DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and Bmpr1b

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_006233462.1	Gene:	Bmpr1b / 310914	RGDID:	1595863	Length:	502	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	258/539 - (47%)
Similarity:	338/539 - (62%)	Gaps:	65/539 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 QDGDASGAVAPAVTPQLPIYIAQPSAKKPENKIKCHCDTCKES--NNICETDGFCFTSVEKNSDG 157
            :||:::.                |:|:....:.||| ..|.|.  ||||.|||:|||.:|::..|
  Rat    16 EDGESTA----------------PTARPKVLRCKCH-HHCPEDSVNNICSTDGYCFTMIEEDDSG 63

  Fly   158 SIIFSYRCLHKSQIFPPGRSIWCNDGLHGGPTARPVGRNGAHACCKDRDFCNRFLWPKTKDQRSD 222
            :.:.:..||...     |....|.|      |..|..|.... ||.:|:.||:.|.| |.....|
  Rat    64 TPVVTSGCLGLE-----GSDFQCRD------TPIPHQRRSIE-CCTERNECNKDLHP-TLPPLKD 115

  Fly   223 RVEEGRQISVQDYVP----HR--LTSWEFVAIILGATLFICFTGTSTWYYCQRRKRMASGRTFA- 280
            |          |:|.    |:  |.|....:::|...:..|:.         |.||..:...::
  Rat   116 R----------DFVDGPIHHKALLISVTVCSLLLVLIILFCYF---------RYKRQEARPRYSI 161

  Fly   281 --KEDSAYDPILNGNTTIHDIIEMT-TSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGR 342
              ::|..|.|   ...::.|:||.: :||||| ||||||||:||:|:|:...|||||:||||.|:
  Rat   162 GLEQDETYIP---PGESLRDLIEQSQSSGSGS-GLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGK 222

  Fly   343 WRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSL 407
            ||||.||||:|.:.||.|||||.||||||::||||||||||||.|..|:||||:|:|||||||||
  Rat   223 WRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSL 287

  Fly   408 FDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLG 472
            :|||.:..:|..:||.::.|..:||.|||.:|..|:||||||||||||||||||.|.:|.|.|||
  Rat   288 YDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLG 352

  Fly   473 LAVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMG 537
            |||:.:...:.||||...||||||||.|||||||:|..||.||..||:|:||||||||||||..|
  Rat   353 LAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRTHFQSYIMADMYSFGLILWEIARRCVSG 417

  Fly   538 MIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARL 602
            .|.:||||||:|:|..|||.|:|:::||::|.||:.||||.:.:.|..|.|:|.|||..||.:||
  Rat   418 GIVEEYQLPYHDLVPSDPSYEDMREIVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRL 482

  Fly   603 TALRIKKTLASISVEDKVK 621
            ||||:|||||.:|....:|
  Rat   483 TALRVKKTLAKMSESQDIK 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	31/88 (35%)
		GS	294..324	CDD:197743	18/30 (60%)
		Pkinase_Tyr	324..611	CDD:285015	182/286 (64%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	184/286 (64%)
Bmpr1b	XP_006233462.1	Activin_recp	34..106	CDD:395845	29/84 (35%)
Bmpr1b	XP_006233462.1	STKc_BMPR1b	198..502	CDD:271121	191/304 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820