DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and ACVRL1

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_000011.2	Gene:	ACVRL1 / 94	HGNCID:	175	Length:	503	Species:	Homo sapiens

Alignment Length:	476	Identity:	228/476 - (47%)
Similarity:	296/476 - (62%)	Gaps:	59/476 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 PPGRSIWC------NDGLH----------------GGPTARPVGRNGAHACCKDRDFCNR---FL 212
            |..|..||      .:|.|                |.||     ....|.|| |...||.   .:
Human    44 PTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPT-----EFVNHYCC-DSHLCNHNVSLV 102

  Fly   213 WPKTKDQRSDRVEEGRQISVQDYVPHRLTSWEFVAIILG---ATLFICFTGTSTWYYCQRRKRMA 274
            ...|:........:|:                 :|:|||   |.|.:...|....::.:||:...
Human   103 LEATQPPSEQPGTDGQ-----------------LALILGPVLALLALVALGVLGLWHVRRRQEKQ 150

  Fly   275 SGRTFAKEDSAYDPIL----NGNTTIHDIIEM-TTSGSGSAGLPLLVQRSIARQVQLCHVIGKGR 334
            .|......:|:.  ||    .|::.:.|:::. .|:|||| |||.||||::||||.|...:||||
Human   151 RGLHSELGESSL--ILKASEQGDSMLGDLLDSDCTTGSGS-GLPFLVQRTVARQVALVECVGKGR 212

  Fly   335 FGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVT 399
            :||||||.|.||:|||||||||:|.|||||.|||.||:|||:|||||||:|.....:.|||||:|
Human   213 YGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLIT 277

  Fly   400 DYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNL 464
            .|||:|||:|:|....::.:..|.:::|.|.||||||::|.||:|||||||||.||:|:||||||
Human   278 HYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNL 342

  Fly   465 SCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWE 529
            .|.|.||||||.|.:.:|.:||.:..|||||||||||||||.:....|:|||..|::||||:|||
Human   343 QCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWE 407

  Fly   530 IARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECW 594
            ||||..:..|.::|:.|:||||..|||.|:||||||:::..|.||||..|..||..:|::|:|||
Human   408 IARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECW 472

  Fly   595 YPNPVARLTALRIKKTLASIS 615
            ||||.||||||||||||..||
Human   473 YPNPSARLTALRIKKTLQKIS 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	15/65 (23%)
		GS	294..324	CDD:197743	15/30 (50%)
		Pkinase_Tyr	324..611	CDD:285015	177/286 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	177/286 (62%)
ACVRL1	NP_000011.2	Mediates specificity for BMP ligand	73..76		0/2 (0%)
		TGF_beta_GS	173..200	CDD:312125	13/27 (48%)
		STKc_ACVR1_ALK1	196..493	CDD:271044	183/296 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144584
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750