DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and acvrl1

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_002935162.2	Gene:	acvrl1 / 100493282	XenbaseID:	XB-GENE-484224	Length:	505	Species:	Xenopus tropicalis

Alignment Length:	510	Identity:	229/510 - (44%)
Similarity:	311/510 - (60%)	Gaps:	49/510 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 ENKIK------CHCDTCKESNNICETDGFCFTSVEKNSDGSIIFSYRCLHKSQIFPPGRSIWCND 182
            |:|.|      |:|:....|...| ....|:.:....|:...|...:....:.|.....|:..|.
Frog    30 EDKTKGSKYWTCYCNDASCSGETC-VGRVCYVTESYASESEGISRAKGCFNNSIKEHCSSLMSNL 93

  Fly   183 GLHGGPTARPVGRNGAHACCKDRDFCNRFLWPKTKDQRSDRVEEGRQISVQDYVPHRLTSWEFVA 247
            ..|               || :.||||:           |:|   ..:::...:...|......:
Frog    94 KEH---------------CC-EWDFCNK-----------DKV---LNVTINPSLVTLLLVTVLPS 128

  Fly   248 IILGATLFICFTGTSTWYY---CQRRKR-MASGRTFAKEDSAYDPILNGNTTIHDII-EMTTSGS 307
            :|....||:..    .|.|   ..||.| :|....|...|.....:: |::|:.:.: |..|:||
Frog   129 VIFIVILFLVI----AWIYKAKLHRRNRLLAMPSDFDDADMLKASVV-GDSTLGEFLDEYCTTGS 188

  Fly   308 GSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVM 372
            || |||.||||::|||:.|...:||||:||||||.|:||||||||||||:|.|||||.|||.||:
Frog   189 GS-GLPFLVQRTVARQITLVECVGKGRYGEVWRGTWQGENVAVKIFSSRDEQSWFRETEIYNTVL 252

  Fly   373 LRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHM 437
            |||||||||||:|.....:.|||||:|.||::|||:|||....||:...|.::|||..||.|||:
Frog   253 LRHENILGFIASDMTSRNSSTQLWLITHYHDDGSLYDYLQRTSVDSEGCLKLALSIICGLVHLHV 317

  Fly   438 DIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPEV 502
            :|.||:||.|||||||||:|||||:|..|.|.||||||.|.:..|.:||.:..||||||||||||
Frog   318 EIFGTQGKAAIAHRDLKSRNILVKANKQCCIADLGLAVMHSQNGDYLDIGNNPRVGTKRYMAPEV 382

  Fly   503 LDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIE 567
            |||::....|:|||:.|::|:||:||||.||..:..:.::|:.|::|||..|||.|:|:|||||:
Frog   383 LDETIRTDSFESYKQTDLWAYGLVLWEICRRTVVNGMVEDYRPPFFDVVPHDPSFEDMRKVVCID 447

  Fly   568 KCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASI-SVEDKVK 621
            :.||||.|.|.:.::|..|.|:|:|||:.:|.||||||||||||..: |..|::|
Frog   448 QQRPNISNTWSSDNILSAMTKIMRECWFSSPSARLTALRIKKTLNKLRSSLDQIK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	18/92 (20%)
		GS	294..324	CDD:197743	16/30 (53%)
		Pkinase_Tyr	324..611	CDD:285015	172/286 (60%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	173/287 (60%)
acvrl1	XP_002935162.2	TGF_beta_GS	175..202	CDD:369918	14/27 (52%)
acvrl1	XP_002935162.2	STKc_ACVR1_ALK1	198..494	CDD:271044	178/295 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920