DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flz and Plg

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_032903.3	Gene:	Plg / 18815	MGIID:	97620	Length:	812	Species:	Mus musculus

Alignment Length:	812	Identity:	191/812 - (23%)
Similarity:	288/812 - (35%)	Gaps:	218/812 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   955 PSAPSASYDQLAPMPSLNYNEQHASSPGRKPSTAKPISTSYVTGPSTPRPPATVDYHYDNVPP-- 1017
            |..|:.|       ||.:.||....:..|.|...:.....|.|.|..       .|.|.|:|.
Mouse   132 PHVPNYS-------PSTHPNEGLEENYCRNPDNDEQGPWCYTTDPDK-------RYDYCNIPECE 182

  Fly  1018 ---LFMADDKLDAFIQSTAENIVGSTPGNYQPPLVATASTPAYAHRPTSSGSYGHKKPGFVQING 1079
               ::.:.:|.:..|..|...:......:..|        .|:.:.|....|...|.......:|
Mouse   183 EECMYCSGEKYEGKISKTMSGLDCQAWDSQSP--------HAHGYIPAKFPSKNLKMNYCRNPDG 239

  Fly  1080 TPKP----------------PRPTVLITPKPTAINLVTYSSLSDDSNKLASSTSSYVTGRP---- 1124
            .|:|                ||.|   ||.|..  ..||..|.........:.|..|:|:.
Mouse   240 EPRPWCFTTDPTKRWEYCDIPRCT---TPPPPP--SPTYQCLKGRGENYRGTVSVTVSGKTCQRW 299

  Fly  1125 ---------------GVQGVSSNDFKDPGYFGSSPVHVAFTQSTTEAVYA-VPSDDKPAFPGYFG 1173
                           ..:.:..|..::|.  |.:......|.|.....|. :||.:..|
Mouse   300 SEQTPHRHNRTPENFPCKNLEENYCRNPD--GETAPWCYTTDSQLRWEYCEIPSCESSA------ 356

  Fly  1174 PTPSYPAFSVPGEKVGQNVMEETYTSPNDFVNFPPVRNPNLNMSAASS--AVTSDLDLSTPAFVE 1236
             :|.....|||.|: ...|::|.|.|  |..::....:..:......|  |:.......||....
Mouse   357 -SPDQSDSSVPPEE-QTPVVQECYQS--DGQSYRGTSSTTITGKKCQSWAAMFPHRHSKTPENFP 417

  Fly  1237 DVVLKDKMHTLVHKLVASLQGNFEALADMIEEPGSNKTVATYQAGAGGTAKPVRVVTTRKPVRTA 1301
            |               |.|:.|:      ...|..:|....|
Mouse   418 D---------------AGLEMNY------CRNPDGDKGPWCY----------------------- 438

  Fly  1302 TTTRPKV----------------TTKKPVTRVTTKAPNKKTSAVSTTTRKPATRRTTVAAKVTTT 1350
             ||.|.|                ..:.|........|:...:.......|....:|.|.| ..|.
Mouse   439 -TTDPSVRWEYCNLKRCSETGGSVVELPTVSQEPSGPSDSETDCMYGNGKDYRGKTAVTA-AGTP 501

  Fly  1351 TRRPATKKPTRRVSSTVKTTTVSSARPADDEIVDEEDEEDVNPNPSDNEIDQGATLSSYGGANGR 1415
            .:..|.::|.|....|.:|...:..            |::...||.             |..||.
Mouse   502 CQGWAAQEPHRHSIFTPQTNPRAGL------------EKNYCRNPD-------------GDVNGP 541

  Fly  1416 KIHSTSR-------TLPTPNLAFHSPSTECG---VRPHVKSGRIVGGKGSTFGAYPWQVLVREST 1470
            ..::|:.       .:|   |...:.|.|||   |.|....||:|||..:...::|||:.:|..
Mouse   542 WCYTTNPRKLYDYCDIP---LCASASSFECGKPQVEPKKCPGRVVGGCVANPHSWPWQISLRTR- 602

  Fly  1471 WLGLFT-KNKCGGVLITSRYVITAAHC-----QPGFLASLVAVMGEFDISGDLESKRSVTKNVKR 1529
                || ::.|||.||...:|:|||||     :|.|...::....|: |.|....:.||.|.:
Mouse   603 ----FTGQHFCGGTLIAPEWVLTAAHCLEKSSRPEFYKVILGAHEEY-IRGLDVQEISVAKLI-- 660

  Fly  1530 VIVHRQYDPATFENDLALLELDSPVQFDTHIVPICMPND---VADFTGRMATVTGWGRLK--YGG 1589
                  .:|.  ..|:|||:|..|......::|.|:|:.   |||.|  :..:||||..:  :|.
Mouse   661 ------LEPN--NRDIALLKLSRPATITDKVIPACLPSPNYMVADRT--ICYITGWGETQGTFGA 715

  Fly  1590 GVPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGR 1654
            |   .|:|.|:|:|||.||..:.:.   |.::.::.||||...|..|||:||||||||....| :
Mouse   716 G---RLKEAQLPVIENKVCNRVEYL---NNRVKSTELCAGQLAGGVDSCQGDSGGPLVCFEKD-K 773

  Fly  1655 YELAGTVSHGIKCAAPYLPGVYMRTTFYKPWL 1686
            |.|.|..|.|:.||.|..||||:|.:.:..|:
Mouse   774 YILQGVTSWGLGCARPNKPGVYVRVSRFVDWI 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669	12/49 (24%)
		PHA03247	<792..1096	CDD:223021	33/161 (20%)
		Tryp_SPc	1449..1689	CDD:238113	89/249 (36%)
Plg	NP_032903.3	PAN_AP_HGF	<38..97	CDD:238532
		KR	101..183	CDD:214527	16/64 (25%)
		KR	183..262	CDD:214527	12/86 (14%)
		KR	273..354	CDD:214527	13/82 (16%)
		KR	375..456	CDD:214527	19/127 (15%)
		KR	480..562	CDD:214527	19/110 (17%)
		Tryp_SPc	581..805	CDD:214473	89/248 (36%)
		Tryp_SPc	582..807	CDD:238113	89/249 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910