Protein Alignment babo and TGFBR1

DIOPT Version :10

• Sequence 1: NP_476999.1
• Gene: babo / 35900
• FlyBaseID: FBgn0011300
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001293139.1
• Gene: TGFBR1 / 7046
• HGNCID: 11772
• Length: 507
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 289/538 - (53%)
• Similarity: 359/538 - (66%)
• Gaps: 54/538 - (10%)

  Fly    86 ASAVSMLLPQDGDASGAVAPAVTPQLPIYIAQPSAKKPENKIKCHCDTCKESNNICETDGFCFTS 150
            |:|.:.|||      ||.|                      ::|.|..|.:.|..|.|||.||.|
Human    21 AAAAAALLP------GATA----------------------LQCFCHLCTKDNFTCVTDGLCFVS 57

  Fly   151 VEKNSDGSIIFSYRCLHKSQIFPPGRSIWCNDGLHGGPTARPVGRNGAHACCKDRDFCNRFLWPK 215
            |.:.:| .:|.:..|:.:..:.|..|...|      .|::: .|......|| ::|.||:...|.
Human    58 VTETTD-KVIHNSMCIAEIDLIPRDRPFVC------APSSK-TGSVTTTYCC-NQDHCNKIELPT 113

  Fly   216 TKDQRSDRVEEGRQISVQDYVPHRLTSWEFVAIILGATLFICFTGTSTWYYCQRRKRMASGRTFA 280
            |           ...||:.  ...|...|..|:|.|...|:|.:.....|.|..| .:...|...
Human   114 T-----------GPFSVKS--SPGLGPVELAAVIAGPVCFVCISLMLMVYICHNR-TVIHHRVPN 164

  Fly   281 KEDSAYD-PILNGNTTIHDII-EMTTSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRW 343
            :||.:.| |.::..||:.|:| :|||||||| ||||||||:|||.:.|...||||||||||||:|
Human   165 EEDPSLDRPFISEGTTLKDLIYDMTTSGSGS-GLPLLVQRTIARTIVLQESIGKGRFGEVWRGKW 228

  Fly   344 RGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLF 408
            |||.|||||||||||.|||||||||||||||||||||||||||||||||||||||:||||:||||
Human   229 RGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLF 293

  Fly   409 DYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGL 473
            |||..:.|....|:.::||.|:|||||||:||||:||||||||||||||||||.|.:|.|.||||
Human   294 DYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGL 358

  Fly   474 AVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGM 538
            ||||....|::||...|||||||||||||||:|:|.:||:|:||||:||.||:.|||||||::|.
Human   359 AVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGG 423

  Fly   539 IYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLT 603
            |:::|||||||:|..|||:|||:||||.:|.||||||||.:.:.|..|||:|:||||.|..||||
Human   424 IHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLT 488

  Fly   604 ALRIKKTLASISVEDKVK 621
            ||||||||:.:|.::.:|
Human   489 ALRIKKTLSQLSQQEGIK 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	TFP_LU_ECD_Babo	127..210	CDD:467127	24/82 (29%)
		GS	294..324	CDD:197743	23/30 (77%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	211/286 (74%)
TGFBR1	NP_001293139.1	TFP_LU_ECD_ALK5	35..108	CDD:467067	24/81 (30%)
		TGF_beta_GS	180..207	CDD:462503	20/27 (74%)
		STKc_TGFbR1_ACVR1b_ACVR1c	213..500	CDD:271045	211/286 (74%)