Protein Alignment flz and KLK11

DIOPT Version :10

• Sequence 1: NP_001137622.1
• Gene: flz / 35902
• FlyBaseID: FBgn0286782
• Length: 1693
• Species: Drosophila melanogaster
• Sequence 2: XP_011524671.1
• Gene: KLK11 / 11012
• HGNCID: 6359
• Length: 307
• Species: Homo sapiens
• Alignment Length: 285
• Identity: 80/285 - (28%)
• Similarity: 118/285 - (41%)
• Gaps: 76/285 - (26%)

  Fly  1437 ECGVRPHVKSGRIVGGKGSTFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHCQPGFL 1501
            ||  :||               :.|||..:.|.|.|      .||..||..|:::|||||    |
Human    59 EC--KPH---------------SQPWQAALFEKTRL------LCGATLIAPRWLLTAAHC----L 96

  Fly  1502 ASLVAVMGEFDISGDLESKRSVTKNVKRVIVH------------RQYDPAT-------------- 1540
            ...|::.....:|.||.|......::.|.|||            .|...||
Human    97 KPWVSLTSPTHVSPDLSSSNYCLSHLSRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPN 161

  Fly  1541 --FENDLALLELDSPVQFDTHIVPICMPNDVADFTGRMATVTGWG-----RLKYGGGVPSVLQEV 1598
              ..||:.|:::.|||.....:.|:.:.:.... .|....::|||     :|:    :|..|:..
Human   162 KDHRNDIMLVKMASPVSITWAVRPLTLSSRCVT-AGTSCLISGWGSTSSPQLR----LPHTLRCA 221

  Fly  1599 QVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSH 1663
            .:.|||:..|:..:  .|:   |..:.:||....|.||||:||||||||..:     .|.|.:|.
Human   222 NITIIEHQKCENAY--PGN---ITDTMVCASVQEGGKDSCQGDSGGPLVCNQ-----SLQGIISW 276

  Fly  1664 G-IKCAAPYLPGVYMRTTFYKPWLR 1687
            | ..||....||||.:...|..|::
Human   277 GQDPCAITRKPGVYTKVCKYVDWIQ 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	76/273 (28%)
KLK11	XP_011524671.1	Tryp_SPc	53..300	CDD:214473	79/282 (28%)