DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG13748 and Aplp1

DIOPT Version :10

Sequence 1:NP_610430.1 Gene:CG13748 / 35896 FlyBaseID:FBgn0033355 Length:113 Species:Drosophila melanogaster
Sequence 2:NP_031493.2 Gene:Aplp1 / 11803 MGIID:88046 Length:654 Species:Mus musculus


Alignment Length:28 Identity:8/28 - (28%)
Similarity:14/28 - (50%) Gaps:8/28 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 GVCRAL-------IPRWRYDPEQ-KKCV 86
            |:|..|       ..||..||:: ::|:
Mouse    58 GLCGRLTLHRDLRTGRWEPDPQRSRRCL 85

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG13748NP_610430.1 Kunitz-type 57..112 CDD:444694 8/28 (29%)
Aplp1NP_031493.2 A4_EXTRA 46..211 CDD:128326 8/28 (29%)
GFLD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 50..146 8/28 (29%)
CuBD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 154..212
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 214..297
APP_E2 289..471 CDD:463752
Heparin-binding. /evidence=ECO:0000250 314..346
Heparin-binding. /evidence=ECO:0000250 414..445
Collagen-binding. /evidence=ECO:0000250 446..463
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 497..580
JMTM_Notch_APP 568..652 CDD:425406
Basolateral sorting signal. /evidence=ECO:0000250 608..619
Interaction with DAB1 636..652
Interaction with DAB2. /evidence=ECO:0000269|PubMed:11247302 640..654
NPXY motif, contains endocytosis signal 644..647
Blue background indicates that the domain is not in the aligned region.

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