DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and Acvr1c

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_620790.2	Gene:	Acvr1c / 245921	RGDID:	621789	Length:	493	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	255/505 - (50%)
Similarity:	333/505 - (65%)	Gaps:	48/505 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 IKCHCDTCKESNNICETDGFCFTSVE-KNSDGSIIFSYRCLHKSQIFPPGRSIWCNDGLHGGPTA 190
            :||.|..|..||..|:|:|.|:.||. .|....:|.|  |:...::   ...::|:...:...|
  Rat    26 LKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKS--CVSLPEL---NAQVFCHSSNNVTKT- 84

  Fly   191 RPVGRNGAHACCKDRDFCNRFLWPKTKDQRSDRVEEGRQISVQDYVP------HRLTSWEFVAII 249
                     .|| ..||||                     ::..::|      .||...|...:|
  Rat    85 ---------ECC-FTDFCN---------------------NITLHLPTASPDAPRLGPTELTVVI 118

  Fly   250 LGATLFICFTGTSTWYYCQRRK--RMASGRTFAKEDSAYDPILNGNTTIHDII-EMTTSGSGSAG 311
            ......:......|.:.||.|:  ...:.|...:|..|...::|...|:.|:| :.|.||||| |
  Rat   119 TVPVCLLSIAAMLTIWACQDRQCTYRKTKRHNVEEPLAEYSLVNAGKTLKDLIYDATASGSGS-G 182

  Fly   312 LPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHE 376
            |||||||:|||.:.|..::|||||||||.|||.||:|||||||||:|.|||||||||||||||||
  Rat   183 LPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHE 247

  Fly   377 NILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVG 441
            ||||||||||||||||||||||::|||.|||:|||..:.|....|:.::||||:|||||||:|||
  Rat   248 NILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVG 312

  Fly   442 TRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDES 506
            |:|||||||||:||||||||...:|||.||||||:|....:::|||...:||||||||||:||::
  Rat   313 TQGKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLDDT 377

  Fly   507 MNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRP 571
            ||...|:|:||||:|:.||:.|||||||::|.:.:||||||||:|..|||||||:||||.:|.||
  Rat   378 MNVNIFESFKRADIYSVGLVYWEIARRCSVGGLVEEYQLPYYDMVPSDPSIEEMRKVVCDQKLRP 442

  Fly   572 NIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVEDKVK 621
            |:||:|.:.:.|..|.::|:||||.|..|||||||:|||::.:.|::..|
  Rat   443 NLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKEDCK 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	24/87 (28%)
		GS	294..324	CDD:197743	20/30 (67%)
		Pkinase_Tyr	324..611	CDD:285015	195/286 (68%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	195/286 (68%)
Acvr1c	NP_620790.2	Activin_recp	33..95	CDD:395845	21/98 (21%)
		TGF_beta_GS	166..193	CDD:400699	18/27 (67%)
		STKc_TGFbR1_ACVR1b_ACVR1c	199..486	CDD:271045	195/286 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338285
Domainoid	1	1.000	447	1.000	Domainoid score	I502
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	549	1.000	Inparanoid score	I1100
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm45122
orthoMCL	1	0.900	-	-		OOG6_103647
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800