Protein Alignment CG8230 and DYM

DIOPT Version :10

• Sequence 1: NP_610431.1
• Gene: CG8230 / 35897
• FlyBaseID: FBgn0027607
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: XP_047293516.1
• Gene: DYM / 54808
• HGNCID: 21317
• Length: 752
• Species: Homo sapiens
• Alignment Length: 726
• Identity: 278/726 - (38%)
• Similarity: 408/726 - (56%)
• Gaps: 119/726 - (16%)

  Fly     1 MGINVSRTADLGSNQWLQRFVGRQHIAHDDEAFWNGLLNYNIVLPENSQDQLNLDSRLEALCQSF 65
            ||.|.||..||..|::|::..|.:.|:.:| .|||.||:::...|.:|.:...|:....::|:|.
Human     1 MGSNSSRIGDLPKNEYLKKLSGTESISEND-PFWNQLLSFSFPAPTSSSELKLLEEATISVCRSL 64

  Fly    66 IGNNLKTGNFGSLVTVFLEKTSELLSLSDQESNMHVWQTFNALFIIRSLVKYINETGSEFQLLQH 130
            :.||.:|||.|:|:.|||.:|.||...::.::::.:|||.||||||..|:|......||.:|..|
Human    65 VENNPRTGNLGALIKVFLSRTKELKLSAECQNHIFIWQTHNALFIICCLLKVFICQMSEEELQLH 129

  Fly   131 FEAMPNAELLQAALEQQQQTPAESATIAMEATEQSAAAAVPVIVDGSKFETFIDALVNLIVVIPV 195
            |             ..::::|...::.:.:..|:                 .:..|:.||..||:
Human   130 F-------------TYEEKSPGNYSSDSEDLLEE-----------------LLCCLMQLITDIPL 164

  Fly   196 KEFTYHLHLEAVNMLITLLSVHLFAQQPTDKSIVFRTVFK--C-QHANVLMSALLHFVARIVEVP 257
            .:.||.:.:||::.::..||..||.::...:||..:.:.:  | .:.:.|:..||:...|..:.|
Human   165 LDITYEISVEAISTMVVFLSCQLFHKEVLRQSISHKYLMRGPCLPYTSKLVKTLLYNFIRQEKPP 229

  Fly   258 ----HTMFGSSSAGSFVF----GIAESLLSIFTFRKQPDILKAGQAAGGGELSQRFRTHYPLANQ 314
                |.....|..|..::    |:|..|.::||...     ...:||...|||.      |||||
Human   230 PPGAHVFPQQSDGGGLLYGLASGVATGLWTVFTLGG-----VGSKAAASPELSS------PLANQ 283

  Fly   315 SLLLILILTNHCTAQD--NAYRTSLFSCADSKDS---PKQGAVSFQIDFSAVYETLCTIVTIDQA 374
            ||||:|:|.|...|.|  |.||.::.|..:::||   |.....:|||:|:::|..||...|.|||
Human   284 SLLLLLVLANLTDASDAPNPYRQAIMSFKNTQDSSPFPSSIPHAFQINFNSLYTALCEQQTSDQA 348

  Fly   375 TLLLYLLLHRNERFYRFVMQQQDLEQLVIPILQTLYNAPDSNSHHIYMSLIVLLILSEDEGFNKN 439
            |||||.|||:|.....:::.:.|:|.||:|||:.||:..:.||||:||:||:||||:||:|||::
Human   349 TLLLYTLLHQNSNIRTYMLARTDMENLVLPILEILYHVEERNSHHVYMALIILLILTEDDGFNRS 413

  Fly   440 VHTIMLKNITWYTERTISEISLGGILILIVIRTIQYNMLKMRDKYLHTNCLAALANMSGHFRALH 504
            :|.::|||||||:||.::|||||.:|||:|||||||||.:.|||||||||||||||||..||:||
Human   414 IHEVILKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNCLAALANMSAQFRSLH 478

  Fly   505 PYVAQRLV-------------------------------------------------------SL 514
            .|.|||::                                                       ||
Human   479 QYAAQRIISYTCRHLRRYVYVLDKLYFPHSHCSTLQHCFSTLSDNGEELLSLTCSHILRSYASSL 543

  Fly   515 FETLARKHTRLDAQLKEPADSAVFVNVSTTPEDMLQDLSVLEEVLRMVLEILNSCLTNQLVYCPN 579
            |..|::||.::..|..:....::..|....| |..|||:|:|||:||:|||:||||||.|.:.||
Human   544 FSLLSKKHNKVLEQATQSLRGSLSSNDVPLP-DYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPN 607

  Fly   580 LVYTLLYKRSVFEGFRSHHAFQDVIQNIDMVVGFFSSRLQRVQEQRG-ELGVNEVLEVISKGASQ 643
            |||.|||||.:||.||:|.:|||::||||:|:.||||||.    |.| ||.|..|||:|.:|...
Human   608 LVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLL----QAGAELSVERVLEIIKQGVVA 668

  Fly   644 WSSDRLRKFPD 654
            ...|||:...|
Human   669 LPKDRLKPLAD 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8230	NP_610431.1	Dymeclin	1..676	CDD:462873	278/726 (38%)
DYM	XP_047293516.1	Dymeclin	1..673	CDD:462873	274/718 (38%)