DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and ACVR1B

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_064733.3	Gene:	ACVR1B / 91	HGNCID:	172	Length:	546	Species:	Homo sapiens

Alignment Length:	583	Identity:	283/583 - (48%)
Similarity:	355/583 - (60%)	Gaps:	99/583 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 ASGAVAPAVTPQLPIYIAQPSAKKPE--NKIKCHCDTCKESNNICETDGFCFTSVEKNSDGSIIF 161
            |..|.|.:..|.:.:.:|......|.  ..:.|.|.:|.::|..|||||.|..|: .|.||....
Human     2 AESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSI-FNLDGMEHH 65

  Fly   162 SYRCLHKSQIFPPGRSIWC--NDGLHGGPTARPVGRNGAHACCKDRDFCNRFLWPKTKDQR--SD 222
            ...|:.|.::.|.|:..:|  ::.|          || .|.|.  .|:|||.      |.|  |.
Human    66 VRTCIPKVELVPAGKPFYCLSSEDL----------RN-THCCY--TDYCNRI------DLRVPSG 111

  Fly   223 RVEEGRQISVQDYVPHRLTSW---EFVAIILGAT---------LFICFTGTSTWYYCQRRKRMAS 275
            .::|          |...:.|   |.|.||.|..         :|:........|:.::|..|
Human   112 HLKE----------PEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDM-- 164

  Fly   276 GRTFAKEDSAYDPILNGNTTIHDII-EMTTSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVW 339
                  ||.:.:..|:.:.|:.|:: :::|||||| ||||.|||::||.:.|..:||||||||||
Human   165 ------EDPSCEMCLSKDKTLQDLVYDLSTSGSGS-GLPLFVQRTVARTIVLQEIIGKGRFGEVW 222

  Fly   340 RGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNK----------------- 387
            ||||||.:|||||||||||.||||||||||||||||||||||||||||
Human   223 RGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKADCSFLTLPWEVVMVSA 287

  Fly   388 ------------------------DNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSI 428
                                    :||||||||||:||||:|||||||..:.|....|:.::||.
Human   288 APKLRSLRLQYKGGRGRARFLFPLNNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSA 352

  Fly   429 ATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVG 493
            |:|||||||:||||:|||.||||||||||||||.|..|||.||||||||....|::||....|||
Human   353 ASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVG 417

  Fly   494 TKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIE 558
            ||||||||||||::|.:||||:|.||:||.||:.||||||||.|.:::||||||||:|..|||||
Human   418 TKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIE 482

  Fly   559 EMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVEDKVK 621
            ||:||||.:|.||||||.|.:.:.|..|.|:|:||||.|..||||||||||||:.:||::.||
Human   483 EMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVK 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	28/88 (32%)
		GS	294..324	CDD:197743	17/30 (57%)
		Pkinase_Tyr	324..611	CDD:285015	208/327 (64%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	209/327 (64%)
ACVR1B	NP_064733.3	Activin_recp	32..105	CDD:307282	28/92 (30%)
		TGF_beta_GS	178..205	CDD:312125	15/27 (56%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..539	CDD:271045	209/327 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144592
Domainoid	1	1.000	447	1.000	Domainoid score	I523
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1191
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm40988
orthoMCL	1	0.900	-	-		OOG6_103647
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760