Protein Alignment babo and ACVR1B

DIOPT Version :10

• Sequence 1: NP_476999.1
• Gene: babo / 35900
• FlyBaseID: FBgn0011300
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_064733.3
• Gene: ACVR1B / 91
• HGNCID: 172
• Length: 546
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 283/583 - (48%)
• Similarity: 355/583 - (60%)
• Gaps: 99/583 - (16%)

  Fly    99 ASGAVAPAVTPQLPIYIAQPSAKKPE--NKIKCHCDTCKESNNICETDGFCFTSVEKNSDGSIIF 161
            |..|.|.:..|.:.:.:|......|.  ..:.|.|.:|.::|..|||||.|..|: .|.||....
Human     2 AESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSI-FNLDGMEHH 65

  Fly   162 SYRCLHKSQIFPPGRSIWC--NDGLHGGPTARPVGRNGAHACCKDRDFCNRFLWPKTKDQR--SD 222
            ...|:.|.::.|.|:..:|  ::.|          || .|.|.  .|:|||.      |.|  |.
Human    66 VRTCIPKVELVPAGKPFYCLSSEDL----------RN-THCCY--TDYCNRI------DLRVPSG 111

  Fly   223 RVEEGRQISVQDYVPHRLTSW---EFVAIILGAT---------LFICFTGTSTWYYCQRRKRMAS 275
            .::|          |...:.|   |.|.||.|..         :|:........|:.::|..|
Human   112 HLKE----------PEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDM-- 164

  Fly   276 GRTFAKEDSAYDPILNGNTTIHDII-EMTTSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVW 339
                  ||.:.:..|:.:.|:.|:: :::|||||| ||||.|||::||.:.|..:||||||||||
Human   165 ------EDPSCEMCLSKDKTLQDLVYDLSTSGSGS-GLPLFVQRTVARTIVLQEIIGKGRFGEVW 222

  Fly   340 RGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNK----------------- 387
            ||||||.:|||||||||||.||||||||||||||||||||||||||||
Human   223 RGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKADCSFLTLPWEVVMVSA 287

  Fly   388 ------------------------DNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSI 428
                                    :||||||||||:||||:|||||||..:.|....|:.::||.
Human   288 APKLRSLRLQYKGGRGRARFLFPLNNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSA 352

  Fly   429 ATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVG 493
            |:|||||||:||||:|||.||||||||||||||.|..|||.||||||||....|::||....|||
Human   353 ASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVG 417

  Fly   494 TKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIE 558
            ||||||||||||::|.:||||:|.||:||.||:.||||||||.|.:::||||||||:|..|||||
Human   418 TKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIE 482

  Fly   559 EMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVEDKVK 621
            ||:||||.:|.||||||.|.:.:.|..|.|:|:||||.|..||||||||||||:.:||::.||
Human   483 EMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVK 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	TFP_LU_ECD_Babo	127..210	CDD:467127	26/84 (31%)
		GS	294..324	CDD:197743	17/30 (57%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	209/327 (64%)
ACVR1B	NP_064733.3	TFP_LU_ECD_ALK4	30..102	CDD:467066	25/85 (29%)
		GS	177..207	CDD:197743	17/30 (57%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..539	CDD:271045	209/327 (64%)