DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	330	Identity:	102/330 - (30%)
Similarity:	150/330 - (45%)	Gaps:	69/330 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1413 NGRKIHSTSRTLPTPNLAFH--------SPSTECGVRPHVKSG---------------RIVGGKG 1454
            ||.........:|.....|.        .|:.:|..||..:.|               |||||..
Human   509 NGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAV 573

  Fly  1455 STFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHC-QPGFLASLV---AVMGEFDISG 1515
            |:.|.:|||..      |.:..::.|||.||..|:||||||| |...:||.|   ..:|:.
Human   574 SSEGEWPWQAS------LQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKV---- 628

  Fly  1516 DLESKR---SVTKNVKRVIVHRQYDPATFENDLALLELDSPVQFDTHIVPICMPNDVADF-TGRM 1576
             .::.|   .|:..|.|:::|..::..:.:.|:|||:||.||.....:.|:|:|.....| .|..
Human   629 -WQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLH 692

  Fly  1577 ATVTGWGRLKYGG----------------------GVPSVLQEVQVPIIENSVCQEMFHTAGHNK 1619
            ..:||||.|:.|.                      .:.:.||:|.|.:|...:|.|::     ..
Human   693 CWITGWGALREGALRADAVALFYGWRNQGSETCCCPISNALQKVDVQLIPQDLCSEVY-----RY 752

  Fly  1620 KILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSHGIKCAAPYLPGVYMRTTFYKP 1684
            ::....|||||..|:||:|:||||||||.:...||:.|||.||.|:.|..|...|||.|.|....
Human   753 QVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVIS 817

  Fly  1685 WLRSI 1689
            |::.:
Human   818 WIQQV 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	92/269 (34%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060	2/6 (33%)
		Ldl_recept_a	520..557	CDD:278486	7/36 (19%)
		Tryp_SPc	568..822	CDD:238113	92/269 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910