DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and acvr1b

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001039062.1	Gene:	acvr1b / 733849	XenbaseID:	XB-GENE-483904	Length:	497	Species:	Xenopus tropicalis

Alignment Length:	503	Identity:	268/503 - (53%)
Similarity:	339/503 - (67%)	Gaps:	38/503 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 KIKCHCDTCKESNNICETDGFCFTSVEKNSDGSIIFSYRCLHKSQIFPPGRSIWC--NDGLHGGP 188
            ::||.|..|.:||..|.|||.|..|: .|..|.......|:....:.|||:..:|  ::.:
Frog    25 ELKCMCSNCIQSNFTCVTDGACMVSI-SNVKGKEYHLRACIGHEDLVPPGKPFYCLSSEDI---- 84

  Fly   189 TARPVGRNGAHACCKDRDFCNRFLWPKTKDQRSDRVEEGRQISVQDYVPHRLTSW---EFVAIIL 250
                  || .|.|..  |:||             :::.|  :.....:....:.|   |.||:|.
Frog    85 ------RN-THCCYS--DYCN-------------KIDLG--VPTGQIIVDTPSGWGPVELVAVIA 125

  Fly   251 GATLFIC-FTGTSTWYYCQRRKRMASGRTFAKEDSAYDPILNGNTTIHDII-EMTTSGSGSAGLP 313
            .....|| .......::|.:|. ..:.:....||.:.:..|..:.|:.|:: :::|||||| |||
Frog   126 IPVFLICVILIVVVLFHCHQRV-YHNRQRLDLEDPSCEMYLAKDKTLPDLVYDLSTSGSGS-GLP 188

  Fly   314 LLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENI 378
            |.|||::||.:.|..:||||||||||||:|||.:|||||||||||.|||||||||||||||||||
Frog   189 LFVQRTVARTIVLQEIIGKGRFGEVWRGKWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENI 253

  Fly   379 LGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTR 443
            ||||||||||||||||||||:||||:|||||||..:.|....|:.:|||.|:|||||||:||||:
Frog   254 LGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLSLSAASGLAHLHMEIVGTQ 318

  Fly   444 GKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDESMN 508
            |||.||||||||||||||.|..|||.||||||||....|::||....|||||||||||||||::|
Frog   319 GKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDSATDTIDIAPNQRVGTKRYMAPEVLDETIN 383

  Fly   509 DQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNI 573
            .:||||:|.||:||.||:.|||||||:.|..::|||||:||:|..|||||||:||||.:|.||||
Frog   384 MKHFDSFKCADIYALGLVYWEIARRCSAGGFHEEYQLPFYDLVPSDPSIEEMRKVVCDQKLRPNI 448

  Fly   574 PNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVEDKVK 621
            ||.|.:.:.|..|.|:|:||||.|..||||||||||||:.:|:::.||
Frog   449 PNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSIQEDVK 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	26/88 (30%)
		GS	294..324	CDD:197743	17/30 (57%)
		Pkinase_Tyr	324..611	CDD:285015	207/286 (72%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	208/286 (73%)
acvr1b	NP_001039062.1	Activin_recp	26..98	CDD:366445	26/98 (27%)
		TGF_beta_GS	170..197	CDD:369918	15/27 (56%)
		STKc_TGFbR1_ACVR1b_ACVR1c	203..490	CDD:271045	208/286 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	450	1.000	Domainoid score	I511
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	537	1.000	Inparanoid score	I1169
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm48184
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060