DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and Bmpr1a

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_110476.1	Gene:	Bmpr1a / 81507	RGDID:	70989	Length:	532	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	246/523 - (47%)
Similarity:	329/523 - (62%)	Gaps:	55/523 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 KKPENKI-----------KCHCD-TCKES--NNICETDGFCFTSVEKNSDGSIIFSYRCLHKSQI 171
            |||||.:           ||:|. .|.:.  ||.|.|:|.||..:|::..|....:..|:...
  Rat    42 KKPENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLTSGCMKYE-- 104

  Fly   172 FPPGRSIWCNDGLHGGPTA---RPVGRNGAHACCKDRDFCNRFLWPKTKDQRSDRVEEG--RQIS 231
               |....|.|    .|.|   |.:      .||: .:.||::|.|...........:|  |.::
  Rat   105 ---GSDFQCKD----SPKAQLRRTI------ECCR-TNLCNQYLQPTLPPVVIGPFFDGSVRWLA 155

  Fly   232 VQDYVPHRLTSWE--FVAIILGATLFICFTGTSTWYYCQRRKRMASGRTFAKEDSAYDPILNGNT 294
            |       |.|..  .||:|:.::.| |:.     :||:............::|.|:.|:   ..
  Rat   156 V-------LISMAVCIVAMIVFSSCF-CYK-----HYCKSISSRGRYNRDLEQDEAFIPV---GE 204

  Fly   295 TIHDIIEMT-TSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREE 358
            ::.|:|:.: :||||| ||||||||:||:|:|:...:||||:||||.|:||||.||||:|.:.||
  Rat   205 SLKDLIDQSQSSGSGS-GLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEE 268

  Fly   359 CSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLN 423
            .|||||.||||||::||||||||||||.|..|:||||:|:|||||||||:|:|....:||..:|.
  Rat   269 ASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLK 333

  Fly   424 MSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPS 488
            ::.|.|.||.|||.:|.||:||||||||||||||||:|.|.||.|.||||||:.....:.||||.
  Rat   334 LAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDIPL 398

  Fly   489 THRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQP 553
            ..||||:|||||||||||::..||..|..||:|:||||:||:||||..|.|.:|||||||::|..
  Rat   399 NTRVGTRRYMAPEVLDESLSKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPS 463

  Fly   554 DPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVED 618
            |||.|:|::|||:::.||.:.|||::.:.|..:.|:|.|||..||.:||||||||||||.:....
  Rat   464 DPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQ 528

  Fly   619 KVK 621
            .||
  Rat   529 DVK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	25/103 (24%)
		GS	294..324	CDD:197743	17/30 (57%)
		Pkinase_Tyr	324..611	CDD:285015	177/286 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	179/286 (63%)
Bmpr1a	NP_110476.1	Activin_recp	59..138	CDD:279413	26/94 (28%)
		Mediates specificity for BMP ligand. /evidence=ECO:0000250	107..109		0/1 (0%)
		S_TKc	235..519	CDD:214567	175/283 (62%)
		STKc_BMPR1a	238..524	CDD:271122	179/285 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920