DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment babo and Acvrl1

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001264184.1	Gene:	Acvrl1 / 11482	MGIID:	1338946	Length:	517	Species:	Mus musculus

Alignment Length:	529	Identity:	235/529 - (44%)
Similarity:	303/529 - (57%)	Gaps:	97/529 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 KPENKIKCHCDT--CKESNNICETDGFCFTSVEKNSDGSIIFSYRCLHKSQIFPPGRSIWC---- 180
            ||...:.|.|::  ||..        ||        .||                    ||
Mouse    41 KPSKLVNCTCESPHCKRP--------FC--------QGS--------------------WCTVVL 69

  Fly   181 --NDGLH----------------GGPTARPVGRNGAHACCKDRDFCNR--FLWPKTKDQRSDRVE 225
              ..|.|                |.||     ....|.||. |.|||.  .|..:.....|:..|
Mouse    70 VREQGRHPQVYRGCGSLNQELCLGRPT-----EFLNHHCCY-RSFCNHNVSLMLEATQTPSEEPE 128

  Fly   226 EGRQISVQDYVPHRLTSWEFVAIILGATL----FICFTGTSTWYYCQRRKRMASGRTFAKEDSAY 286
                  |..::|          :|||..|    .:.......|...:|:::.....:...|.|.
Mouse   129 ------VDAHLP----------LILGPVLALPVLVALGALGLWRVRRRQEKQRDLHSDLGESSL- 176

  Fly   287 DPIL----NGNTTIHDIIEM-TTSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGE 346
              ||    ..::.:.|.::. .|:|||| |||.||||::||||.|...:||||:||||||.|.||
Mouse   177 --ILKASEQADSMLGDFLDSDCTTGSGS-GLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGE 238

  Fly   347 NVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYL 411
            :|||||||||:|.|||||.|||.||:|||:|||||||:|.....:.|||||:|.|||:|||:|:|
Mouse   239 SVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL 303

  Fly   412 TTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVR 476
            ....::....|.:::|.|.||||||::|.||:||||||||||||:|:||||||.|.|.||||||.
Mouse   304 QRQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVM 368

  Fly   477 HVEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYD 541
            |.:.:|.:||.:..|||||||||||||||.:....|:|||..|::||||:|||||||..:..|.:
Mouse   369 HSQSSDYLDIGNNPRVGTKRYMAPEVLDEHIRTDCFESYKWTDIWAFGLVLWEIARRTIINGIVE 433

  Fly   542 EYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALR 606
            :|:.|:||:|..|||.|:||||||:::..|.||||..|..||..:|::|:|||||||.|||||||
Mouse   434 DYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALR 498

  Fly   607 IKKTLASIS 615
            |||||..:|
Mouse   499 IKKTLQKLS 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	23/112 (21%)
		GS	294..324	CDD:197743	15/30 (50%)
		Pkinase_Tyr	324..611	CDD:285015	177/286 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	177/286 (62%)
Acvrl1	NP_001264184.1	LU	48..112	CDD:299177	22/105 (21%)
		TGF_beta_GS	187..214	CDD:285687	13/27 (48%)
		STKc_ACVR1_ALK1	210..507	CDD:271044	183/296 (62%)
		Pkinase_Tyr	216..503	CDD:285015	177/286 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834700
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750