Protein Alignment flz and ndl

DIOPT Version :10

• Sequence 1: NP_001137622.1
• Gene: flz / 35902
• FlyBaseID: FBgn0286782
• Length: 1693
• Species: Drosophila melanogaster
• Sequence 2: XP_061502719.1
• Gene: ndl / 1269883
• VectorBaseID: AGAMI1_012252
• Length: 2292
• Species: Anopheles gambiae
• Alignment Length: 1613
• Identity: 309/1613 - (19%)
• Similarity: 494/1613 - (30%)
• Gaps: 586/1613 - (36%)

  Fly   238 SESEQPVRDENAYPTSSSSTEATQSQSSS----------------ASVEFEQEPSQPADASNDQT 286
            ::.:|.|.||....|:|:..:.......:                |::.|....:.||.|...|.
Mosquito     2 ADHDQTVLDEELATTNSTRMQQLVGAGRTNWLCLMMTAIGGVIVMAAIAFGFYLTIPASALFQQP 66

  Fly   287 TQKINKQP--VQPPN---------FHVHKHSVTINSPSSPPQNDDFVMQVLSTLPP---EHADDH 337
            :..|..:|  ||.|.         |....|.:.:.|..        ::::|:.|.|   .|....
Mosquito    67 SNLIELEPIEVQSPEELETIRETYFKAEAHDILMGSLE--------LLELLNDLDPLLQRHRSRR 123

  Fly   338 HIVFTTEVPTKITSGLQDQTSSE---------SNSFE------------EVSSTPAATQKPKPKP 381
            .......||.:|:.|  |..|.|         ...|:            ..|.:|.|.:|.:...
Mosquito   124 EAFGAEPVPNRISRG--DDRSGEITYGVRKRVQREFDLGTVPIDYRGILVGSESPRAPRKRRHAD 186

  Fly   382 TQMP----TQKTTQKATQKPTPKPTQKAKPKPVPQLAESMKRPIQQKPQQVAKPKPSPKPAQSTN 442
            ..:.    .:::.||..|:...:..:..|..|..:|.:.:...:|:..::|
Mosquito   187 ISLDDLERAKRSAQKDYQRLEKEYNRCRKEAPNGKLCDQIYEKLQRLSEEV-------------- 237

  Fly   443 NHHHNHLILDGGEFTHSDITHPGADADLVEDLQFSTGYGPQPVYAEPPKQQQQQQPAEQSYISSS 507
                                    :|..:|......|:...    .|.|::...|..|..|.|:.
Mosquito   238 ------------------------NARFLEMANLLQGFSEM----GPAKEKTTPQYEEMYYSSTE 274

  Fly   508 TSAK-RPTTGHNSPTTVSSITTHVDSIESIILQLNNTSHGPSYNVVSQQTPSYGYPGAA---VVQ 568
            .|.. ||..  ::|.....|||    :|.::.::|          ::|..|......:|   ::.
Mosquito   275 RSTSYRPEM--HAPKNDPKITT----VEQLVNKMN----------ITQAIPKEKLRTSAEDEMIT 323

  Fly   569 TEPAAQ--NPTFYQENESEKVQESDSQSDYGYTTTVNYESFYDKVSDEQDASAAVSQSAEMPTAR 631
            |.|...  :|:.::..|:..::..|...|            :.::|.| |||     :.|..|.|
Mosquito   324 TTPMLPVFDPSLHKPIENSSIRSLDDLFD------------HMRLSGE-DAS-----TTEWTTER 370

  Fly   632 PGYGEDVSAVLEDHTMPANGYHDAEAPVAPQTSEFNKMPVMGIAYPVDMSYMEEEGNLPATAAGY 696
                                                                             
Mosquito   371 ----------------------------------------------------------------- 370

  Fly   697 GQMSSDSYEASTESTYQKLSTVQTEEPQPTYVRPTT-----NANKQNRPVASYIGMVTMQHYNPQ 756
                .:.:|...:||....:||: ...|||..|.||     .|.:....|...:.:..|  ..|.
Mosquito   371 ----RELFEFEIDSTSTSPATVK-PSTQPTSKRRTTTKSPLQAARNLHDVVHQLQLAQM--LQPH 428

  Fly   757 PGNGDYQAQVPPEVS--VSSHTTKVQEQMDETSNGYQQSETTSGYVSPPTAVPAPAQRPQYDAVQ 819
            |.:.|.....|..::  |.|.:...:|...:|:            .||..||    ...|:..:|
Mosquito   429 PFHEDLVMSPPENINEFVMSRSRNREEMHHDTT------------PSPMRAV----VHQQHQHLQ 477

  Fly   820 GDASSERP----VLVTASP-----------------RPRPKPSTKRPAVKRPISGESTKKKPQ-- 861
            ..|..:.|    |:..::|                 :|....:|.:.:...||:||:||...|
Mosquito   478 HQAQPQSPHQPLVVGPSAPFLNLCDQLRSAAGNGHLKPTHPGATFQHSPGIPITGEATKASSQII 542

  Fly   862 PQPSAGAYNQEKISEHSTRKPVSNGYDKVPESPITHIQIKKPSATQHKEQEQTGYPRPASPAGYE 926
            ...:.||                 ||  ||.:...:               |...|..|.|..|.
Mosquito   543 VNSAFGA-----------------GY--VPNTVCFY---------------QNAPPVGAQPTAYG 573

  Fly   927 QTTAAAPAPAAPSLNYDKPDAP--PSQYDQPSAPSASYDQLAPMPSLNYNEQHASSPGRKPSTAK 989
            ...|.|.||      |..|:||  |....||      |.|       .::..|..:.|:.|....
Mosquito   574 FRPAGAGAP------YVYPNAPGYPPYQQQP------YHQ-------QHHHHHPGAGGKLPLNDP 619

  Fly   990 PISTSYVTGPSTPR-----PPATVDYHY-----DNVPPLFMADDKLDAFIQSTAENIVGST---- 1040
            .|..  :..|..|.     |.:..:.|:     ..:|    ||......:.|..:|:...|
Mosquito   620 AIDA--LIQPRIPEAMINMPVSIQNLHHAGARTSELP----ADQSGPILLCSMMQNVEQPTRHHA 678

  Fly  1041 -----PGNYQPPLVATASTPAYAHRPTSSGSYG--HKKPGFVQINGTPKPPRPTVLITPKPTAIN 1098
                 |.:.:..|.....|...|.|..::.:.|  |.:.|.|                |..::..
Mosquito   679 GNETHPEDAEEELDENLDTMFAAGRSLAARAKGRHHCRRGSV----------------PCFSSHQ 727

  Fly  1099 LVTYSS-------LSDDSNKLASSTSSYVTGRPGVQGVSS--NDFKDPGYFGSSPVHVAFTQSTT 1154
            .|..||       ..|.|::.|.|..|.:..|....|.:.  ....:.|.||..  ..:|:...|
Mosquito   728 CVKRSSWCDSKTDCMDGSDESACSCVSRLPKRKLCDGYADCPLGMDEMGCFGCE--KFSFSCFHT 790

  Fly  1155 EAVY----------------------AVPSDDKPAFPGYFGPTPSYPAFSVPGEKVGQNVMEETY 1197
            ||.|                      .:...|:............|.|:|||.   ...|:...|
Mosquito   791 EAEYRSAHRSGSMCYSLLEKCDGFDNCLNRKDEQDCTMLVRDLGHYLAYSVPH---STGVLHRNY 852

  Fly  1198 TSPNDFVNFPPVRNPNLNMSAASSAVTSDLDLSTPAFVEDVVLKDKMHTLVHKLVASLQGNFEAL 1262
            ...    .:|...||......|.......||            ::.:.:..|   .||.|.:.:
Mosquito   853 RGK----WYPVCHNPTQWAREACETELGPLD------------REPLLSHGH---GSLPGPYIS- 897

  Fly  1263 ADMIEEPGSNKTVATYQAGAGGTAKPVRVVTTRKPVRTATTTRPKVTTKKPVTRVTTKAPNKKTS 1327
                  ..:|..|:                   :|..:.......|..|.|..|..|...:::.
Mosquito   898 ------QRANSAVS-------------------QPEFSEACNGVYVHVKCPAVRCGTSRMHEQH- 936

  Fly  1328 AVSTTTRKPATRRTTVAAKVTTTTRRPATKKPTRRVSSTVKTTTVSSARPADDEIVDEEDEEDVN 1392
                            ||::...|||.|
Mosquito   937 ----------------AARINVRTRREA------------------------------------- 948

  Fly  1393 PNPSDNEIDQGATLSSYGGANGRKIHSTSRTLPTPNLAFHSPSTECGVRPHVKSGRIVGGKGSTF 1457
               :::||                                           |:|.|||||..:..
Mosquito   949 ---NESEI-------------------------------------------VESVRIVGGSHADP 967

  Fly  1458 GAYPWQVLVRESTWLGLFTKNK--CGGVLITSRYVITAAHCQPGFLASLVAVMGEFDISGDLESK 1520
            .|||:.|        |:|...|  |||.:....::|:||||...|      ....|::...:..|
Mosquito   968 EAYPFIV--------GIFRDGKYHCGGSIYNEHWIISAAHCCDNF------DQHYFEVRSGMLRK 1018

  Fly  1521 RSVTKNVK-----RVIVHRQYDPATFENDLALLELDSPVQFDTHIVPICMP-----NDVADF--- 1572
            ||....|:     .:|||..|..:...||:||:.::.|..::..:.|||||     .|..|:
Mosquito  1019 RSFAPQVQITRVTHMIVHHAYSSSLMANDIALMRVEHPFHYNRWVRPICMPERHRTTDDRDWIWG 1083

  Fly  1573 --TGRMATVTGWGRLKYGGGVPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQK 1635
              .|.:.|..|||.|:..||.|..|.:|.|||:  ..|:       |.....:..:||...:|..
Mosquito  1084 PKAGTVCTAIGWGALRERGGAPDHLMQVSVPIL--GYCK-------HKSDRDSLQICAAEEDGGH 1139

  Fly  1636 DSCEGDSGGPLVLQRPDGRYE--LAGTVSHGIKCAAPYLPGVYMRTTFYKPWL 1686
            |:|:||||||.|.|.....:|  |||.||||..||..:.||||.|...:..|:
Mosquito  1140 DACQGDSGGPFVCQSKSNPFEWYLAGVVSHGEGCARAHEPGVYTRVALFIDWI 1192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK11633	<365..>439	CDD:236940	12/89 (13%)
		PRK10263	<547..>1005	CDD:236669	88/499 (18%)
		PHA03247	<792..1096	CDD:223021	67/349 (19%)
		Tryp_SPc	1449..1689	CDD:238113	86/257 (33%)
ndl	XP_061502719.1	None