Protein Alignment babo and ACVR2B

DIOPT Version :10

• Sequence 1: NP_476999.1
• Gene: babo / 35900
• FlyBaseID: FBgn0011300
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: XP_005265640.1
• Gene: ACVR2B / 93
• HGNCID: 174
• Length: 533
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 169/554 - (30%)
• Similarity: 264/554 - (47%)
• Gaps: 108/554 - (19%)

  Fly    94 PQDGD--ASGAVAP-------AVTPQLPIYIAQPSAKKPENKIKCHCDTCKESNNICETDG---- 145
            ||.||  |.|...|       |.|.:...|.|....::          |.:.....||.:.
Human    24 PQAGDTRAGGQPLPKGSGRGEAETRECIYYNANWELER----------TNQSGLERCEGEQDKRL 78

  Fly   146 FCFTSVEKNSDGSIIFSYRCLHKSQIFPPGRSIWCND----------GLHGGPTARPVGRNGAHA 200
            .|:.| .:||.|:|          ::...|  .|.:|          .....|.        .:.
Human    79 HCYAS-WRNSSGTI----------ELVKKG--CWLDDFNCYDRQECVATEENPQ--------VYF 122

  Fly   201 CCKDRDFCNRFLWPKTKDQRSDRVEE--GRQISVQ--DYVPHRLTSWEFVAIILGATLFICFTGT 261
            ||.:.:|||         :|...:.|  |.:::.:  ...|..||...:..:.:|....|..  .
Human   123 CCCEGNFCN---------ERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVL--L 176

  Fly   262 STWYYCQRRKRMASGRTFAKEDSAYDPILNGNTTIHDIIEMTTSGSGSAGLPLLVQRSIARQVQL 326
            :.|.|  |.::...|.....||....|                 .|...||         :.:||
Human   177 AFWMY--RHRKPPYGHVDIHEDPGPPP-----------------PSPLVGL---------KPLQL 213

  Fly   327 CHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGT 391
            ..:..:||||.||:.:...:.||||||..:::.||..|.||:.|..::|||:|.||||:.:.:..
Human   214 LEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNL 278

  Fly   392 WTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRG---KPAIAHRDL 453
            ..:|||:|.:|:.|||.|||..:.:..|.:.:::.:::.||::||.|:...||   ||:|||||.
Human   279 EVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDF 343

  Fly   454 KSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTH-RVGTKRYMAPEVLDESMNDQHFDSYKR 517
            ||||:|:||:|:..:.|.|||||........|   || :|||:||||||||:.::|.|. |::.|
Human   344 KSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD---THGQVGTRRYMAPEVLEGAINFQR-DAFLR 404

  Fly   518 ADVYAFGLILWEIARRCNM--GMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHAS 580
            .|:||.||:|||:..||..  |.: |||.||:.:.:...||:||:::||..:|.||.|.:.|...
Human   405 IDMYAMGLVLWELVSRCKAADGPV-DEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKH 468

  Fly   581 DVLHNMAKVMKECWYPNPVARLTALRIKKTLASI 614
            ..|..:...::|||..:..|||:|..:::.::.|
Human   469 PGLAQLCVTIEECWDHDAEARLSAGCVEERVSLI 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	TFP_LU_ECD_Babo	127..210	CDD:467127	17/96 (18%)
		GS	294..324	CDD:197743	3/29 (10%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	120/293 (41%)
ACVR2B	XP_005265640.1	TFP_LU_ECD_ACVR2B	47..137	CDD:467152	22/129 (17%)
		STKc_ACVR2b	215..505	CDD:271042	120/293 (41%)