Protein Alignment flz and Corin

DIOPT Version :10

• Sequence 1: NP_001137622.1
• Gene: flz / 35902
• FlyBaseID: FBgn0286782
• Length: 1693
• Species: Drosophila melanogaster
• Sequence 2: XP_061506966.1
• Gene: Corin / 1277217
• VectorBaseID: AGAMI1_007116
• Length: 1432
• Species: Anopheles gambiae
• Alignment Length: 1787
• Identity: 347/1787 - (19%)
• Similarity: 568/1787 - (31%)
• Gaps: 658/1787 - (36%)

  Fly   172 SAAQSSFESYGEQQQSLSEEQVAQQPSQNIYDQQNLDKVYQQLDSSSSISPPNGAYGD--EPQQQ 234
            ||..::..:|||  :||.:::          |::.:.:       :||::.||.:..|  |.:|:
Mosquito    15 SAGDANPFNYGE--RSLLDDR----------DKRGVTR-------ASSLALPNHSLLDLLEQKQK 60

  Fly   235 EYQSESEQPVRDENAYPTSSSSTEATQSQSSSASVEFEQEPSQPADASNDQTTQKINKQPVQPPN 299
            .|          :..:.|.......|:..||.:....|.|..|.....:.:::|.|...|:.||
Mosquito    61 LY----------DTIHLTPPPKGNGTRRHSSDSFPMIENESFQIPQRQSKKSSQGIGPGPLVPP- 114

  Fly   300 FHVHKHSVTINSPSSPPQNDDFVMQVLSTLPPEHADDHHIVFTTEVPTKITSGLQDQTSSESNSF 364
             .|.|.:...|.|..||  |.|.:|..::|
Mosquito   115 -PVPKRTFQGNFPRKPP--DSFEVQKRASL----------------------------------- 141

  Fly   365 EEVSSTPAATQKPKPKPTQMPTQKTTQKATQKPTPKPTQKAKPKPVPQLAESMKRPIQQKPQQVA 429
                             ..:.:.:..|:..|         |:.:.|.||.:.:::.:||:.|| |
Mosquito   142 -----------------LALDSYQQQQQQLQ---------AQQQQVQQLHQQLQQQLQQQHQQ-A 179

  Fly   430 KPK-----------------------PSPKPAQSTNNHHHNHLILDGGEFTHSDITHPGADADLV 471
            :|.                       |:||.|:|............||....|:.|.....|...
Mosquito   180 QPSYAPFGRSERICKSAFEDQTFSYYPAPKSAKSAGVSAGGSASGGGGGGVGSNGTCHSVSATSF 244

  Fly   472 EDL-------QFSTGYGPQPVYAEPPKQQQQQQPAEQSYISSSTSAKRPTTG------------- 516
            :||       .||................:.|...:..|:|::.:.:...||
Mosquito   245 DDLGEPDDFVLFSKKMASIESNRSSSDSNKSQTTIDTGYVSANETDRSLLTGGSCSSAKGGGATS 309

  Fly   517 ----HNSPTTVSSITT-------HVDSIESIILQLNN---------------------------- 542
                .:|..|.||:.:       ..|:|||  |.||:
Mosquito   310 FRSRFSSEDTQSSLDSFLSSELHRTDTIES--LPLNDSPFSLKKNVFNFDLKTSPLIRGSSTVSP 372

  Fly   543 ---------------------------TSHGPSYNVVSQQTPSYGYPGAA-------VVQTEPAA 573
                                       |..||:..:|.|  |....||:|       :....|.:
Mosquito   373 NSIDEKLDSCSPRSIESKGSRKLPTVPTRKGPASGIVMQ--PKLPPPGSASAGPNSRMTPPLPPS 435

  Fly   574 QNPTFYQENESEKVQESDSQ-------SDYGYTTTVNYESFYDK-------------VSDEQDAS 618
            ::...::..:.:|:|::..|       :....|...:.:..|.:             :|.:|..:
Mosquito   436 RSQQAFETRKLQKLQQAQQQQTQLNNVASAHKTALESLQELYSRPLGIRRNIHRPPPLSQQQMVN 500

  Fly   619 AA--------------VSQSAEMPTARPGYGEDV--SAVLEDHTMPANGYHDAEAPVAPQTSEFN 667
            ||              :|..:...|:.||:....  |::|:.||...|            :|:||
Mosquito   501 AAAKASLLGGQRQDSSISSDSFSITSSPGFQSKAMESSLLQQHTSTTN------------SSKFN 553

  Fly   668 KMPVMGIAYPVDMSYMEEEGNLPATAAGYGQMSSDSYEASTESTYQKLSTVQTEEPQPTYVRPTT 732
            :..:.| ..|:|          .|||.|.|         .|......|:.:............|.
Mosquito   554 RSTIRG-KPPMD----------TATAVGIG---------GTNVAPNNLTALMNSAGSTPGASVTA 598

  Fly   733 NANKQNRPVASYIGMVTMQHYNPQPGNG--------DYQAQVPPEVSVSSHTTKVQEQMDETSNG 789
            .:...:....|.|           ||.|        .....|||.||:...::...:...:||:
Mosquito   599 GSTSMSSGTGSTI-----------PGEGLAGIGVSTGTIRSVPPRVSMRQDSSISSDSFSQTSS- 651

  Fly   790 YQQSETTSGYVSPPTAVPAPAQRPQYDAVQGDASSERPVLVTASPRPRPKPSTKRPAVKRPIS-- 852
                                   |.|::    ...|.|:|..|:         |.|.|.:||:
Mosquito   652 -----------------------PSYNS----KIMEAPLLSHAA---------KMPKVSKPIAKN 680

  Fly   853 -GESTKKKPQPQPSAGAYNQEKISEHSTRKPVSNGYDKVPESPITHIQIKKPS--ATQHKEQEQT 914
             .|.||:.|.......|.    |...||           |.|..|.:::...|  :.|||:.:..
Mosquito   681 LDEITKESPTDVNGTAAI----IKSAST-----------PASLQTIVRLSNGSNVSLQHKKFQIL 730

  Fly   915 GYPRPASP------------------------AGYEQTTAAAPAPAAPSLNYDKP----DAPPSQ 951
            ...:.::|                        ||    ..||...|.|::.:...    .|.|:.
Mosquito   731 KARKNSNPYVTSGRLKFRLCQILLNAVGLLAIAG----GLAAYFNAYPTIKFVNQTITRTAVPAS 791

  Fly   952 YDQPSAPSASYDQLAPMPSLNYNEQHASSPGRKPSTAKPISTSYVTGPSTPRPPA---------- 1006
            ....||...| ..::.:|:....:..|.||||   ||..::..: .|...|.|..
Mosquito   792 QPGSSAVGGS-GAVSSVPASGSGQSVAGSPGR---TALDVAGGF-RGDRNPAPGVCLPVIVKFCQ 851

  Fly  1007 --TVDYHYDNVPPLFM-------ADDKLDAFIQSTAENIVGSTPGNYQPPLVATASTPAYAHRPT 1062
              .|.|:| .|.|.::       |..::|.|     |.:|........|..:.:...|
Mosquito   852 QHRVPYNY-TVFPNYIGHFGQPEAQIEIDLF-----EALVDVQCYELVPLFLCSLFVP------- 903

  Fly  1063 SSGSYGHKKPG--------------FVQINGTPKPP--RPTVL---ITPKPTAINLVTYSSLSDD 1108
            ..|:.|...|.              |..:.|...|.  |.::.   ::.:...:.:..|......
Mosquito   904 KCGNSGATVPPCKSLCTETMRRCSFFFDVFGLELPEYLRCSIFNDAVSDQEECVGMAEYKESIIR 968

  Fly  1109 SNKLASSTSSYVTGRPGVQGVSSNDFKDPGYFGSSPVHVAFTQSTTEAVYAVPSDD--------- 1164
            |.:..:.|......|..:    .||:|..|       ||.....|.||......||
Mosquito   969 SRRPMACTGFLCDKRRCI----PNDWKCDG-------HVDCQDQTDEAHCDFCGDDAIHCGEGQC 1022

  Fly  1165 ---KPAFPGYFGPTPSYPAFSVPGEKVGQNVMEETYTSPNDFVNFPPVRNPNLNMSAASSAVTSD 1226
               |....|    ||:.|        .||:.......|.         ||.:|..... ....:|
Mosquito  1023 MSQKHVCDG----TPNCP--------YGQDERNCIRLSE---------RNGDLGRGTL-EVYKAD 1065

  Fly  1227 LDLSTPAFVEDVVLKDKMHTLVHKLVASLQGNFEALADMIEEPGSNKTVATYQAGAGGTAKPVRV 1291
            |....||.|::                             .:|.::.|:.....|
Mosquito  1066 LKQWAPACVKN-----------------------------WDPATSPTMICSLLG---------- 1091

  Fly  1292 VTTRKPVRTATTTRPKVTTKKPVTRVTTKAPNKKTSAVSTTTRKPATRRTTVAAKVTTTTRRPAT 1356
                                             .:|..|:.|....:.||.|:.|..::..|...
Mosquito  1092 ---------------------------------YSSVNSSRTAMRGSNRTLVSTKDASSMWRMYQ 1123

  Fly  1357 KKPTRRVSSTVKTTTVSSARPADDEIVDEEDEEDVNPNPSDNEIDQGATLSSYGGANGRKIHSTS 1421
            ||                    |..::.|.:..|:|......|:    |.|::
Mosquito  1124 KK--------------------DVNLIKEFNSCDINSRYPVAEL----TCSNF------------ 1152

  Fly  1422 RTLPTPNLAFHSPSTECGV---RPHVK-SGRIVGGKGSTFGAYPWQVLVRESTWLG----LFTKN 1478
                           |||.   |.:.| :.|||||..|..|.:|:...:     ||    :|
Mosquito  1153 ---------------ECGKVRNRKYFKATKRIVGGSTSNPGDWPFIAAI-----LGGPEEVF--- 1194

  Fly  1479 KCGGVLITSRYVITAAHC---QPGFLASLVAVMGEFDISGDLESKRSVT-----KNVKRVIVHRQ 1535
            .|.||||..::|:||:||   .|  .:..:..:.::.|...:..:||.|     ..||.||.|..
Mosquito  1195 YCAGVLIADQWVLTASHCIGNSP--TSHTMRNVNDWTIQLGITRRRSHTYYGQKVKVKTVIPHPM 1257

  Fly  1536 YD-PATFENDLALLELDSPVQFDTHIVPICM-PNDVADF-TGRMATVTGWGRLKYGGGVPS---- 1593
            |: ....:||:||.:|.:.|.|..|::|:|: |..:.:. ||...||.|||:.:.....|:
Mosquito  1258 YNLHIPHDNDIALFQLATRVAFHEHLLPVCLPPPHIRELPTGINCTVVGWGKREERNSTPNGASY 1322

  Fly  1594 --VLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPD--GR 1654
              .|.||.|||:...:|.:...|.    .:....:||||..|.:|:|:|||||||:...|:  .|
Mosquito  1323 EPTLNEVNVPIVSRELCIDWLETF----NVTEGMICAGYQEGGRDACQGDSGGPLLCPYPNEKDR 1383

  Fly  1655 YELAGTVSHGIKCAAPYLPGVYMRTTFYKPWL 1686
            :.:.|.||.|::||.|.|||||.....:.||:
Mosquito  1384 WFVGGIVSWGVRCAHPKLPGVYANVPKFIPWI 1415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK11633	<365..>439	CDD:236940	15/96 (16%)
		PRK10263	<547..>1005	CDD:236669	100/541 (18%)
		PHA03247	<792..1096	CDD:223021	68/374 (18%)
		Tryp_SPc	1449..1689	CDD:238113	88/261 (34%)
Corin	XP_061506966.1	None