Protein Alignment babo and ACVR2A

DIOPT Version :10

• Sequence 1: NP_476999.1
• Gene: babo / 35900
• FlyBaseID: FBgn0011300
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001607.1
• Gene: ACVR2A / 92
• HGNCID: 173
• Length: 513
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 169/511 - (33%)
• Similarity: 263/511 - (51%)
• Gaps: 84/511 - (16%)

  Fly   129 CHCDTCKESNNICETDGFCFTSVEKNSDGSIIFSYRCLHKSQIFPPGRSIWCNDGLHGGPTARPV 193
            |:.|..|..:        || :..||..|||          :|...|  .|.:| ::.......|
Human    50 CYGDKDKRRH--------CF-ATWKNISGSI----------EIVKQG--CWLDD-INCYDRTDCV 92

  Fly   194 GRNGA---HACCKDRDFCN-RF-LWPKTKDQRSDRVEEGRQISVQDYVP-HRLTSWEFVAIILGA 252
            .:..:   :.||.:.:.|| :| .:|:.:      |.:.....|....| :.:..:..|.::|.|
Human    93 EKKDSPEVYFCCCEGNMCNEKFSYFPEME------VTQPTSNPVTPKPPYYNILLYSLVPLMLIA 151

  Fly   253 TLFICFTGTSTWYYCQRRKRMASGRTFAKEDSAYDPILNGNTTIHDIIEMTTSGSG-SAGLPLLV 316
            .:.||    :.|.|  |..:|           ||.|:|           :.|...| ....|||.
Human   152 GIVIC----AFWVY--RHHKM-----------AYPPVL-----------VPTQDPGPPPPSPLLG 188

  Fly   317 QRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGF 381
                .:.:||..|..:||||.||:.:...|.||||||..:::.||..|.|:|....::|||||.|
Human   189 ----LKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQF 249

  Fly   382 IAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRG-- 444
            |.|:.:.......|||:|.:||.|||.|:|..:.|..|.:.:::.::|.|||:||.||.|.:.
Human   250 IGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGH 314

  Fly   445 KPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTH-RVGTKRYMAPEVLDESMN 508
            ||||:|||:||||:|:|:||:..|.|.|||::......:.|   || :|||:||||||||:.::|
Human   315 KPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD---THGQVGTRRYMAPEVLEGAIN 376

  Fly   509 DQHFDSYKRADVYAFGLILWEIARRCNM--GMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRP 571
            .|. |::.|.|:||.||:|||:|.||..  |.: |||.||:.:.:...||:|:|::||..:|.||
Human   377 FQR-DAFLRIDMYAMGLVLWELASRCTAADGPV-DEYMLPFEEEIGQHPSLEDMQEVVVHKKKRP 439

  Fly   572 NIPNRWHASDVLHNMAKVMKECWYPNPVARLTA-------LRIKKTLASISVEDKV 620
            .:.:.|.....:..:.:.::|||..:..|||:|       .::::....|:.||.|
Human   440 VLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIV 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	TFP_LU_ECD_Babo	127..210	CDD:467127	19/84 (23%)
		GS	294..324	CDD:197743	5/30 (17%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	121/298 (41%)
ACVR2A	NP_001607.1	TFP_LU_ECD_ACVR2A	25..119	CDD:467151	20/90 (22%)
		STKc_ACVR2a	196..485	CDD:271043	121/293 (41%)