DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flz and Plat

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_032898.2	Gene:	Plat / 18791	MGIID:	97610	Length:	559	Species:	Mus musculus

Alignment Length:	287	Identity:	93/287 - (32%)
Similarity:	144/287 - (50%)	Gaps:	58/287 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1433 SPSTECGVRPHVK-SGRIVGGKGSTFGAYPWQVLVRESTWLGLFTKNK--------CGGVLITSR 1488
            ||.:.||:|.:.: ..||.||..:...::|||.        .:|.|||        ||||||:|.
Mouse   292 SPCSTCGLRQYKRPQFRIKGGLYTDITSHPWQA--------AIFVKNKRSPGERFLCGGVLISSC 348

  Fly  1489 YVITAAHCQPGFLA-----SLVAVMGEF--DISGDLESKRSVTKNVKRVIVHRQYDPATFENDLA 1546
            :|::||||   ||.     .|..|:|..  .:.|:.|.    |..:::.|||.::|..|::||:|
Mouse   349 WVLSAAHC---FLERFPPNHLKVVLGRTYRVVPGEEEQ----TFEIEKYIVHEEFDDDTYDNDIA 406

  Fly  1547 LLELDSP----VQFDTHIVPICMPN---DVADFTGRMATVTGWGRLKYGGGVP---SVLQEVQVP 1601
            ||:|.|.    .|..:.:...|:|:   .:.|:|  ...::|:|  |:....|   ..|:|..|.
Mouse   407 LLQLRSQSKQCAQESSSVGTACLPDPNLQLPDWT--ECELSGYG--KHEASSPFFSDRLKEAHVR 467

  Fly  1602 IIENSVC--QEMFHTAGHNKKILTSFLCAG--YANGQK---DSCEGDSGGPLVLQRPDGRYELAG 1659
            :..:|.|  |.:|     ||.:..:.||||  .:.|.:   |:|:||||||||.. .:.:..|.|
Mouse   468 LYPSSRCTSQHLF-----NKTVTNNMLCAGDTRSGGNQDLHDACQGDSGGPLVCM-INKQMTLTG 526

  Fly  1660 TVSHGIKCAAPYLPGVYMRTTFYKPWL 1686
            .:|.|:.|....:||||.:.|.|..|:
Mouse   527 IISWGLGCGQKDVPGVYTKVTNYLDWI 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	87/270 (32%)
Plat	NP_032898.2	FN1	38..80	CDD:214494
		Important for binding to annexin A2. /evidence=ECO:0000250	39..49
		EGF	83..115	CDD:394967
		Kringle	124..205	CDD:395005
		KR	210..295	CDD:238056	2/2 (100%)
		Tryp_SPc	311..556	CDD:238113	86/268 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910