DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8230 and dym

DIOPT Version :9

Sequence 1:	NP_610431.1	Gene:	CG8230 / 35897	FlyBaseID:	FBgn0027607	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	XP_031757262.1	Gene:	dym / 734107	XenbaseID:	XB-GENE-5729291	Length:	724	Species:	Xenopus tropicalis

Alignment Length:	766	Identity:	318/766 - (41%)
Similarity:	438/766 - (57%)	Gaps:	114/766 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGINVSRTADLGSNQWLQRFVGRQHIAHDDEAFWNGLLNYNIVLPENSQDQLNLDSRLEALCQSF 65
            ||.|.|...:|..|::|::..|...|: ::|.|||.||:::...|.||.|...|:....::|:|.
Frog     1 MGANSSTIKELSENEFLKKLSGTDSIS-ENEPFWNQLLSFSFSTPTNSADSKLLEEGTLSICKSL 64

  Fly    66 IGNNLKTGNFGSLVTVFLEKTSELLSLSDQESNMHVWQTFNALFIIRSLVKYINETGSEFQLLQH 130
            |.||.:|||.|:|:.|||.:|.||...::.::.:.:||..||||||..|:|......||.:||.|
Frog    65 IENNPRTGNLGALIRVFLSRTKELKISAECQNQLFIWQAHNALFIICRLIKVFTSQISEEELLLH 129

  Fly   131 FEAMPNAELLQAALEQQQQTPAESATIAMEATEQSAAAAVPVIVDGSKFETFIDALVNLIVVIPV 195
            |                ...||:......: ||             :.||..:..|:.|||.||:
Frog   130 F----------------TYRPADPGNYESD-TE-------------NLFEELLFCLIQLIVEIPL 164

  Fly   196 KEFTYHLHLEAVNMLITLLSVHLFAQQPTDKSIVFRTVFK--C-QHANVLMSALLHFVARIVEVP 257
            .:.||.:.||||..||.|||..||.:....:|.:.|.:.|  | .:.:.|:..||:...|..:.|
Frog   165 LDLTYSILLEAVTALIVLLSYQLFRKDILHESPIHRHLMKGPCLPYTSRLVKTLLYNFIRQEKSP 229

  Fly   258 ----HTMFGSSSAGSFVFGIAESLLS-IFTFRKQPDILKAGQAAGGGELSQRFRTHYPLANQSLL 317
                |........|..::|:|..:.| |:|      :|..|..  |.:.:.:.....||||||||
Frog   230 PPGSHIFPQQQDGGGLLYGLASGVASGIWT------VLTLGGV--GSKPTPQQEQSSPLANQSLL 286

  Fly   318 LILILTNHCTAQD--NAYRTSLF---SCADSKDSPKQGAVSFQIDFSAVYETLCTIVTIDQATLL 377
            |:|:|:|...|.|  |.:|.|:.   :..||..||.....||||:|:::|..||.....||||||
Frog   287 LLLVLSNLTDAPDCPNPFRQSVTFFRNTQDSSVSPTPNPHSFQINFNSLYTALCEQQKSDQATLL 351

  Fly   378 LYLLLHRNERFYRFVMQQQDLEQLVIPILQTLYNAPDSNSHHIYMSLIVLLILSEDEGFNKNVHT 442
            ||.|||:|.....:|:.:.|:|.||:|||:.||:..|.||||:||:||:||||:||:|||:::|.
Frog   352 LYTLLHQNSNVRTYVLARSDMENLVLPILEILYHVEDRNSHHVYMALIILLILTEDDGFNRSIHE 416

  Fly   443 IMLKNITWYTERTISEISLGGILILIVIRTIQYNMLKMRDKYLHTNCLAALANMSGHFRALHPYV 507
            ::||||||||||.::|||||.:|||:|||||||||.:.|||||||||||||||||..||:||.|.
Frog   417 VILKNITWYTERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNCLAALANMSAQFRSLHQYA 481

  Fly   508 AQRLV-------------------------------------------------------SLFET 517
            |||::                                                       |||..
Frog   482 AQRIISYACRHLRRYLYVLDKLYFPHSHCATLQHCFSALSDNGEELLSLTCSHILRSYASSLFSL 546

  Fly   518 LARKHTRLDAQLKEPADSAVFVNVSTTPEDMLQDLSVLEEVLRMVLEILNSCLTNQLVYCPNLVY 582
            |::||.::..|..:....::..:.|..| |..|||:|:|||:||:|||:||||||.|.:.||:||
Frog   547 LSKKHNKVLEQATQSLRGSLGSDESPLP-DYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPNMVY 610

  Fly   583 TLLYKRSVFEGFRSHHAFQDVIQNIDMVVGFFSSRLQRVQEQRG-ELGVNEVLEVISKGASQWSS 646
            .|||||.:||.||||.:|||::||||||:.|||.||    ||.| :|.|..|||||.:||.....
Frog   611 ALLYKRELFEQFRSHPSFQDIMQNIDMVISFFSLRL----EQAGADLSVERVLEVIKQGAVALPK 671

  Fly   647 DRLRKFPDLKFKYVEEDAPEEFFIPYVWTLVCKYGC-VHFSSESIKSVTTD 696
            |||||||:||||||||:.||||||||.|:||...|. ::::.:.|:..|.|
Frog   672 DRLRKFPELKFKYVEEEQPEEFFIPYAWSLVYHSGVGLYWNPQDIQLFTMD 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8230	NP_610431.1	Dymeclin	1..676	CDD:286785	312/743 (42%)
dym	XP_031757262.1	Dymeclin	1..699	CDD:401621	311/741 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	534	1.000	Domainoid score	I280
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69237
Inparanoid	1	1.050	538	1.000	Inparanoid score	I1165
OMA	1	1.010	-	-		QHG48855
OrthoDB	1	1.010	-	-		D152977at33208
OrthoFinder	1	1.000	-	-		FOG0005697
OrthoInspector	1	1.000	-	-		otm47605
Panther	1	1.100	-	-	LDO	PTHR12895
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3721
SonicParanoid	1	1.000	-	-		X4094
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110