DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and acvr1

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001017357.1	Gene:	acvr1 / 550111	XenbaseID:	XB-GENE-478850	Length:	512	Species:	Xenopus tropicalis

Alignment Length:	535	Identity:	253/535 - (47%)
Similarity:	336/535 - (62%)	Gaps:	55/535 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 LPIYI----AQPSAKKPENKI-----KCHCD--TCKESNNICETDGFCFTSVEKNSDGSIIFSYR 164
            |||.:    :.||.:..|.|:     ||.|:  :|...::.....  ||.|: .|:||.::....
Frog     8 LPILMMVAFSSPSMEDEEMKLNAGQYKCVCEGMSCGSGDHCYGQQ--CFASL-SNNDGVLVSQKG 69

  Fly   165 CLHKSQIFPPGRSIWCNDGLHGGPTARPVGRNGAHACCKDRDFCNRFLWPKTKDQRSDRVEEGRQ 229
            |.   |::..|: :.|.         .|..::.|..||:. |.||..:..|..| .:.|.::|
Frog    70 CF---QVYEQGK-MTCK---------TPPSQDQAVECCQS-DLCNMNITVKITD-LTGRTKQG-- 117

  Fly   230 ISVQDYVPHRLTSW----EFVAIILGATLFICFTGTSTWYYCQRRKRMASGRTFAKEDSAYDPIL 290
             ...:|....||.:    ..|.::|.....:.|....     ||..:|.|.|     |:.|..|.
Frog   118 -EAPNYSVETLTIFILAPVIVLVVLSVLAVLIFRKIQ-----QRHMQMLSNR-----DAEYGTID 171

  Fly   291 N------GNTTIHDIIEMT-TSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENV 348
            .      |::|:.::::.: |||||| |||.||||::|||:.|...:||||:||||||.|:||:|
Frog   172 GLIASNVGDSTLAEMLDHSCTSGSGS-GLPFLVQRTVARQITLAECVGKGRYGEVWRGLWQGESV 235

  Fly   349 AVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTT 413
            ||||||||:|.|||||.|:|.||:|||||||||||:|.....:.|||||:|.|||.|||:|||..
Frog   236 AVKIFSSRDEKSWFRETELYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHELGSLYDYLQV 300

  Fly   414 HPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHV 478
            ..:|:.|.|.:.||||:||||||::|.||:|||||:||||||||:|||.|..|.|.||||||.|.
Frog   301 TTLDSVTCLRIVLSIASGLAHLHVEIFGTQGKPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHS 365

  Fly   479 EKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEY 543
            :..:.:|:.:..|||||||||||||||::....||||||.|:|||||:|||:|||.....|.:||
Frog   366 QTTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIYAFGLVLWEVARRMVSNGIVEEY 430

  Fly   544 QLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIK 608
            :.|:||||..|||.|:||||||:::.||||||||.:...|..:||:||||||.||.|||||||||
Frog   431 KPPFYDVVPNDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTALAKLMKECWYQNPSARLTALRIK 495

  Fly   609 KTLASISVE-DKVKN 622
            |||..|... ||:|:
Frog   496 KTLTKIDNSLDKLKS 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	21/93 (23%)
		GS	294..324	CDD:197743	16/30 (53%)
		Pkinase_Tyr	324..611	CDD:285015	183/286 (64%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	184/286 (64%)
acvr1	NP_001017357.1	Activin_recp	33..104	CDD:279413	21/87 (24%)
		TGF_beta_GS	182..209	CDD:285687	14/27 (52%)
		STKc_ACVR1_ALK1	205..502	CDD:271044	189/296 (64%)
		S_TKc	215..496	CDD:214567	180/280 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010