DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and Acvrl1

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_071886.1	Gene:	Acvrl1 / 25237	RGDID:	2029	Length:	504	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	240/502 - (47%)
Similarity:	309/502 - (61%)	Gaps:	53/502 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 IKCHCDT--CKESNNICETDGFCFTSVEKNSDGSIIFSYR-CLHKSQIFPPGRSIWCNDGLHGGP 188
            :.|.|:.  ||..  ||:  |...|.|.....|.....|| |...:|....||           |
  Rat    33 VNCTCENPHCKRP--ICQ--GAWCTVVLVREQGRHPQVYRGCGSLNQELCLGR-----------P 82

  Fly   189 TARPVGRNGAHACCKDRDFCNR--FLWPKTKDQRSDRVEEGRQISVQDYVPHRLTSWEFVAIILG 251
            |     ....|.||. |.|||.  .|..:.....|:..|      |..::|          :|||
  Rat    83 T-----EFVNHHCCY-RSFCNHNVSLMLEATQTPSEEPE------VDAHLP----------LILG 125

  Fly   252 ---ATLFICFTGTSTWYYCQRRKRMASGRTFAKEDSAYDPIL----NGNTTIHD-IIEMTTSGSG 308
               |.|.:...||...:..:||:....|......:|:.  ||    .|::.:.| ::...|:|||
  Rat   126 PVLALLVLVALGTLGLWRVRRRQEKQRGLHSDLGESSL--ILKASEQGDSMLGDFLVSDCTTGSG 188

  Fly   309 SAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVML 373
            | |||.||||::||||.|...:||||:||||||.|.||:|||||||||:|.|||||.|||.||:|
  Rat   189 S-GLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLL 252

  Fly   374 RHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMD 438
            ||:|||||||:|.....:.|||||:|.|||:|||:|:|....::....|.:::|.|.||||||::
  Rat   253 RHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVE 317

  Fly   439 IVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPEVL 503
            |.||:||||||||||||:|:||||||.|.|.||||||.|.:.:|.:||.:..|||||||||||||
  Rat   318 IFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVL 382

  Fly   504 DESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEK 568
            ||.:....|:|||..|::||||:|||||||..:..|.::|:.|:||:|..|||.|:||||||:::
  Rat   383 DEQIRTDCFESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQ 447

  Fly   569 CRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASIS 615
            ..|.||||..|..||..:|::|:|||||||.||||||||||||..:|
  Rat   448 QTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLS 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	26/91 (29%)
		GS	294..324	CDD:197743	15/30 (50%)
		Pkinase_Tyr	324..611	CDD:285015	177/286 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	177/286 (62%)
Acvrl1	NP_071886.1	Mediates specificity for BMP ligand. /evidence=ECO:0000250	74..77		1/2 (50%)
		TGF_beta_GS	174..201	CDD:400699	13/27 (48%)
		STKc_ACVR1_ALK1	197..494	CDD:271044	183/296 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338282
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750