Protein Alignment flz and Plg

DIOPT Version :10

• Sequence 1: NP_001137622.1
• Gene: flz / 35902
• FlyBaseID: FBgn0286782
• Length: 1693
• Species: Drosophila melanogaster
• Sequence 2: NP_032903.3
• Gene: Plg / 18815
• MGIID: 97620
• Length: 812
• Species: Mus musculus
• Alignment Length: 812
• Identity: 191/812 - (23%)
• Similarity: 288/812 - (35%)
• Gaps: 218/812 - (26%)

  Fly   955 PSAPSASYDQLAPMPSLNYNEQHASSPGRKPSTAKPISTSYVTGPSTPRPPATVDYHYDNVPP-- 1017
            |..|:.|       ||.:.||....:..|.|...:.....|.|.|..       .|.|.|:|.
Mouse   132 PHVPNYS-------PSTHPNEGLEENYCRNPDNDEQGPWCYTTDPDK-------RYDYCNIPECE 182

  Fly  1018 ---LFMADDKLDAFIQSTAENIVGSTPGNYQPPLVATASTPAYAHRPTSSGSYGHKKPGFVQING 1079
               ::.:.:|.:..|..|...:......:..|        .|:.:.|....|...|.......:|
Mouse   183 EECMYCSGEKYEGKISKTMSGLDCQAWDSQSP--------HAHGYIPAKFPSKNLKMNYCRNPDG 239

  Fly  1080 TPKP----------------PRPTVLITPKPTAINLVTYSSLSDDSNKLASSTSSYVTGRP---- 1124
            .|:|                ||.|   ||.|..  ..||..|.........:.|..|:|:.
Mouse   240 EPRPWCFTTDPTKRWEYCDIPRCT---TPPPPP--SPTYQCLKGRGENYRGTVSVTVSGKTCQRW 299

  Fly  1125 ---------------GVQGVSSNDFKDPGYFGSSPVHVAFTQSTTEAVYA-VPSDDKPAFPGYFG 1173
                           ..:.:..|..::|.  |.:......|.|.....|. :||.:..|
Mouse   300 SEQTPHRHNRTPENFPCKNLEENYCRNPD--GETAPWCYTTDSQLRWEYCEIPSCESSA------ 356

  Fly  1174 PTPSYPAFSVPGEKVGQNVMEETYTSPNDFVNFPPVRNPNLNMSAASS--AVTSDLDLSTPAFVE 1236
             :|.....|||.|: ...|::|.|.|  |..::....:..:......|  |:.......||....
Mouse   357 -SPDQSDSSVPPEE-QTPVVQECYQS--DGQSYRGTSSTTITGKKCQSWAAMFPHRHSKTPENFP 417

  Fly  1237 DVVLKDKMHTLVHKLVASLQGNFEALADMIEEPGSNKTVATYQAGAGGTAKPVRVVTTRKPVRTA 1301
            |               |.|:.|:      ...|..:|....|
Mouse   418 D---------------AGLEMNY------CRNPDGDKGPWCY----------------------- 438

  Fly  1302 TTTRPKV----------------TTKKPVTRVTTKAPNKKTSAVSTTTRKPATRRTTVAAKVTTT 1350
             ||.|.|                ..:.|........|:...:.......|....:|.|.| ..|.
Mouse   439 -TTDPSVRWEYCNLKRCSETGGSVVELPTVSQEPSGPSDSETDCMYGNGKDYRGKTAVTA-AGTP 501

  Fly  1351 TRRPATKKPTRRVSSTVKTTTVSSARPADDEIVDEEDEEDVNPNPSDNEIDQGATLSSYGGANGR 1415
            .:..|.::|.|....|.:|...:..            |::...||.             |..||.
Mouse   502 CQGWAAQEPHRHSIFTPQTNPRAGL------------EKNYCRNPD-------------GDVNGP 541

  Fly  1416 KIHSTSR-------TLPTPNLAFHSPSTECG---VRPHVKSGRIVGGKGSTFGAYPWQVLVREST 1470
            ..::|:.       .:|   |...:.|.|||   |.|....||:|||..:...::|||:.:|..
Mouse   542 WCYTTNPRKLYDYCDIP---LCASASSFECGKPQVEPKKCPGRVVGGCVANPHSWPWQISLRTR- 602

  Fly  1471 WLGLFT-KNKCGGVLITSRYVITAAHC-----QPGFLASLVAVMGEFDISGDLESKRSVTKNVKR 1529
                || ::.|||.||...:|:|||||     :|.|...::....|: |.|....:.||.|.:
Mouse   603 ----FTGQHFCGGTLIAPEWVLTAAHCLEKSSRPEFYKVILGAHEEY-IRGLDVQEISVAKLI-- 660

  Fly  1530 VIVHRQYDPATFENDLALLELDSPVQFDTHIVPICMPND---VADFTGRMATVTGWGRLK--YGG 1589
                  .:|.  ..|:|||:|..|......::|.|:|:.   |||.|  :..:||||..:  :|.
Mouse   661 ------LEPN--NRDIALLKLSRPATITDKVIPACLPSPNYMVADRT--ICYITGWGETQGTFGA 715

  Fly  1590 GVPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGR 1654
            |   .|:|.|:|:|||.||..:.:.   |.::.::.||||...|..|||:||||||||....| :
Mouse   716 G---RLKEAQLPVIENKVCNRVEYL---NNRVKSTELCAGQLAGGVDSCQGDSGGPLVCFEKD-K 773

  Fly  1655 YELAGTVSHGIKCAAPYLPGVYMRTTFYKPWL 1686
            |.|.|..|.|:.||.|..||||:|.:.:..|:
Mouse   774 YILQGVTSWGLGCARPNKPGVYVRVSRFVDWI 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669	12/49 (24%)
		PHA03247	<792..1096	CDD:223021	33/161 (20%)
		Tryp_SPc	1449..1689	CDD:238113	89/249 (36%)
Plg	NP_032903.3	PAN_AP_HGF	<38..97	CDD:238532
		KR	101..183	CDD:214527	16/64 (25%)
		KR	183..262	CDD:214527	12/86 (14%)
		KR	273..354	CDD:214527	13/82 (16%)
		KR	375..456	CDD:214527	19/127 (15%)
		KR	480..562	CDD:214527	19/110 (17%)
		Tryp_SPc	582..807	CDD:238113	89/249 (36%)