319..548	CDD:214473	77/241 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910