DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and Acvr1

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_017447543.1	Gene:	Acvr1 / 79558	RGDID:	620200	Length:	528	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	248/526 - (47%)
Similarity:	330/526 - (62%)	Gaps:	60/526 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 PSAKKPENKIK-----CHCD--TCKESNNICETDGFCFTSVEKNSDGSIIFSYRCLHKSQIFPPG 175
            ||....|.|:.     |.|:  :|...:: ||... ||:|:..| ||..::...|.   |::..|
  Rat    38 PSTLDEEPKVNPKLYMCVCEGLSCGNEDH-CEGQQ-CFSSLSVN-DGFRVYQKGCF---QVYEQG 96

  Fly   176 RSIWCNDGLHGGPTARPVGRNGAHACCKDRDFCNRFLWPK--TKDQ-----RSDRVEEGRQISVQ 233
            : :.|.         .|.....|..||:. |:|||.:..:  ||.:     ::..:|.|..|
  Rat    97 K-MTCK---------TPPSPGQAVECCQG-DWCNRNVTARLPTKGKSFPGSQNFHLEVGLII--- 147

  Fly   234 DYVPHRLTSWEFVAIILGATLFICFTGTSTWYYCQRRKRMASGRTFAKEDSAYDPILN------G 292
                        ::::....||.|..|.:...:.:|.:...:.|     |..|..|..      |
  Rat   148 ------------LSVVFAVCLFACILGVALRKFKRRNQERLNPR-----DVEYGTIEGLITTNVG 195

  Fly   293 NTTIHDIIEMT-TSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSR 356
            ::|:.::::.: |||||| |||.||||::|||:.|...:||||:||||||.|:||||||||||||
  Rat   196 DSTLAELLDHSCTSGSGS-GLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR 259

  Fly   357 EECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTM 421
            :|.|||||.|:|.||||||||||||||:|.....:.|||||:|.|||.|||:|||....:||.:.
  Rat   260 DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSC 324

  Fly   422 LNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDI 486
            |.:.||||:||||||::|.||:||.|||||||||||||||.|..|.|.||||||.|.:..:.:|:
  Rat   325 LRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDV 389

  Fly   487 PSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVV 551
            .:..|||||||||||||||::....||||||.|::||||:|||:|||.....|.::|:.|:||||
  Rat   390 GNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVV 454

  Fly   552 QPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISV 616
            ..|||.|:|:||||:::.||||||||.:...|.::||:||||||.||.||||||||||||..|..
  Rat   455 PNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDN 519

  Fly   617 E-DKVK 621
            . ||:|
  Rat   520 SLDKLK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	23/93 (25%)
		GS	294..324	CDD:197743	16/30 (53%)
		Pkinase_Tyr	324..611	CDD:285015	183/286 (64%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	184/286 (64%)
Acvr1	XP_017447543.1	Activin_recp	56..121	CDD:395845	21/81 (26%)
		TGF_beta_GS	198..225	CDD:400699	14/27 (52%)
		STKc_ACVR1_ALK1	221..518	CDD:271044	189/296 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338296
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850