DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and Bmpr1b

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001264145.1	Gene:	Bmpr1b / 12167	MGIID:	107191	Length:	502	Species:	Mus musculus

Alignment Length:	540	Identity:	258/540 - (47%)
Similarity:	338/540 - (62%)	Gaps:	67/540 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 QDGDASGAVAPAVTPQLPIYIAQPSAKKPENKIKCHC-DTCKES--NNICETDGFCFTSVEKNSD 156
            :||:::   ||...|::               ::|.| ..|.|.  ||||.|||:|||.:|::..
Mouse    16 EDGEST---APTPRPKI---------------LRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDS 62

  Fly   157 GSIIFSYRCLHKSQIFPPGRSIWCNDGLHGGPTARPVGRNGAHACCKDRDFCNRFLWPKTKDQRS 221
            |..:.:..||...     |....|.|      |..|..|.... ||.:|:.||:.|.| |.....
Mouse    63 GMPVVTSGCLGLE-----GSDFQCRD------TPIPHQRRSIE-CCTERNECNKDLHP-TLPPLK 114

  Fly   222 DRVEEGRQISVQDYVP----HR--LTSWEFVAIILGATLFICFTGTSTWYYCQRRKRMASGRTFA 280
            ||          |:|.    |:  |.|....:::|...:..|:.         |.||..:...::
Mouse   115 DR----------DFVDGPIHHKALLISVTVCSLLLVLIILFCYF---------RYKRQEARPRYS 160

  Fly   281 ---KEDSAYDPILNGNTTIHDIIEMT-TSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRG 341
               ::|..|.|   ...::.|:||.: :||||| ||||||||:||:|:|:...|||||:||||.|
Mouse   161 IGLEQDETYIP---PGESLRDLIEQSQSSGSGS-GLPLLVQRTIAKQIQMVKQIGKGRYGEVWMG 221

  Fly   342 RWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGS 406
            :||||.||||:|.:.||.|||||.||||||::||||||||||||.|..|:||||:|:||||||||
Mouse   222 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGS 286

  Fly   407 LFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDL 471
            |:|||.:..:|..:||.::.|..:||.|||.:|..|:||||||||||||||||||.|.:|.|.||
Mouse   287 LYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADL 351

  Fly   472 GLAVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNM 536
            ||||:.:...:.||||...||||||||.|||||||:|..||.||..||:|:||||||||||||..
Mouse   352 GLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEIARRCVS 416

  Fly   537 GMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVAR 601
            |.|.:||||||:|:|..|||.|:|:::||::|.||:.||||.:.:.|..|.|:|.|||..||.:|
Mouse   417 GGIVEEYQLPYHDLVPSDPSYEDMREIVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAQNPASR 481

  Fly   602 LTALRIKKTLASISVEDKVK 621
            |||||:|||||.:|....:|
Mouse   482 LTALRVKKTLAKMSESQDIK 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	30/89 (34%)
		GS	294..324	CDD:197743	18/30 (60%)
		Pkinase_Tyr	324..611	CDD:285015	182/286 (64%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	184/286 (64%)
Bmpr1b	NP_001264145.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		3/10 (30%)
		Activin_recp	34..106	CDD:395845	28/83 (34%)
		STKc_BMPR1b	198..502	CDD:271121	191/304 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820