DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babo and acvr1c

DIOPT Version :9

Sequence 1:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_002933316.2	Gene:	acvr1c / 100487548	XenbaseID:	XB-GENE-487108	Length:	537	Species:	Xenopus tropicalis

Alignment Length:	505	Identity:	260/505 - (51%)
Similarity:	338/505 - (66%)	Gaps:	48/505 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 IKCHCDTCKESNNICETDGFCFTSVEKNSDGSIIFSYRCL----HKSQIFPPGRSIWCNDGLHGG 187
            :||.|..|:.:|..|:|:|.|:|||........:.. .|:    .|:|:|       |:
Frog    70 LKCVCLLCENTNYTCQTEGACWTSVMLTHGKEEVLK-SCISLPEFKAQVF-------CH------ 120

  Fly   188 PTARPVGRNGAHACCKDRDFCNRFLWPKTKDQRSDRVEEGRQISVQDYVPHRLTSWEFVAIILGA 252
             ::..:.|.   .||.. ||||..      ..|...|..|  :|...:|       |...|:
Frog   121 -SSNNITRT---ECCLS-DFCNNI------TLRLPAVTPG--VSHMGHV-------ELTVIV--- 162

  Fly   253 TLFICFTGT---STWYYCQRR--KRMASGRTFAKEDSAYDPILNGNTTIHDII-EMTTSGSGSAG 311
            |:.||....   .|.|.||.|  .:..:.|...:|.....|:.....::.|:| :|||||||| |
Frog   163 TVSICLLSVVIMVTAYVCQERYCAKNKARRQCVEEPLTECPLDIAGKSLKDLIYDMTTSGSGS-G 226

  Fly   312 LPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHE 376
            |||||||:|||.|.:..::|||||||||||:|.||:|||||||||:|.|||||||||||||||||
Frog   227 LPLLVQRTIARTVVIQELVGKGRFGEVWRGKWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHE 291

  Fly   377 NILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVG 441
            |||||||||||||||||||||::::||.|||||||..:.|....|:.::||:.:|||||||:|||
Frog   292 NILGFIAADNKDNGTWTQLWLISEFHEQGSLFDYLNCNTVTIGGMMKLALSVVSGLAHLHMEIVG 356

  Fly   442 TRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDES 506
            |:||||||||||||||||||.|.:|.|.||||||:|....:::|||...|||||||||||:||:|
Frog   357 TQGKPAIAHRDLKSKNILVKKNETCCIADLGLAVKHDSITNTIDIPQNPRVGTKRYMAPELLDDS 421

  Fly   507 MNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRP 571
            :|..||||:|.:|:|:.||:.|||||||::|.:.|||||||||:|..|||:|:::||||.:|.||
Frog   422 INTYHFDSFKCSDIYSLGLVYWEIARRCSVGGVVDEYQLPYYDMVPSDPSLEDVRKVVCEQKLRP 486

  Fly   572 NIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVEDKVK 621
            :|||:|.:.:.|..|.::|:||||.|..|||||||||||::.:.||:..|
Frog   487 SIPNQWQSFEALRIMGRIMRECWYANGKARLTALRIKKTISQLCVEEDYK 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	24/90 (27%)
		GS	294..324	CDD:197743	21/30 (70%)
		Pkinase_Tyr	324..611	CDD:285015	193/286 (67%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	193/286 (67%)
acvr1c	XP_002933316.2	Activin_recp	70..139	CDD:366445	24/87 (28%)
		TGF_beta_GS	210..237	CDD:369918	19/27 (70%)
		STKc_TGFbR1_ACVR1b_ACVR1c	243..530	CDD:271045	193/286 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	450	1.000	Domainoid score	I511
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	537	1.000	Inparanoid score	I1169
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm48184
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070