DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and Acvr1b

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_954700.1	Gene:	Acvr1b / 29381	RGDID:	735207	Length:	505	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	283/542 - (52%)
Similarity:	355/542 - (65%)	Gaps:	58/542 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 ASGAVAPAVTPQLPIYIAQPSAKKPE--NKIKCHCDTCKESNNICETDGFCFTSVEKNSDGSIIF 161
            |..|.|.:..|.:.:.:|......|.  ..:.|.|.:|.::|..|||||.|..|: .|.||....
  Rat     2 AESAGASSFFPLVVLLLAGSGGSGPRGIQALLCACTSCLQTNYTCETDGACMVSI-FNLDGMEHH 65

  Fly   162 SYRCLHKSQIFPPGRSIWC--NDGLHGGPTARPVGRNGAHACCKDRDFCNRFLWPKTKDQR--SD 222
            ...|:.|.::.|.|:..:|  ::.|          || .|.|.  .||||:.      |.|  |.
  Rat    66 VRTCIPKVELVPAGKPFYCLSSEDL----------RN-THCCY--IDFCNKI------DLRVPSG 111

  Fly   223 RVEEGRQISVQDYVPHRLTSW---EFVAIILGAT---------LFICFTGTSTWYYCQRRKRMAS 275
            .::|          |...:.|   |.|.||.|..         :|:........|:.::|..|
  Rat   112 HLKE----------PEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDM-- 164

  Fly   276 GRTFAKEDSAYDPILNGNTTIHDII-EMTTSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVW 339
                  ||.:.:..|:.:.|:.|:: :::|||||| ||||.|||::||.:.|..:||||||||||
  Rat   165 ------EDPSCEMCLSKDKTLQDLVYDLSTSGSGS-GLPLFVQRTVARTIVLQEIIGKGRFGEVW 222

  Fly   340 RGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHEN 404
            ||||||.:|||||||||||.|||||||||||||||||||||||||||||||||||||||:||||:
  Rat   223 RGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEH 287

  Fly   405 GSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIG 469
            |||||||..:.|....|:.::||.|:|||||||:||||:|||.||||||||||||||.|..|||.
  Rat   288 GSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIA 352

  Fly   470 DLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRC 534
            ||||||||....|::||....|||||||||||||||::|.:||||:|.||:||.||:.|||||||
  Rat   353 DLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRC 417

  Fly   535 NMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPV 599
            |.|.:::||||||||:|..|||||||:||||.:|.|||:||.|.:.:.|..|.|:|:||||.|..
  Rat   418 NSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGA 482

  Fly   600 ARLTALRIKKTLASISVEDKVK 621
            ||||||||||||:.:||::.||
  Rat   483 ARLTALRIKKTLSQLSVQEDVK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	28/88 (32%)
		GS	294..324	CDD:197743	17/30 (57%)
		Pkinase_Tyr	324..611	CDD:285015	208/286 (73%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	209/286 (73%)
Acvr1b	NP_954700.1	Activin_recp	38..104	CDD:395845	26/79 (33%)
		GS	177..207	CDD:197743	17/30 (57%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..498	CDD:271045	209/286 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338293
Domainoid	1	1.000	447	1.000	Domainoid score	I502
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	549	1.000	Inparanoid score	I1100
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm45122
orthoMCL	1	0.900	-	-		OOG6_103647
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760