DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spab and DKK4

DIOPT Version :9

Sequence 1:	NP_610434.1	Gene:	spab / 35901	FlyBaseID:	FBgn0033358	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_055235.1	Gene:	DKK4 / 27121	HGNCID:	2894	Length:	224	Species:	Homo sapiens

Alignment Length:	179	Identity:	41/179 - (22%)
Similarity:	62/179 - (34%)	Gaps:	58/179 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LGLDEYLGPYGAVEQEQHQPHPPPQQMRQQTEVYGIVE--PLIEDTPCADRP-CLLNDD------ 117
            |||.....|.||:..:.:       .:|...:::|..:  ..:.||.|..|. ||...|
Human     7 LGLSWLCSPLGALVLDFN-------NIRSSADLHGARKGSQCLSDTDCNTRKFCLQPRDEKPFCA 64

  Fly   118 --------------CCPSGVCVSTYGEGKCVY------VFGRQRDLCQG-HADCPQGSSCMLVPQ 161
                          |||..:||:..    |..      :..||.|...| ||:...|...    |
Human    65 TCRGLRRRCQRDAMCCPGTLCVNDV----CTTMEDATPILERQLDEQDGTHAEGTTGHPV----Q 121

  Fly   162 EGAWRCEPSVESGGSTSLLEGIFGAKERQPLGSECSSSSDCQVINGMCC 210
            |...:.:||::...         |.|.::  |..|..:.||.  .|:||
Human   122 ENQPKRKPSIKKSQ---------GRKGQE--GESCLRTFDCG--PGLCC 157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spab	NP_610434.1	None
DKK4	NP_055235.1	Dickkopf_N	41..91	CDD:309719	12/53 (23%)
		DKK-type Cys-1	41..90		12/52 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..139		9/42 (21%)
		DKK-type Cys-2	145..218		6/15 (40%)
		Prokineticin	<145..202	CDD:148298	6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1139517at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010