DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and bmpr1a

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_012822321.2	Gene:	bmpr1a / 734017	XenbaseID:	XB-GENE-485616	Length:	527	Species:	Xenopus tropicalis

Alignment Length:	522	Identity:	248/522 - (47%)
Similarity:	323/522 - (61%)	Gaps:	56/522 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 KKPENKIK-----------CHCD-TCKES--NNICETDGFCFTSVEKNSDGSIIFSYRCLHKSQI 171
            ||.||.:.           |:|. .|.|:  ||.|.|:|.||..:|::..|.||.:..|:...
Frog    40 KKQENGVTLAPEDTLPFLYCYCSGYCPENAVNNTCITNGQCFAMIEEDDHGDIILTSGCMKME-- 102

  Fly   172 FPPGRSIWCNDGLHGGPTARPVGRNGAHACCKDRDFCNRFLWPKTKDQRSDRVEEGRQISVQDYV 236
               |....|.|      :.:.:.|.... ||: .|||||.|.|....:..| .|.|.:
Frog   103 ---GSDFQCKD------SPKALSRRTIE-CCR-TDFCNRDLQPTLSPKLPD-AEYGLR------- 148

  Fly   237 PHRLTSWEFVAIILGATLFICFTGTS-----TWYYCQR--RKRMASGRTFAKEDSAYDPILNGNT 294
                    |:|:|:  :|.:|....:     .|.|..:  .:||...|....:| |:.|......
Frog   149 --------FIALII--SLVVCVIIIAGFILIIWLYKHKLHSQRMLYNRNLDPDD-AFIPAGESLK 202

  Fly   295 TIHDIIEMTTSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREEC 359
            .:.||.:  :||||| ||||||||:||:|:|:...|||||:||||.|:||||.||||:|.:.||.
Frog   203 ALIDISQ--SSGSGS-GLPLLVQRTIAKQIQMVRQIGKGRYGEVWMGKWRGEKVAVKVFFTAEEA 264

  Fly   360 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNM 424
            |||||.||||||::||||||||||||.|..|:|||::|:|:|||||||:|:|....:||.::|.:
Frog   265 SWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQMYLITEYHENGSLYDFLKCTTLDTRSLLKL 329

  Fly   425 SLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPST 489
            :.|.|.||.|||.:|.||:||||||||||||||||:|.|.:|.|.||||||:.......||||..
Frog   330 AYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKENWTCCIADLGLAVKFNSDTHEVDIPLN 394

  Fly   490 HRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPD 554
            .||||||||||||||||:|..||.:|..||:|:|.||:||:.|||..|.|.:||||||||:|..|
Frog   395 TRVGTKRYMAPEVLDESLNKNHFQAYIMADIYSFSLIIWEMTRRCITGGIVEEYQLPYYDMVPND 459

  Fly   555 PSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVEDK 619
            ||.|:|:.|||::..||.:.|||::.:.|..:.|:|.|||..||.:||||||||||||.:.....
Frog   460 PSFEDMRDVVCMKCLRPTVSNRWNSDECLRAVLKLMAECWAQNPASRLTALRIKKTLAKMVESQD 524

  Fly   620 VK 621
            ||
Frog   525 VK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	28/100 (28%)
		GS	294..324	CDD:197743	17/29 (59%)
		Pkinase_Tyr	324..611	CDD:285015	176/286 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	178/286 (62%)
bmpr1a	XP_012822321.2	Activin_recp	57..132	CDD:366445	27/87 (31%)
bmpr1a	XP_012822321.2	STKc_BMPR1a	233..519	CDD:271122	178/285 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010