DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and Acvr1c

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001104500.1	Gene:	Acvr1c / 269275	MGIID:	2661081	Length:	493	Species:	Mus musculus

Alignment Length:	498	Identity:	259/498 - (52%)
Similarity:	339/498 - (68%)	Gaps:	34/498 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 IKCHCDTCKESNNICETDGFCFTSVE-KNSDGSIIFSYRCLHKSQIFPPGRSIWCNDGLHGGPTA 190
            :||.|..|..||..|:|:|.|:.||. .|....:|.|  |:...::   ...::|:...:...|
Mouse    26 LKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKS--CVSLPEL---NAQVFCHSSNNVTKT- 84

  Fly   191 RPVGRNGAHACCKDRDFCNRF-LWPKTKDQRSDRVEEGRQISVQDYVPHRLTSWEFVAIILGATL 254
                     .|| ..||||.. |...|....:.|:.. .:::|...||..|.|   :|.:|  |:
Mouse    85 ---------ECC-FTDFCNNITLHLPTASPNAPRLGP-TELTVVITVPVCLLS---IAAML--TI 133

  Fly   255 FICFTGTSTWYYCQRRKRMASGRTFAKEDSAYDPILNGNTTIHDII-EMTTSGSGSAGLPLLVQR 318
            :.|.....|:...:|..        .:|..|...::|...|:.|:| :.|.||||| ||||||||
Mouse   134 WACQDRQCTYRKTKRHN--------VEEALAEYSLVNAGKTLKDLIYDATASGSGS-GLPLLVQR 189

  Fly   319 SIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIA 383
            :|||.:.|..::|||||||||.|||.||:|||||||||:|.||||||||||||||||||||||||
Mouse   190 TIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA 254

  Fly   384 ADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAI 448
            |||||||||||||||::|||.|||:|||..:.|....|:.::||||:|||||||:||||:|||||
Mouse   255 ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVGTQGKPAI 319

  Fly   449 AHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFD 513
            ||||:||||||||...:|||.||||||:|....:::|||...:||||||||||:||::||...|:
Mouse   320 AHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLDDTMNLSIFE 384

  Fly   514 SYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWH 578
            |:||||:|:.||:.|||||||::|.:.:||||||||:|..|||||||:||||.:|.|||:||:|.
Mouse   385 SFKRADIYSVGLVYWEIARRCSVGGVVEEYQLPYYDMVPSDPSIEEMRKVVCDQKLRPNLPNQWQ 449

  Fly   579 ASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVEDKVK 621
            :.:.|..|.::|:||||.|..|||||||:|||::.:.|::..|
Mouse   450 SCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKEDCK 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	25/88 (28%)
		GS	294..324	CDD:197743	20/30 (67%)
		Pkinase_Tyr	324..611	CDD:285015	195/286 (68%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	195/286 (68%)
Acvr1c	NP_001104500.1	Activin_recp	27..100	CDD:279413	25/88 (28%)
		TGF_beta_GS	166..193	CDD:285687	18/27 (67%)
		Pkinase_Tyr	195..474	CDD:285015	188/278 (68%)
		STKc_TGFbR1_ACVR1b_ACVR1c	199..486	CDD:271045	195/286 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834703
Domainoid	1	1.000	447	1.000	Domainoid score	I526
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	549	1.000	Inparanoid score	I1135
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm43059
orthoMCL	1	0.900	-	-		OOG6_103647
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5155
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790