DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and bmpr1ba

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_571532.1	Gene:	bmpr1ba / 30742	ZFINID:	ZDB-GENE-991208-8	Length:	530	Species:	Danio rerio

Alignment Length:	553	Identity:	264/553 - (47%)
Similarity:	343/553 - (62%)	Gaps:	59/553 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 DNNNASAV-SMLLPQDGDA-----SGAVAPAVTPQLPIYIAQPSAKKPENKIKCHC-DTCKE--S 137
            :.|.|:.: ||||...|..     :|:.|||:               |:..:.|:| ..|.|  :
Zfish    23 EENLANVLDSMLLRNSGKVEERRETGSDAPAL---------------PQRFLWCYCYHHCPEDST 72

  Fly   138 NNICETDGFCFTSVEKNSDGSIIFSYRCLHKSQIFPPGRSIWCNDGLHGGPTARPVGRNGAHACC 202
            ||.|.|||:|||.||:....:::.| .||..     .|....|.|      |.....|. |..||
Zfish    73 NNTCRTDGYCFTMVEEEGGAAVVTS-GCLGL-----VGSEFQCRD------TGNSKQRR-ALECC 124

  Fly   203 KDRDFCNRFLWPKTKDQRSDRVEEG--RQISVQDYVPHRLTSWEFVAIILGATLFICFTGTSTWY 265
            .|:|:|||.|.|.....|:.....|  ..|::       |.|....:.||...:..|       |
Zfish   125 TDQDYCNRDLHPTLPPLRTPSYVVGDIHHIAL-------LISVSVCSFILTFIIIFC-------Y 175

  Fly   266 YCQRRKRMASGRTFA-KEDSAYDPILNGNTTIHDIIEMT-TSGSGSAGLPLLVQRSIARQVQLCH 328
            :..:|..:|...:.. ..|.::.|   ...::.|:||.: :||||| ||||||||:||:|:|:..
Zfish   176 FRYKRHELAPRYSLGLHPDESFIP---AGESLRDLIEQSQSSGSGS-GLPLLVQRTIAKQIQMVT 236

  Fly   329 VIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWT 393
            .|||||:||||.||||||.||||:|.:.||.|||||.||||||::||:|||||||||.|..|:||
Zfish   237 QIGKGRYGEVWMGRWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGTGSWT 301

  Fly   394 QLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNI 458
            ||:|:|||||||||:|||....:|:..||.::.|..:||.|||.:|.||:|||||||||||||||
Zfish   302 QLYLITDYHENGSLYDYLKCTTLDSRAMLKLAYSSVSGLCHLHTEIFGTQGKPAIAHRDLKSKNI 366

  Fly   459 LVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAF 523
            |||.|.:|.|.||||||:.:...:.||||...||||||:||||||||::|..||.||..||:|:|
Zfish   367 LVKRNGACCIADLGLAVKFISDTNEVDIPLNTRVGTKRFMAPEVLDETLNRNHFQSYIMADMYSF 431

  Fly   524 GLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAK 588
            |||||||:|||..|.|.:||||||:|.|..|||.|:|::||||::.||:.||||.:.:.|..|.|
Zfish   432 GLILWEISRRCVTGGIVEEYQLPYHDHVPNDPSYEDMREVVCIKRIRPSFPNRWSSDECLRQMGK 496

  Fly   589 VMKECWYPNPVARLTALRIKKTLASISVEDKVK 621
            :|.|||..||.:||||||:|||||.:|....:|
Zfish   497 LMTECWAHNPASRLTALRVKKTLAKMSESQDIK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	32/89 (36%)
		GS	294..324	CDD:197743	18/30 (60%)
		Pkinase_Tyr	324..611	CDD:285015	182/286 (64%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	184/286 (64%)
bmpr1ba	NP_571532.1	Activin_recp	61..138	CDD:279413	33/89 (37%)
		STKc_BMPR1b	226..530	CDD:271121	191/304 (63%)
		S_TKc	233..517	CDD:214567	180/283 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920