DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment babo and tgfbr1a

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001032772.2	Gene:	tgfbr1a / 560578	ZFINID:	ZDB-GENE-051120-75	Length:	500	Species:	Danio rerio

Alignment Length:	496	Identity:	278/496 - (56%)
Similarity:	344/496 - (69%)	Gaps:	33/496 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 CHCDTCKESNNICETDGFCFTSVEKNSDGSIIFSYRCLHKSQIFPPGRSIWCNDGLHGGPTARPV 193
            |:|:.|  .|..|.|.|.||..:.|:|..::....:|:.:..::|..|...|      .|:
Zfish    34 CYCERC--VNRSCNTTGLCFAVIAKSSGQTVTQERQCIQQDDLYPRDRPFQC------APS---- 86

  Fly   194 GRNGAHACCKDRDFCNRFLWPKTKDQRSDRVEEGRQISVQDYVPHRLTSWEFVAI-ILGATLFIC 257
             .||.|..|.:...||:.  ||.       :.|..:...|...|..|.:...|.| :|...|.:.
Zfish    87 -NNGKHPYCCNTHMCNKN--PKV-------IPELPEAEPQSMSPIALAAMIAVPICVLSFVLVLL 141

  Fly   258 FTGTSTWYYCQRRKRMASGRTFAKEDSAYD-PILNGNTTIHDII-EMTTSGSGSAGLPLLVQRSI 320
            |      |.|..|. :...|..::||...| |.|...||:.|:| :|||||||| ||||||||:|
Zfish   142 F------YMCHNRS-IIHHRVPSEEDPTMDHPFLADGTTLKDLIYDMTTSGSGS-GLPLLVQRTI 198

  Fly   321 ARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAAD 385
            ||.:.|...|||||||||||||||||.|||||||||||.||||||||||||||||||||||||||
Zfish   199 ARTIILQESIGKGRFGEVWRGRWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAAD 263

  Fly   386 NKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAH 450
            |||||||||||||:||||:|||||||..:.|....|:.:|||.|:|||||||:||||:|||||||
Zfish   264 NKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQGKPAIAH 328

  Fly   451 RDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSY 515
            |||||||||||.|.:|.|.||||||||....|::||...|||||||||||||||:|:|.:||:|:
Zfish   329 RDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMRHFESF 393

  Fly   516 KRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHAS 580
            ||||:||.||:.|||||||::|.|:::|||||||:|..|||:|:||:|||.:|.||||||||.:.
Zfish   394 KRADIYALGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEDMKRVVCDQKLRPNIPNRWQSC 458

  Fly   581 DVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVEDKVK 621
            :.|..|||:|:||||.|..|||||||:||:|:.:|.::.:|
Zfish   459 EALRVMAKIMRECWYANGGARLTALRVKKSLSQLSQQEGIK 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	22/84 (26%)
		GS	294..324	CDD:197743	23/30 (77%)
		Pkinase_Tyr	324..611	CDD:285015	210/286 (73%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	210/286 (73%)
tgfbr1a	NP_001032772.2	Activin_recp	32..103	CDD:279413	22/81 (27%)
		TGF_beta_GS	173..200	CDD:285687	20/27 (74%)
		Pkinase_Tyr	202..472	CDD:285015	197/269 (73%)
		STKc_TGFbR1_ACVR1b_ACVR1c	206..493	CDD:271045	210/286 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	448	1.000	Domainoid score	I495
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3177
Inparanoid	1	1.050	543	1.000	Inparanoid score	I1132
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm25848
orthoMCL	1	0.900	-	-		OOG6_103647
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17284
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.860