Protein Alignment babo and ACVRL1

DIOPT Version :10

• Sequence 1: NP_476999.1
• Gene: babo / 35900
• FlyBaseID: FBgn0011300
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_000011.2
• Gene: ACVRL1 / 94
• HGNCID: 175
• Length: 503
• Species: Homo sapiens
• Alignment Length: 476
• Identity: 228/476 - (47%)
• Similarity: 296/476 - (62%)
• Gaps: 59/476 - (12%)

  Fly   173 PPGRSIWC------NDGLH----------------GGPTARPVGRNGAHACCKDRDFCNR---FL 212
            |..|..||      .:|.|                |.||     ....|.|| |...||.   .:
Human    44 PTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPT-----EFVNHYCC-DSHLCNHNVSLV 102

  Fly   213 WPKTKDQRSDRVEEGRQISVQDYVPHRLTSWEFVAIILG---ATLFICFTGTSTWYYCQRRKRMA 274
            ...|:........:|:                 :|:|||   |.|.:...|....::.:||:...
Human   103 LEATQPPSEQPGTDGQ-----------------LALILGPVLALLALVALGVLGLWHVRRRQEKQ 150

  Fly   275 SGRTFAKEDSAYDPIL----NGNTTIHDIIEM-TTSGSGSAGLPLLVQRSIARQVQLCHVIGKGR 334
            .|......:|:.  ||    .|::.:.|:::. .|:|||| |||.||||::||||.|...:||||
Human   151 RGLHSELGESSL--ILKASEQGDSMLGDLLDSDCTTGSGS-GLPFLVQRTVARQVALVECVGKGR 212

  Fly   335 FGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVT 399
            :||||||.|.||:|||||||||:|.|||||.|||.||:|||:|||||||:|.....:.|||||:|
Human   213 YGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLIT 277

  Fly   400 DYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNL 464
            .|||:|||:|:|....::.:..|.:::|.|.||||||::|.||:|||||||||.||:|:||||||
Human   278 HYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNL 342

  Fly   465 SCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWE 529
            .|.|.||||||.|.:.:|.:||.:..|||||||||||||||.:....|:|||..|::||||:|||
Human   343 QCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWE 407

  Fly   530 IARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECW 594
            ||||..:..|.::|:.|:||||..|||.|:||||||:::..|.||||..|..||..:|::|:|||
Human   408 IARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECW 472

  Fly   595 YPNPVARLTALRIKKTLASIS 615
            ||||.||||||||||||..||
Human   473 YPNPSARLTALRIKKTLQKIS 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	TFP_LU_ECD_Babo	127..210	CDD:467127	14/58 (24%)
		GS	294..324	CDD:197743	15/30 (50%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	177/286 (62%)
ACVRL1	NP_000011.2	TFP_LU_ECD_ALK1	29..98	CDD:467064	15/59 (25%)
		Mediates specificity for BMP ligand	73..76		0/2 (0%)
		TGF_beta_GS	174..200	CDD:462503	13/26 (50%)
		STKc_ACVR1_ALK1	196..493	CDD:271044	183/296 (62%)