Protein Alignment babo and Acvr2a

DIOPT Version :10

• Sequence 1: NP_476999.1
• Gene: babo / 35900
• FlyBaseID: FBgn0011300
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: XP_006497686.1
• Gene: Acvr2a / 11480
• MGIID: 102806
• Length: 521
• Species: Mus musculus
• Alignment Length: 435
• Identity: 155/435 - (35%)
• Similarity: 238/435 - (54%)
• Gaps: 49/435 - (11%)

  Fly   201 CCKDRDFCN-RF-LWPKTKDQRSDRVEEGRQISVQDYVP-HRLTSWEFVAIILGATLFICFTGTS 262
            ||.:.:.|| :| .:|:.:      |.:.....|....| :.:..:..|.::|.|.:.||    :
Mouse   103 CCCEGNMCNEKFSYFPEME------VTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVIC----A 157

  Fly   263 TWYYCQRRKRMASGRTFAKEDSAYDPILNGNTTIHDIIEMTTSGSGSAGLPLLVQRSIARQVQLC 327
            .|.|  |..:|           ||.|:|  ..|.|....|..........|||.    .:.:||.
Mouse   158 FWVY--RHHKM-----------AYPPVL--VPTQHAFHIMIEDPGPPPPSPLLG----LKPLQLL 203

  Fly   328 HVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTW 392
            .|..:||||.||:.:...|.||||||..:::.||..|.|:|....::|||||.||.|:.:.....
Mouse   204 EVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVD 268

  Fly   393 TQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRG--KPAIAHRDLKS 455
            ..|||:|.:||.|||.|:|..:.|..|.:.:::.::|.|||:||.||.|.:.  ||||:|||:||
Mouse   269 VDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKS 333

  Fly   456 KNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTH-RVGTKRYMAPEVLDESMNDQHFDSYKRAD 519
            ||:|:|:||:..|.|.|||::......:.|   || :|||:||||||||:.::|.|. |::.|.|
Mouse   334 KNVLLKNNLTACIADFGLALKFEAGKSAGD---THGQVGTRRYMAPEVLEGAINFQR-DAFLRID 394

  Fly   520 VYAFGLILWEIARRCNM--GMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDV 582
            :||.||:|||:|.||..  |.: |||.||:.:.:...||:|:|::||..:|.||.:.:.|.....
Mouse   395 MYAMGLVLWELASRCTAADGPV-DEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAG 458

  Fly   583 LHNMAKVMKECWYPNPVARLTA-------LRIKKTLASISVEDKV 620
            :..:.:.::|||..:..|||:|       .::::....|:.||.|
Mouse   459 MAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIV 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	TFP_LU_ECD_Babo	127..210	CDD:467127	4/9 (44%)
		GS	294..324	CDD:197743	6/29 (21%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	121/298 (41%)
Acvr2a	XP_006497686.1	TFP_LU_ECD_ACVR2A	25..119	CDD:467151	5/15 (33%)
		STKc_ACVR2a	204..493	CDD:271043	121/293 (41%)