DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and acvr1l

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_571420.1	Gene:	acvr1l / 30615	ZFINID:	ZDB-GENE-990415-9	Length:	506	Species:	Danio rerio

Alignment Length:	519	Identity:	247/519 - (47%)
Similarity:	318/519 - (61%)	Gaps:	62/519 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 QPSAKKPENKIKCHC--DTCKESNNICETDGFCFTSVEKNSDGSIIFSYRCLHKSQIFPPGRSIW 179
            |.|||  :..|.|.|  ..|.|..  |..|. |:|||..::|.: .|...||    |.|..:.:.
Zfish    18 QTSAK--DVSIDCMCVGSDCNEQQ--CTGDQ-CYTSVIISNDVT-TFKRGCL----IGPASKRMT 72

  Fly   180 CNDGLHGGPTARPVGRNGAHA--CCKDRDFCN---------RFLW--PKTKDQRSDRVEEGRQIS 231
            |:      .||     :.:|.  || .:..||         |.|.  |:.|.....|||
Zfish    73 CS------ATA-----SASHVVECC-SQHMCNANVSKETLLRLLLTSPEEKKTVHYRVE------ 119

  Fly   232 VQDYVPHRLTSWEFVAIILGATLFICFTGTSTWYYCQR--RKRMASGRTFAKEDSAYDPILN--- 291
                        ..|..:||..:.:..........|:|  ..|:.....|..|..|.|.::.
Zfish   120 ------------MLVLFVLGPFVVLGLLSFLALLVCRRLHHGRLERLHEFDTEQGAIDGLIASNV 172

  Fly   292 GNTTIHDIIEMT-TSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSS 355
            |::|:.|:::.: |||||| |||.||||::|||:.|...:||||:||||||:|:|||||||||||
Zfish   173 GDSTLADLMDHSCTSGSGS-GLPFLVQRTVARQISLVECVGKGRYGEVWRGQWQGENVAVKIFSS 236

  Fly   356 REECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNT 420
            |:|.|||||.|||.||:|||||||||:|:|.....:.|||||:|.|||||||:|||....|:...
Zfish   237 RDEKSWFRETEIYNTVLLRHENILGFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVEMAD 301

  Fly   421 MLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVD 485
            .|:|:.|||:||.|||.:|.||.||||||||||||||||||.:|.|.|.||||||.|.:.::.:|
Zfish   302 GLHMAASIASGLVHLHTEIFGTEGKPAIAHRDLKSKNILVKKDLQCCIADLGLAVTHTQSDNQLD 366

  Fly   486 IPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDV 550
            :.:..:||||||||||||||::....||:|||.|::||||:|||||||.....|.:||:.|:||:
Zfish   367 VGNNPKVGTKRYMAPEVLDETIQTDCFDAYKRVDIWAFGLVLWEIARRTISNGIVEEYKPPFYDL 431

  Fly   551 VQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASI 614
            |..|||.::|:||||:|:.||.|||||.:...|..:.|:||||||.||.||||||||||||..|
Zfish   432 VPNDPSFDDMRKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSARLTALRIKKTLDKI 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	27/101 (27%)
		GS	294..324	CDD:197743	17/30 (57%)
		Pkinase_Tyr	324..611	CDD:285015	179/286 (63%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	181/287 (63%)
acvr1l	NP_571420.1	Activin_recp	28..94	CDD:307282	24/85 (28%)
		TGF_beta_GS	176..203	CDD:312125	15/27 (56%)
		STKc_ACVR1_ALK1	199..496	CDD:271044	186/297 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577716
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850